Abstract:Non-toxic doses of tetrakis-mu-3,5-diisopropylsalicylatodicopper(II) [Cu(II)2(3,5-DIPS)4] have been found to have anti-inflammatory, analgesic, anti-ulcer, anti-colitis, anti-convulsant, anti-cancer, anti-mutagenic, anti-carcinogenic, and anti-diabetic activities and, in addition, facilitates recovery from lethal irradiation and ischemia-reperfusion injuries. The goal of this research was to determine the time-dependent tissue distribution and persistence of 67Cu and the 14C labeled salicylate ligand, carboxy-… Show more
“…Moreover, Cu complexes exhibit lipophilic activity that enhances their migration towards the intracellular space of the hepatic tissue where they could be considered as a mediator for the newly synthesized CP and cellular Cu-dependent enzymes. The marked lipophilicity of the Cu salicylate accounted for its very rapid distribution to all tissues, where it undergoes ligand exchange as Cu salicylate is incorporated into Cu-dependent enzymes and proteins and persists in tissues based upon physiological demand for Cu in meeting normal biochemical requirements (31).…”
The Cu complex may serve as a novel chemical restoring agent in fatty degenerated liver cells and for renewal of their structure and functions. However, clinical trials are required for more evaluation of the Cu complex in humans.
“…Moreover, Cu complexes exhibit lipophilic activity that enhances their migration towards the intracellular space of the hepatic tissue where they could be considered as a mediator for the newly synthesized CP and cellular Cu-dependent enzymes. The marked lipophilicity of the Cu salicylate accounted for its very rapid distribution to all tissues, where it undergoes ligand exchange as Cu salicylate is incorporated into Cu-dependent enzymes and proteins and persists in tissues based upon physiological demand for Cu in meeting normal biochemical requirements (31).…”
The Cu complex may serve as a novel chemical restoring agent in fatty degenerated liver cells and for renewal of their structure and functions. However, clinical trials are required for more evaluation of the Cu complex in humans.
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