A novel therapeutic drug (copper nicotinic acid complex) for non‐alcoholic fatty liver

Salama, Ragaa H. M.; Nassar, Ahmed; Nafady, Asmaa; Mohamed, Hesham H. T.

doi:10.1111/j.1478-3231.2007.01460.x

Cited by 30 publications

(31 citation statements)

References 29 publications

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“…This, in turn, results in lower levels of ferroportin in copper deficient rats; coincidentally, NAFLD patients show less ferroportin expression than controls (93). Copper supplementation has been suggested as a therapy for NAFLD based on study in which a diet-induced (high carbohydrate fat-free diet) NAFLD in rats was improved by treatment with a Cu(I)-nicotinate complex (95).…”

Section: Copper and Nafldmentioning

confidence: 99%

The Role of Copper as a Modifier of Lipid Metabolism

Burkhead¹,

Lutsenko²

2013

Lipid Metabolism

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Section: Copper and Nafldmentioning

confidence: 99%

The Role of Copper as a Modifier of Lipid Metabolism

Burkhead¹,

Lutsenko²

2013

Lipid Metabolism

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“…In addition, these cellular improving characters were microscopically obvious by utilization of the copper complex under consideration as a protective agent. This improvement was predicted since this complex has been confirmed previously as a therapeutic agent against induced non-alcoholic fatty liver in experimental animals [20].…”

Section: Discussionmentioning

confidence: 56%

“…Reduction of accumulated levels NO and lipid peroxides in hepatic tissue by BHT and the copper complex cotreatment that was regulated and promoted by elevation of antioxidant cellular chemicals such as GSH and total thiols [39], this could be attributed frankly to the antioxidant effect of BHT [20,40] and the cellular protective antioxidant Cu(I)-nicotinate complex [41]. Since, induction of protective GST has been posited possible chemoprotective mechanism by BHT and other phenolic antioxidant as enzyme promoters has been confirmed before by Hayes et al, (1996) [42].…”

Section: Discussionmentioning

confidence: 99%

“…Generally, antioxidants may impact their anti-carcinogenic property by inducing cellular detoxification pathway [14, *Address correspondence to this author at the Al-Azhar University, Assiut Branch, Faculty of Science, Chemistry Department, Egypt; Tel: 00201006785228; E-mail : ahmedshatat82@yahoo.com 15]. With regard to many of the biologically active copper chelating complexes [16] was the copper (I)-nicotinate that exhibiting antioxidant activity as well as therapeutic pharmaceutical activity against Newcastle diseases [17], anti-inflammatory effect on gastric ulcer [18], reduction of adverse effects of 5-Fluorouracil in patients with hepatocelluler carcinoma [19] and curative effect against induction of fatty liver in experimental animals [20].…”

Section: Introductionmentioning

confidence: 99%

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Protective Effects of Copper (I)-Nicotinate Complex Against Aflatoxicosis

R.¹

2013

TOTOXIJ

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Aflatoxicosis mostly leads to serious clinical signs of malnutrition, growth retardation, and impairment of utilization of nutrients, immunosupression, liver diseases and cancer. Detoxification or prevention of such toxicity is interesting to researchers in change field. In pursuit for an approach, the synthetic copper(I)-nicotinate complex has been evaluated against the traditional Butylated hydroxy toluene (BHT) for possible protective effects as a food additive in induced aflatoxicosed animals. Induction of toxicity in adult rats by AFB 1 60 µg/kg body weight divided on three times a week for consecutive five weeks resulted in marked hepatic necrosis, collagen fibers around portal tract and iron deposits as well as features of general cellular collapse and cirrhosis. The protective effects were tested on two animal groups by associate doses of BHT (0.05 mg / kg B.W.) in one group and copper (I) nicotinate complex (0.4 mg/kg B.W.) in the other. Results showed, in both groups, almost normal histological as well as biochemical markers especially those treated with the copper complex, which suggests that anti-inflammatory copper complex can be used as a protective agent against aflatoxicosis when used in doses resemble those used in pharmaceutical vitamin supplements.

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“…Liver weight, liver trans aminases and alkaline phosphates were decreased and nitric oxides, super oxides; lipid peroxides were changed to normal level. Cu complex was important for renewal of structure and functions [15].…”

Section: Metal Complexes Of Nicotinic Acid and Imidazole:-cu +2 Complmentioning

confidence: 99%