Pharmacokinetic comparison of puerarin after oral administration of Jiawei-Xiaoyao-San to healthy volunteers and patients with functional dyspepsia: influence of disease state

Qin, Feng; Huang, Xi; Zhang, Hongmin; Ren, Peiyu

doi:10.1211/jpp.61.01.0018

Cited by 31 publications

(12 citation statements)

References 11 publications

(23 reference statements)

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“…The most common cause of angina is CHD (5) and ~50% of patients with the disease exhibit chronic stable angina as their initial symptom (6). Recent studies have indicated that angina is one of the disease states that may modify the pharmacokinetics of a drug (7–9). However, the pathway by which angina is regulated by the pharmacokinetics of traditional Chinese medicine is unknown.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic comparison of the vasorelaxant compound ferulic acid following the administration of Guanxin II to healthy volunteers and patients with angina pectoris

Huang

Wang

et al. 2013

Experimental and Therapeutic Medicine

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Coronary heart disease (CHD) is the leading cause of mortality worldwide. The Chinese medicinal formula Guanxin II has been shown to have a favorable effect in the attenuation of angina. The aim of this study was to compare the pharmacokinetics of ferulic acid (FA), which is a vasorelaxant compound present in Guanxin II, in healthy volunteers and patients with angina pectoris following the administration of Guanxin II. Ex vivo experiments were performed in order to investigate the vasorelaxant effect of FA on the human internal mammary artery (IMA) to provide evidence that it is a bioactive component of Guanxin II. Following the oral administration of Guanxin II, the FA levels in the serum were quantified by a simple and rapid high-performance liquid chromatography (HPLC) method. Treatment with FA (10−8−10−3 M) caused a concentration-dependent relaxation of endothelial IMA rings following precontraction with KCl. Statistically significant differences were identified between the pharmaco-kinetic parameters Cmax, t1/2α, t1/2β and t1/2Ka of the healthy volunteers and the patients with angina pectoris following the oral administration of Guanxin II. FA is a bioactive compound absorbed from Guanxin II that attenuates angina pectoris, a condition that may modify the pharmacokinetics of FA. Not only do the pharmacokinetic parameters direct the clinical use of Guanxin II, but they may also be useful for exploring the pathology of angina pectoris.

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Section: Introductionmentioning

confidence: 99%

Pharmacokinetic comparison of the vasorelaxant compound ferulic acid following the administration of Guanxin II to healthy volunteers and patients with angina pectoris

Huang

Wang

et al. 2013

Experimental and Therapeutic Medicine

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“…Of over 128 papers reporting the pharmacokinetics of TCM in MEDLINE [MeSH terms: pharmacokinetics and human and (decoction or herbs or TCM) and English], only 1 involved patients (Qin et al, 2009). Therefore, the clinical pharmacokinetic study of TCM should be a topic of study in the future.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetic study of the prokinetic compounds meranzin hydrate and ferulic acid following oral administration of Chaihu-Shugan-San to patients with functional dyspepsia

Qiu

Huang

Chen

et al. 2011

Journal of Ethnopharmacology

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“…55 55 recently performed a literature review, identified 14 randomized controlled studies in which MXS was used alone or compared with a prokinetic agent, but was unable to draw a conclusion about its efficacy because all studies were of poor quality.…”

Section: Modified Xiaoyao Sanmentioning

confidence: 99%

Complementary and Alternative Medicine for Gastroparesis

Lee

Chen

Yin

2015

Gastroenterology Clinics of North America

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Pharmacokinetic comparison of puerarin after oral administration of Jiawei-Xiaoyao-San to healthy volunteers and patients with functional dyspepsia: influence of disease state

Cited by 31 publications

References 11 publications

Pharmacokinetic comparison of the vasorelaxant compound ferulic acid following the administration of Guanxin II to healthy volunteers and patients with angina pectoris

Pharmacokinetic comparison of the vasorelaxant compound ferulic acid following the administration of Guanxin II to healthy volunteers and patients with angina pectoris

Pharmacokinetic study of the prokinetic compounds meranzin hydrate and ferulic acid following oral administration of Chaihu-Shugan-San to patients with functional dyspepsia

Complementary and Alternative Medicine for Gastroparesis

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