Pharmacokinetic Comparison of Nine Bioactive Compounds of Guanxinshutong Capsule in Normal and Acute Myocardial Infarction Rats

Yang, Yuting; Yang, Jiehong; Fu, Wei; Zhou, Peng; Fang, Mingsun; Wan, Haitong; Zhou, Huifen

doi:10.1007/s13318-022-00777-6

Cited by 5 publications

(1 citation statement)

References 38 publications

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“…Owing to the high sensitivity and stability, modern mass spectrometry coupled with all kinds of hyphenated chromatography separation techniques has a pivotal role in the exploration of in vivo metabolism of active components. 738 – 757 Cheminformatics utilizing computer-aided, high-throughput virtual screening, network-based and machine learning techniques have opened up a new avenue in exploiting naturally-inspired products for lead compound and active components discovery. 758 – 767 A non-targeted metabolomics screening strategy is carried out focusing on the in vivo metabolites that exist in the administrated samples and do not exist in blank biological samples, by exploring the dosage-effect relationships.…”

Section: Metabolic Process Of Active Componentsmentioning

confidence: 99%

Small molecule metabolites: discovery of biomarkers and therapeutic targets

Qiu

Cai

et al. 2023

Sig Transduct Target Ther

189

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Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite signatures that have close proximity to subject’s phenotypic informative dimension, are useful for predicting diagnosis and prognosis of diseases as well as monitoring treatments. The lack of early biomarkers could lead to poor diagnosis and serious outcomes. Therefore, noninvasive diagnosis and monitoring methods with high specificity and selectivity are desperately needed. Small molecule metabolites-based metabolomics has become a specialized tool for metabolic biomarker and pathway analysis, for revealing possible mechanisms of human various diseases and deciphering therapeutic potentials. It could help identify functional biomarkers related to phenotypic variation and delineate biochemical pathways changes as early indicators of pathological dysfunction and damage prior to disease development. Recently, scientists have established a large number of metabolic profiles to reveal the underlying mechanisms and metabolic networks for therapeutic target exploration in biomedicine. This review summarized the metabolic analysis on the potential value of small-molecule candidate metabolites as biomarkers with clinical events, which may lead to better diagnosis, prognosis, drug screening and treatment. We also discuss challenges that need to be addressed to fuel the next wave of breakthroughs.

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