Dietary gallic acid as an antioxidant: A review of its food industry applications, health benefits, bioavailability, nano-delivery systems, and drug interactions

Xiang, Zedong; Guan, Huida; Zhao, Xiang; Xie, Qi; Xie, Zhejun; Cai, Fujie; Dang, Rui; Li, Manlin; Wang, Changhong

doi:10.1016/j.foodres.2024.114068

Cited by 16 publications

(2 citation statements)

References 195 publications

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“…GA is widely distributed in edible plants, possesses potent antioxidant activity and low bioavailability due to rapid absorption and metabolism [44]. However, higher concentrations of GA are toxic [45].…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of Condensed and Hydrolysable Tannins during Early Stages of Zebrafish Development

La Pietra,

Imperatore,

Coccia

et al. 2024

Preprint

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In this study, we present data on the effects of condensed (CTs) and hydrolysable (HTs) tannins, polyphenols extracted from plants, at different concentrations on zebrafish development to identify the range of concentrations with toxic effects. Zebrafish embryos were exposed to CTs and HTs at two different concentration ranges (5.0, 10.0, 20.0 μgL-1 and 5.0, 10.0, 20.0 mgL-1) for 72 h. The toxicity parameters were observed up to 72 h of treatment. The uptake of CTs and HTs by zebrafish larvae was assessed by HPLC analysis. The qRT-PCR analysis was performed to evaluate gene expression of cd63, zhe1 and klf4, involved in the hatching process of zebrafish. CTs and HTs at 5.0, 10.0, and 20.0 μgL-1 were not toxic. On the contrary, at 5.0, 10.0, and 20.0 mgL-1 HTs induced a delayed in hatching starting from 48 h of treatment, while CTs showed a delayed in hatching mainly at 48h. The analysis of gene expression showed a down-regulation in the group exposed to HTs confirming the hatching data. We believe that this study is important to define the optimal doses of CTs and HTs, to be employed in different application fields such as chemical and animal feed industry, and medical science.

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Section: Discussionmentioning

confidence: 99%

Comparative Study of Condensed and Hydrolysable Tannins during Early Stages of Zebrafish Development

La Pietra,

Imperatore,

Coccia

et al. 2024

Preprint

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“…Gallic acid (182) has significant free radical scavenging, anti-inflammatory and antioxidant effects in the body. [45,46] Rhodioloside (200) has neuroprotective, metabolism-regulating and anticancer effects [47][48][49] and paeonol (203) also has anti-inflammatory, metabolism-regulating, anticancer effects and cardiovascular protection. [50] The structures of phenolic compounds in T. sinensis are detailed in Figure 11, and the related information is detailed in Table 8.…”

Section: Phenolic Compoundsmentioning

confidence: 99%

A Review on Traditional Uses, Phytochemistry, Pharmacology and Clinical Application of Tinospora sinensis (Lour.) Merr

Liang,

Guo,

et al. 2024

Chemistry & Biodiversity

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Tinospora sinensis (T. sinensis), whose Tibetan name is “Lezhe”, as a traditional medicine, is widely distributed in China, India and Sri Lanka. It is used for the treatment of rheumatic arthralgia, sciatica, lumbar muscle strain and bruises. Research over the previous decades indicated that T. sinensis mainly contains terpenes, lignans, alkaloids, phenol glycosides and other chemical components. A wide range of pharmacologic activities such as anti‐inflammatory, analgesic, immunosuppressive, anti‐aging, anti‐radiation, anti‐leishmania and liver protection have been reported. However, the scholar’s research on the pharmacodynamic material basis of T. sinensis is relatively weak. Data regarding many aspects such as links between the traditional uses and bioactivities, pharmacokinetics, and quality control standard of active compositions is still limited and need more attention. This review reports a total of 241 compounds, the ethnopharmacology and clinical application of T. sinensis, covering the literature which were searched by multiple databases including Web of Science, PubMed, Google Scholar, Science Direct, CNKI and other literature sources from 1996 to date, with a view to provide a systematic and insightful reference and lays a foundation and inspiration for the application and further in‐depth research of T. sinensis resources.

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Eco-friendly food packaging: gallic acid as a cross-linking agent in PBAT/cellulose composite films

Venkatesan,

Dhilipkumar,

Shankar

et al. 2024

Cellulose

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Dietary gallic acid as an antioxidant: A review of its food industry applications, health benefits, bioavailability, nano-delivery systems, and drug interactions

Cited by 16 publications

References 195 publications

Comparative Study of Condensed and Hydrolysable Tannins during Early Stages of Zebrafish Development

Comparative Study of Condensed and Hydrolysable Tannins during Early Stages of Zebrafish Development

A Review on Traditional Uses, Phytochemistry, Pharmacology and Clinical Application of Tinospora sinensis (Lour.) Merr

Eco-friendly food packaging: gallic acid as a cross-linking agent in PBAT/cellulose composite films

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