Pharmacokinetic comparative study of GAS with different concentration of tetramethylpyrazine and ferulic acid on liver–yang hyperactivity migraine model by blood–brain microdialysis method

Mi, Yahui; Wang, Meijing; Liu, Mingping; Cheng, Hui; Li, Shengqing

doi:10.1016/j.jpba.2020.113643

Cited by 9 publications

(3 citation statements)

References 3 publications

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“…Gastrodia elata 's clinical application and its treatment in cognition-related diseases have been established for a long time. Although the ancients did not have modern diversified ways of drug analysis, through long-term practice, we have found that Gastrodia elata combined with other drugs can increase the utilization rate in the nervous system of the active components of Gastrodia elata , resulting in better efficacy [ 108 ]. In modern times, the ancient prescription is packaged by modern ways, such as Antongshutong capsule.…”

Section: Resultsmentioning

confidence: 99%

Gastrodin and Vascular Dementia: Advances and Current Perspectives

Deng

Chen

Meng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Gastrodia elata, a traditional Chinese medicine, has been widely used since ancient times to treat diseases such as dizziness, epilepsy, stroke, and memory loss. Gastrodin, one of the active components of Gastrodia elata, has been used in the treatment of migraine, epilepsy, Parkinson’s disease, dementia, and depression in recent years. It can improve cognitive function and related neuropsychiatric symptoms through various effects and is considered as a promising treatment for dementia. Vascular dementia is a kind of severe cognitive impairment syndrome caused by vascular factors, and it is the dementia syndrome with the largest number of patients besides Alzheimer’s disease. Although there is still a lack of evidence-based explorations, the paper reviewed the mechanism and methods of gastrodin in the treatment of vascular dementia, providing a reference for clinical therapy.

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Section: Resultsmentioning

confidence: 99%

Gastrodin and Vascular Dementia: Advances and Current Perspectives

Deng

Chen

Meng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Its BBB permeation index is −2.29 (less than −0.3 is considered unable to permeate the BBB). After administration, the amount of gastrodin in the brain is very small, and it is rapidly degraded and metabolised [ 31 ]. In the past, it was thought that gastrodin may act by degrading into gastrodin aglycones, which can pass through the BBB more easily; however, this hypothesis has since been overturned and gastrodin has been determined to act alone [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Gastrodin facilitates recovery of neurological function of MCAO rats through upregulating miR-20a-5p/XIAP pathway via exosome

Nan

Zhu

et al. 2023

NeuroReport

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Cerebral infarction (CI) is characterised by high morbidity, mortality, and disability rates. Recently, Chinese medicine has been widely used and has gained satisfactory results in the treatment of CI. Our previous study showed that gastrodin could facilitate the recovery of neurological function in middle cerebral artery occlusion (MCAO) rats. This study explores this mechanism. SD rats were separated into control, sham, model, and gastrodin groups. After MCAO surgery, the gastrodin group was administered gastrodin (100 mg/kg), and after 1/3/7 days, the ischaemic hemisphere and serum was collected, and then we extracted the circulating exosomes from the serum. We then tested the levels of XIAP (x-linked inhibitor of apoptosis protein), IAP binding proteins (SMAC, HtrA2, ARTs), and miR-20a-5p (a gastrodin potential effect target) in the brain tissues, circulating exosomes, and serum using various methods. Our results showed that circulating exosomes can penetrate the blood-brain barrier (BBB) and that gastrodin can upregulate the amount of miR-20a-5p in circulating exosomes. The circulating exosomes penetrate the BBB and upregulate the expression of XIAP in the ischaemic hemisphere. Gastrodin can also decrease the amount of IAP binding proteins (SMAC, HtrA2, ARTs). Gastrodin can increase the amount of miR-20a-5p in circulating exosomes, which penetrates the BBB and upregulates XIAP expression in the ischaemic hemisphere. By inhibiting apoptosis of neurones, it can facilitate the recovery of neurological function in MCAO rats.

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“…It shows an ideal therapeutic effect on cardiovascular and cerebrovascular diseases, and is also used as a preventive medicine to supply the vitamins necessary to maintain tness [3] . In clinical practice, Ligusticum chuanxiong is widely used to treat thromboembolism heart diseases [4] , headache [5,6] , wind-damp [7] . Recent studies have found that the active metabolites of Ligusticum chuanxiong including ligustrazine [8] , ferulic acid [9] , ligustilide [10] , polysaccharide and the others [11] .…”

Section: Introductionmentioning

confidence: 99%

Transcriptome Comparison of Rhizome and Leaf of Rhizome of Ligusticum Chuanxiong on the Effects of Active Metabolites

Hao

cai

et al. 2021

Preprint

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BackgroundThe rhizome of Ligusticum chuanxiong is a well-known traditional Chinese medicine. The major bioactive compounds found in Ligusticum chuanxiong are Ferulic Acid with 4- hydroxyl -3- methoxybenzene acrylic acid. However, the epigenetic mechanisms and biosynthetic pathways of active metabolites based on the transcriptomic analysis of Ligusticum chuanxiong rhizome have remained unclear. To clarify the key genes in rhizome formation and active metabolite synthesis pathways of Rhizome of Ligusticum chuanxiong, we focus on the change between the investigate the rhizome and leaf of Ligusticum chuanxiong through transcriptomic analysis.MethodsThe RNA extracted from rhizomes and leaves of Ligusticum chuanxiong were sequenced using the Illumina platform, yielding 295,725 unique transcripts with N50 of 778 bp. The transcripts against annotation databases including GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) to identify differentially expressed genes (DEGs).Resultsystematic analysis of transcriptome profiles revealed that a total of 1707 differentially expressed unigenes were found in the two tissues, among which 1246 were down-regulated and 462 were up-regulated. Remarkably, some DEGs are enriched in the biosynthetic pathway of phenylalanine ammonia lyase, one of the key enzymes in the pathway of ferulic acid synthesis.ConclusionsThrough the transcriptome analysis, we have identified the regulatory mechanisms and epigenetic influences in the secondary metabolic biosynthetic pathway of Ligusticum chuanxiong. Among them, DEGs analysis revealed ferulic acid and other secondary metabolites are some of the major products in the biosynthetic pathway of Ligusticum chuanxiong.

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Pharmacokinetic comparative study of GAS with different concentration of tetramethylpyrazine and ferulic acid on liver–yang hyperactivity migraine model by blood–brain microdialysis method

Cited by 9 publications

References 3 publications

Gastrodin and Vascular Dementia: Advances and Current Perspectives

Gastrodin and Vascular Dementia: Advances and Current Perspectives

Gastrodin facilitates recovery of neurological function of MCAO rats through upregulating miR-20a-5p/XIAP pathway via exosome

Transcriptome Comparison of Rhizome and Leaf of Rhizome of Ligusticum Chuanxiong on the Effects of Active Metabolites

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