Pharmacokinetic characteristics of emodin in polygoni Multiflori Radix Praeparata

Wang, Dongpeng; Duan, Jufeng; Chen, Xiaojing; Liu, Kaiqi; Guo, Yingying; Shi, Run; Li, Sha; Liu, Ming; Zhao, Lian; Li, Bei; Hu, Haiming; Li, Minglun; Feng, Yibin; Li, Hongliang; Wang, Xuanbin

doi:10.1016/j.jep.2022.115945

Cited by 1 publication

(1 citation statement)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Immune deficiency refers to the state in which the body does not produce an immune response or has a low immune response against antigens, which makes it susceptible to infections, such as bacteria, viruses, and fungi, and even tumors . In addition to being the organ for digesting and absorbing nutrients, the intestine contains over 70% of the body’s immune cells, which makes it the largest immune organ. − The integrity of the intestinal mucosal barrier is the foundation for intestinal immunity and forms a rigorous defense system that can prevent harmful substances and pathogens from invading the body. Thus, it is essential to maintain the integrity of the intestinal mucosal barrier.…”

Section: Introductionmentioning

confidence: 99%

Atractylodes lancea Rhizome Polysaccharide Alleviates Immunosuppression and Intestinal Mucosal Injury in Mice Treated with Cyclophosphamide

Wang,

Dong,

Xie

et al. 2023

J. Agric. Food Chem.

Self Cite

View full text Add to dashboard Cite

Plant-derived polysaccharides, such as Atractylodes lancea rhizome polysaccharide (ALP), are good immune regulators. However, the immune regulatory mechanism of the ALP is unknown. This study aimed to evaluate the effects of ALP on the intestinal mucosal barrier and intestinal mucosal immunity of immunosuppressed mice. We also compared the activity of raw Atractylodes lancea rhizome polysaccharide (SALP) with wheat bran processed bran-fried Atractylodes lancea rhizome polysaccharide (FALP; both at 1.2 g/kg/d for mice). Our results showed that ALP effectively increased the immune organ index and blood cell count, stimulated the secretion of cytokines, and promoted the expression of occludin and zonula occludens-1 (ZO-1). ALP also promoted the expression of T cells and the secretion of sIgA. Furthermore, ALP alleviated the gut microbiota disorder in Cy-treated mice and increased the relative abundances of Lactobacillus and Faecalibaculum. ALP reversed the decrease in the level of SCFAs and promoted the expression of G protein-coupled receptor 43 (GPR43). To our knowledge, this study was the first to explore how the ALP protects the intestinal mucosal barrier and enhances intestinal mucosal immunity by alleviating the gut microbiota imbalance and metabolic disorders of SCFAs. FALP was more therapeutic than SALP, suggesting that FALP could be developed as a promising functional food component.

show abstract