Pharmacokinetic behavior of marbofloxacin after intravenous, subcutaneous and intramuscular administrations in llamas (Lama glama)

Rubio-Langre, Sonia; Lucas, J. J. De; Litterio, Nicolás Javier; Aguilar, Soledad; Boggio, Juan Carlos; Andrés, M. I. San

doi:10.1016/j.smallrumres.2012.04.021

Cited by 10 publications

(9 citation statements)

References 24 publications

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“…Polyexponential equations were fitted to the plasma concentration-time curves, and the number of exponential terms was determined by the application of residual sum of squares (R 2 ) and Akake's information criterion. The elimination half-life (t 1/2β ) was calculated by t 1/2β = 0.693/β (Rubio-Langre et al, 2012). All values are presented as means ± standard deviation (SD).…”

Section: Pharmacokinetic Analysismentioning

confidence: 99%

Study on the pharmacokinetics and metabolism of costunolide and dehydrocostus lactone in rats by HPLC‐UV and UPLC‐Q‐TOF/MS

Zhang

Wang

et al. 2014

Biomedical Chromatography

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A method based on high-performance liquid chromatography coupled with ultraviolet detection was developed for studying the pharmacokinetics of costunolide (Cos) and dehydrocostus lactone (Dehy) in rats after intravenous (i.v.) administration. Following i.v. administration, the maximum plasma concentrations of Cos and Dehy were observed to be 12.29 ± 1.47 and 5.79 ± 0.13 µg/mL, respectively. The bioavailability of Cos was larger than that of Dehy; however, the clearance and the volume of distribution of Dehy were much larger than those of Cos. An ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry system with automated MS(E) (E represents collision energy) data analysis software (MetaboLynx(TM)) was used to analyze and identify the metabolites of Cos and Dehy in vivo. Four metabolites of Cos and six metabolites of Dehy were discovered from the plasma, urine and feces of rats. The main metabolic pathway of Cos was phase II biotransformation, but the main metabolic pathways of Dehy was phase І biotransformation. Two sequential desaturations and N-acetylcysteine conjugation were the common metabolic pathways of Cos and Dehy in rats. This information may be useful for the further development of the two drug candidates.

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Section: Pharmacokinetic Analysismentioning

confidence: 99%

Study on the pharmacokinetics and metabolism of costunolide and dehydrocostus lactone in rats by HPLC‐UV and UPLC‐Q‐TOF/MS

Zhang

Wang

et al. 2014

Biomedical Chromatography

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“…Volumes of distribution values appeared to be similar among different ages evaluated in this study. Moreover, in all cases Vd and Vss were apparently higher than reported Vss in adult llamas of 0.75 ± 0.21 L/kg (Rubio‐Langre et al., ). These differences could be related with higher total body water and lower plasmatic albumin content in young animals.…”

Section: Discussionmentioning

confidence: 45%

“…There are few studies assessing the pharmacokinetics of fluoroquinolones in camelids. These include enrofloxacin, danofloxacin, marbofloxacin, and moxifloxacin in camels (Abd El‐Aty et al., ; Aliabadi, Ali, Landoni, & Lees, ; Gavrielli, Yagil, Ziv, Creveld, & Glickman, ; Laraje et al., ), enrofloxacin in alpacas (Gandolf, Papich, Bringardner, & Atkinson, ) and enrofloxacin and marbofloxacin in llamas (Christensen, Smith, Murdane, & Hollingshead, ; Rubio‐Langre et al., ). In these studies, some authors reported pharmacokinetic differences between camelids and other ruminant species, such as cattle, sheep, or goats, and were attributed to a variable permanence of the drug in the organism.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic evaluation of marbofloxacin after intravenous administration at different ages in llama crias, and pharmacokinetic/pharmacodynamic analysis by Monte Carlo simulation

Rubio-Langre

Aguilar-Sola

Lorenzutti

et al. 2018

Vet Pharm & Therapeutics

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In llama crias (tekes), Escherichia coli and Staphylococcus aureus are major pathogens, and marbofloxacin could be a suitable choice. The objectives of this study were (a) to evaluate the serum pharmacokinetics of marbofloxacin (5 mg/kg) after intravenous administration in tekes and simulate a multidose regimen; (b) to emulate pharmacokinetic profiles after single dose and steady-state conditions by Monte Carlo simulation (c) to determine the MIC of regional strains of Escherichia coli and Staphylococcus aureus; (d) to perform a PK/PD analysis by Monte Carlo simulation. Pharmacokinetics of marbofloxacin was evaluated in six animals at 3, 10, 24, 50, and 80 days after birth. Marbofloxacin were determined by HPLC. A steady-state multi-dose simulation was carried out, and concentration-time profiles were generated by Monte Carlo simulation. MIC of marbofloxacin against regional E. coli and S. aureus strains were also determined. Finally, a PK/PD analysis was conducted by Monte Carlo simulation. After pharmacokinetic analysis, clearance showed a trend to increase (0.14 and 0.18 L kg hr ), and AUC (36.74 and 15.21 μg hr ml ) and Vss (3.06 and 3.37 L/kg) trended to decrease at 3 and 80 days-old, respectively, showing accumulation ~50% in animals with 3 days. All strains tested of E. coli (MIC = 0.06 μg/ml) and S. aureus (MIC = 0.25 μg/ml) were susceptible to marbofloxacin. PK/PD analysis suggests that the therapeutic regimen of marbofloxacin could be effective for infections caused by E. coli strains in animals between 3 and 80 days, with a CFR for C /MIC > 10 of 100% and for AUC /MIC > 125 of 99.99%; and for infections produced by S. aureus in animals between 3 and 24 days old, with a CFR for C /MIC > 10 of 93.08% and for AUC /MIC > 60 of 97.01%, but a higher dose should be used in older animals, because PK/PD endpoints were not met.

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“…The distribution half-lives of OTC in F. chinensis were 1.82 h in females and 2.50 h in males, both longer than those of antibacterial agents such as enroflxacin, florfenicol, sulfamethoxazole, marbofloxacin, and miloxacin (Liang et al, 2012;Rubio-Langre et al, 2012;Li et al, 2008) but shorter than sulphamonomethoxine in other species.…”

Section: Discussionmentioning

confidence: 96%

Lack of gender effect on the pharmacokinetics of oxytetracycline in Fenneropenaeus chinensis after intramuscular administration

Sun

Chang

et al. 2015

J. Ocean Univ. China

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Fenneropenaeus chinensis, an economically important shrimp species, currently suffers from epizootic diseases due to high density stocking and bacterial infections. Oxytetracycline (OTC) has been widely used to treat various systemic bacterial infections in shrimp farming. In the present study, the effect of gender on pharmacokinetics of OTC in F. chinensis was investigated. The OTC concentrations in hemolymph of shrimp after single intramuscular administration (75 mg OTC per kg body weight) were analyzed by high performance liquid chromatography and best described with a two-compartment open model which is characterized by a short elimination half-life, low clearance, and a relatively large apparent volume of distribution. The pharmacokinetic equations were C t = 58.54e −0.38t + 11.67e −0.04t for females; and C t = 27.94e −0.28t + 14.87e −0.04t for males. The distribution and elimination half-lives of OTC were 1.82 and 19.58 h, respectively, in females and 2.50 and 16.11 h, respectively, in males at 22℃. The areas under the drug concentration curve were 480 mg L −1 h −1 in females and 430 mg L −1 h −1 in males. The total body clearance of the drug was 157.11 mL kg −1 h −1 in females and 172.47 mL kg −1 h −1 in males. The apparent volume distribution was 4.44 in females and 4.01 L kg −1 in males. There was no significant difference in pharmacokinetic parameters between female and male shrimps, indicating that there is no need to consider the gender effect in clinical use of OTC in F. chinensis farming.

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Pharmacokinetic behavior of marbofloxacin after intravenous, subcutaneous and intramuscular administrations in llamas (Lama glama)

Cited by 10 publications

References 24 publications

Study on the pharmacokinetics and metabolism of costunolide and dehydrocostus lactone in rats by HPLC‐UV and UPLC‐Q‐TOF/MS

Study on the pharmacokinetics and metabolism of costunolide and dehydrocostus lactone in rats by HPLC‐UV and UPLC‐Q‐TOF/MS

Pharmacokinetic evaluation of marbofloxacin after intravenous administration at different ages in llama crias, and pharmacokinetic/pharmacodynamic analysis by Monte Carlo simulation

Lack of gender effect on the pharmacokinetics of oxytetracycline in Fenneropenaeus chinensis after intramuscular administration

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