Pharmacokinetic and bioequivalence evaluation of two formulations of 100 mg trimebutine maleate (Recutin™ and Polybutin™) in healthy male volunteers using the LC–MS/MS method

Discovery of A Novel Trimebutine Metabolite and its Impact on N -Desmethyltrimebutine Quantification by LC–MS/MS

“…Although several mass spectrometry-based HPLC methods are published for trimebutine and its metabolite NDMT in human plasma, none of these papers mentioned the presence of a highly unstable metabolite [33][34][35]. This discovery might elucidate unknown metabolite pathways for trimebutine but may also raise concerns on previously performed studies for trimebutine.…”

Safety, Tolerability and Pharmacokinetics of Trimebutine 3-Thiocarbamoylbenzenesulfonate (GIC-1001) in a Randomized Phase I Integrated Design Study: Single and Multiple Ascending Doses and Effect of Food in Healthy Volunteers

“…12 The pharmacokinetic parameters of the trimebutine moiety of GIC-1001 observed after single-dose administration are consistent with the reported pharmacokinetic profile of trimebutine maleate: peak plasma concentrations reached in $ 1 hour and short plasma half-life for both trimebutine and N-monodesmethyl-trimebutine. 12,[16][17][18] An important element is the apparent second peak of absorption observed at $ 10 hours' postdose for trimebutine ( Figure 3). This second peak of absorption could be explained by an enterohepatic cycling of the molecule.…”

Targeted Intermediates of Eudesmic Acid: Synthesis and X-ray Investigations

“…Aim of this work is developing effective methods for synthesis of 2,6-dinitro-3,4,5 which has reactive carboxylic g Oct There is in medicine practice more than 20 drugs are successfully used, such as: trimebutine with antimuscarinic effect [2] and its maleic acid saltrecutin, polybutin [3], trimetozine (sedative activity) [4,5] is used in Europe since 1959 and has been used in the treatment of anxiety [6,7], dilazep (vasodilator) reuptake inhibition [8], troxipide is a drug used in the treatment of gastroesophageal reflux disease and it is novel systematic nonantisecretory gastric cytoprotective agent with antiinflammatory properties [9][10][11][12][13][14], methoserpidine [15] is an antihypertensive drug related to reserpine and its analogues [16] some 3,4,5trimethoxybenzoic acid derivatives have been synthesized and studied their activity on the central nervous system [17]. Discussion of literatures shows c acid and its derivatives are very interest and important synthons for creation of pharmacologically active drugs.…”