Pharmacokinetic and bioavailability studies of α-viniferin after intravenous and oral administration to rats

Fan, Yuyang; Zhao, Lulu; Huang, Xuhua; Jia, Qi; Wang, Wei; Gao, Mengyuan; Jia, Xiaohua; Chang, Yan‐xu; Ouyang, Hongwei; He, Jun

doi:10.1016/j.jpba.2020.113376

Cited by 9 publications

(8 citation statements)

References 12 publications

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“…Several different forms of viniferin exist (Figure 1). The α-viniferin form is an oligostilbene of trimeric resveratrol [6] and was first found in Caraganachamlagu Lam as a compound that exhibits anti-inflammatory activities [7]. Furthermore, one of the major products of resveratrol-derived dehydrodimers is called δ-viniferin [8,9].…”

Section: Introductionmentioning

confidence: 99%

Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy

et al. 2022

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Viniferin is a resveratrol derivative. Resveratrol is the most prominent stilbenoid synthesized by plants as a defense mechanism in response to microbial attack, toxins, infections or UV radiation. Different forms of viniferin exist, including alpha-viniferin (α-viniferin), beta-viniferin (β-viniferin), delta-viniferin (δ-viniferin), epsilon-viniferin (ε-viniferin), gamma-viniferin (γ-viniferin), R-viniferin (vitisin A), and R2-viniferin (vitisin B). All of these forms exhibit a range of important biological activities and, therefore, have several possible applications in clinical research and future drug development. In this review, we present a comprehensive literature search on the chemistry and biosynthesis of and the diverse studies conducted on viniferin, especially with regards to its anti-inflammatory, antipsoriasis, antidiabetic, antiplasmodic, anticancer, anti-angiogenic, antioxidant, anti-melanogenic, neurodegenerative effects, antiviral, antimicrobial, antifungal, antidiarrhea, anti-obesity and anthelminthic activities. In addition to highlighting its important chemical and biological activities, coherent and environmentally acceptable methods for establishing vinferin on a large scale are highlighted to allow the development of further research that can help to exploit its properties and develop new phyto-pharmaceuticals. Overall, viniferin and its derivatives have the potential to be the most effective nutritional supplement and supplementary medication, especially as a therapeutic approach. More researchers will be aware of viniferin as a pharmaceutical drug as a consequence of this review, and they will be encouraged to investigate viniferin and its derivatives as pharmaceutical drugs to prevent future health catastrophes caused by a variety of serious illnesses.

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Section: Introductionmentioning

confidence: 99%

Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy

et al. 2022

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“…α-Viniferin is a food-derived metabolite. More evidence has shown that α-viniferin displayed a broad range of pharmacological activities, including anti-Alzheimer’s disease and anti-inflammatory [ 32 , 33 ]. However, its biological function in toxoplasmosis needs further exploration.…”

Section: Discussionmentioning

confidence: 99%

Investigation of urine metabolome of BALB/c mouse infected with an avirulent strain of Toxoplasma gondii

Zhou

Huang

et al. 2022

Parasites Vectors

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Background The protozoan parasite Toxoplasma gondii is a major concern for human and animal health. Although the metabolic understanding of toxoplasmosis has increased in recent years, the analysis of metabolic alterations through noninvasive methodologies in biofluids remains limited. Methods Here, we applied liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based metabolomics and multivariate statistical analysis to analyze BALB/c mouse urine collected from acutely infected, chronically infected and control subjects. Results In total, we identified 2065 and 1409 metabolites in the positive electrospray ionization (ESI +) mode and ESI − mode, respectively. Metabolomic patterns generated from principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) score plots clearly separated T. gondii-infected from uninfected urine samples. Metabolites with altered levels in urine from T. gondii-infected mice revealed changes in pathways related to amino acid metabolism, fatty acid metabolism, and nicotinate and nicotinamide metabolism. Conclusions This is the first study to our knowledge on urine metabolic profiling of BALB/c mouse with T. gondii infection. The urine metabolome of infected mouse is distinctive and has value in the understanding of Toxoplasmosis pathogenesis and improvement of treatment. Graphical Abstract

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“…However, different studies on stilbenes have shown that the second absorption peak of the native form occurs at different times depending on the molecule, the doses and the animal model used. This second absorption peak appeared around 60 min after oral administration of pterostilbene [63] and resveratrol [64,65] or more than 10 h for the trimer, α-viniferine [66], for example. Supplemental experiments such as bile analysis could confirm this hypothesis and determine in what form the molecule undergoes this enterohepatic circulation [67,68].…”

Section: Discussionmentioning

confidence: 99%

Trans-ε-Viniferin Encapsulation in Multi-Lamellar Liposomes: Consequences on Pharmacokinetic Parameters, Biodistribution and Glucuronide Formation in Rats

et al. 2021

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Trans-ε-viniferin (εVin) is a resveratrol dimer exhibiting promising biological activities for human health. Its bioavailability being low, the development of encapsulation methods would be used to overcome this issue. The aim of this study was to measure the consequences of the encapsulation of εVin in multilamellar liposomes on its pharmacokinetic parameters, metabolism and tissue distribution in rats. After oral administration of εVin (20 mg/kg body weight), either as free or encapsulated forms, plasmas were sequentially collected (from 0 to 4 h) as well as liver, kidneys and adipose tissues (4 h after administration) and analyzed by LC-HRMS. The glucuronide metabolites (εVG) were also produced by hemisynthesis for their quantification in plasma and tissues. The encapsulation process did not significantly modify the pharmacokinetic parameters of εVin itself. However, a significant increase of the T1/2 was noticed for εVG after administration of the encapsulated form as compared to the free form. An accumulation of εVin and εVG in adipose tissues was noticed, and interestingly a significant increase of the latter in the mesenteric one after administration of the encapsulated form was highlighted. Since adipose tissues could represent storage depots, and encapsulation allows for prolonging the exposure time of glucuronide metabolites in the organism, this could be of interest to promote their potential biological activities.

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Pharmacokinetic and bioavailability studies of α-viniferin after intravenous and oral administration to rats

Cited by 9 publications

References 12 publications

Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy

Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy

Investigation of urine metabolome of BALB/c mouse infected with an avirulent strain of Toxoplasma gondii

Trans-ε-Viniferin Encapsulation in Multi-Lamellar Liposomes: Consequences on Pharmacokinetic Parameters, Biodistribution and Glucuronide Formation in Rats

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