Pharmacognostical standardization and antidiabetic activity of <i>Syzygium cumini</i> (Linn.) barks (Myrtaceae) on streptozotocin-induced diabetic rats

Tripathi, Akhilesh; Kohli, Seema

doi:10.1515/jcim-2014-0011

Cited by 26 publications

(18 citation statements)

References 8 publications

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“…500 mg/kg of these extracts controlled and brought FBG to near-normal range after 21 days of administration. 6 The anti-diabetic activities of stem beverage can be ascribed to the presence of myricetin, quercetin, beta-sitosterol, gallic acid, cyanidin, delphinidin, petunidin and malvidin glycosides, catechin, quercetin, and lupeol etc. in the beverage.…”

Section: Discussionmentioning

confidence: 99%

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2017

IJPSR

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ABSTRACT:In view of therapeutic values associated with Syzygium cumini and increasing consumer demand for functional foods, a non-conventional alcoholic beverage prepared from the stem of Syzygium cumini was evaluated for its efficacy against streptozotocin-induced diabetes mellitus in male wistar rats. The beverage was observed to be safe for consumption as it did not produce any anomalies in the biochemical markers of liver and kidney of normal rats, rather exerted protective effects on hepatic and renal functions by improving the levels of biochemical indicators. After an oral administration of a daily single of dose of 4ml/kg for a period of 30 days, stem beverage was able to rectify the abnormalities in blood glucose levels, lipid profile and atherogenic index of diabetic rats. The beverage also arrested the deviations in hepatic and renal functions of diabetic rats. Histological studies of pancreas also confirmed the anti-diabetic behaviour of stem beverage. The pharmacological properties of the beverage can be ascribed to the presence of various phenolics and tannins in it. The use of this beverage for the management of diabetes mellitus and associated dyslipidemia is suggested.

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Section: Discussionmentioning

confidence: 99%

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2017

IJPSR

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“…before oral glucose loading significantly decreased (p<0.001) the rise in postprandial blood glucose levels in treated rats as compared to control rats however the result was less significant than glibenclamide. Every day, continuous oral treatment of STZ-induced diabetic with various Syzygium cumini (L.) extract for 3 weeks lead to significant reductions in fasting blood glucose levels as compared to diabetic controls 42 .…”

Section: Storage and Marketingmentioning

confidence: 97%

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2018

IJPSR

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Syzygium cumini (L.) is a widely used medicinal plant for the management of various diseases. Syzygium cumini posses various chemical constituent which are responsible for pharmacological activity. This plant reported to possess many pharmacological activities like antidiabetic activity, anti-oxidant, anti-inflammatory, anti-diarrhoeal activity, antiviral, antifertility activity, gastroprotective, antipyretic, antihistaminic, antimicrobial and antiplaque. The present review presents specific information on morphology of plant, cultivation of plant, traditional uses and pharmacological actions of S. cumini (L.). Further applications of Syzygium cumini (Linn.) in the field of novel drug delivery has been also elaborated in the review. Apart from its application in the management of various ailments there is need to explore chemical and toxicity concern of Syzygium cumini (Linn.). INTRODUCTION: There has been an increasing demand for health promoting food products by the consumers all over the world. This has led to the new hybrid term between nutrients and pharmaceuticals, 'nutraceuticals' coined by Dr. Stephen L. DeFelice, in the year 1989 1. Nutraceuticals are diet supplements that deliver a concentrated form of a bioactive component from a food and used with the purpose of enhancing health in dosages that sometimes exceeds that of the normal foods 2. Medicinal plants have been the part and parcel of human society to combat diseases since the dawn of human society to combat diseases since the dawn of human civilization 3 .

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“…The standard drug glibenclamide 2.5 mg/kg used in the study lowered fasting glucose to 106.33 mg/dl. 26…”

Section: Bark Extractmentioning

confidence: 99%

“…None of the extracts studied have shown any sign of toxicity or mortality during the one-week observation period. 26…”

Section: Toxicity Studies With Sc Bark Extractmentioning

confidence: 99%

Syzygium cumini (jamun) therapeutic potential: a comprehensive review on phytochemical constituents and emphasis on its pharmacological actions related to diabetic intervention

Asanaliyar¹,

Nadig²

2020

Int J Basic Clin Pharmacol

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Syzygium cumini or Eugenia Jambolana Lam is a traditional medicinal plant very native to the Indian and Asian sub-continent. It is commonly known as black plum or jamun. Various plants parts of the tree are known for ethno-medicinal uses, and in particular, the fruits of Jamun tree are well known for medicinal uses and preparation of health drinks. Studies have shown that the berries contain carbohydrates, minerals and the pharmacologically active phytochemicals. The active phytochemical includes flavonoids, terpenes, and anthocyanins. Ayurvedic and Indian Folk Medicine have already mentioned the use of jamun for diabetic treatment even before the advent of insulin. The bark, fruit pulp, seeds and the leaves are evaluated in the crude form as well as extracts in various diabetic models. Further, bioactive phytochemicals are extracted using in vitro assays, some of them such as vitalboside-A, mycominose are also characterized with spectroscopic analysis. This review article is intended to compile Syzygium cumini’s therapeutic potential with special emphasis on the phytochemical constituents and its pharmacological activities related to diabetic intervention through recent studies conducted in last one decade. It also addresses the clinical and toxicological studies.

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Pharmacognostical standardization and antidiabetic activity of Syzygium cumini (Linn.) barks (Myrtaceae) on streptozotocin-induced diabetic rats

Abstract: This study brings out the evidence regarding phytochemistry and pharmacological activities of Syzygium cumini.

Cited by 26 publications

References 8 publications

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Syzygium cumini (jamun) therapeutic potential: a comprehensive review on phytochemical constituents and emphasis on its pharmacological actions related to diabetic intervention

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