Pharmacognostical evaluation of Psoralea corylifolia Linn. seed

Shrestha, Sahara; Jadav, Hasmukh R; Bedarkar, Prashant; Patgiri, Biswajyoti; Harisha, C R; Chaudhari, Swapnil; Prajapati, PK

doi:10.1016/j.jaim.2017.05.005

Cited by 12 publications

(8 citation statements)

References 11 publications

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“…The morphological feature of liver tissues is direct and critical evidence for the diagnosis of liver damage ( Shrestha et al, 2018 ). As shown in Figure 1A , 90% of mice in the PFE group demonstrated vacuolation.…”

Section: Resultsmentioning

confidence: 99%

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Five Constituents Contributed to the Psoraleae Fructus-Induced Hepatotoxicity via Mitochondrial Dysfunction and Apoptosis

et al. 2021

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Backgrounds: Psoraleae Fructus (PF)-induced hepatotoxicity has been reported in clinical and animal experiments. However, the hepatotoxic constituents and mechanisms underlying PF-induced toxicity have remained unclear. Therefore, this study explored the potentially toxic PF components and revealed their relative mechanisms.Methods: The hepatotoxicity of PF water (PFW) and ethanol (PFE) extracts was compared using Kunming mice. The different compositions between PFW and PFE, which were considered toxic compositions, were identified using the UHPLC-Q-Exactive MS method. Then, L02 and HepG2 cell lines were used to evaluate the toxicity of these compositions. Cell viability and apoptosis were determined through the Cell Counting Kit-8 (CCK-8) assay and flow cytometry, respectively. An automatic biochemical analyzer detected the aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). Lastly, we used high-content screening (HCS) to determine the levels of reactive oxygen species (ROS), lipid, and mitochondrial membrane potential (MMP).Results: The ethanol extraction process aggravated the hepatotoxicity of PF, causing more severe injuries. The content of psoralen, isopsoralen, bavachin, psoralidin, bavachinin, neobavaisoflavone, and bakuchiol was higher in the PFE than PFW. Bavachin, psoralidin, bavachinin, neobavaisoflavone, and bakuchiol induced cell apoptosis and the AST, ALT, and ALP leakages. Furthermore, these five constituents increased intracellular lipid accumulation and ROS levels but decreased the MMP level.Conclusion: The ethanol extraction process could induce severe PF hepatotoxicity. Bavachin, psoralidin, bavachinin, neobavaisoflavone, and bakuchiol are the main hepatotoxic ingredients. This mechanism could be associated with oxidative stress and mitochondrial damage-mediated apoptosis. Taken together, this study provides a basis for the clinical application of PF that formulates and improves its herbal standards.

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Section: Resultsmentioning

confidence: 99%

“…The morphological feature of liver tissues is direct and critical evidence for the diagnosis of liver damage (Shrestha et al, 2018).…”

Section: Evaluation Of the Liver Injury Induced By Psoraleae Fructusmentioning

confidence: 99%

Five Constituents Contributed to the Psoraleae Fructus-Induced Hepatotoxicity via Mitochondrial Dysfunction and Apoptosis

et al. 2021

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“…Babchi or Bakuchi (Psorylea corylifolia) is a plant found across India, China and Southern Africa, and is used in traditional Ayurdevic medicine for treatment of dermatological conditions such as psoriasis, vitiligo and leprosy, via oral or topical routes. 1 , 2 It is employed as such because it has anti-inflammatory, anti-oxidant and immune-modulatory properties. 1 , 2 The psoralen containing furocoumarins promote pigmentation.…”

Section: Discussionmentioning

confidence: 99%

“… 1 , 2 It is employed as such because it has anti-inflammatory, anti-oxidant and immune-modulatory properties. 1 , 2 The psoralen containing furocoumarins promote pigmentation.…”

Section: Discussionmentioning

confidence: 99%

Babchi oil-induced phytophotodermatitis mimicking burn injury

2021

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Babchi (Psorylea corylifolia) is occasionally used by patients as a herbal treatment in conditions such as psoriasis and vitiligo, due to its anti-inflammatory, anti-oxidant and immune-modulatory properties (Shrestha et al., 2018; Chopra et al., 2013). Due to its psoralen containing furocoumarins, it has the potential to induce photosensitive reactions. We present the first reported case of Babchi-induced phytophotodermatitis in the UK, presenting as sunburn.

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“…report the results of a randomized controlled trial comparing bakuchiol to retinol in treatment of facial wrinkles and pigmentation . Bakuchiol is a natural substance derived from a few different plants, most commonly Psoralea corylifolia , and it is in use in Ayurvedic medicine . Bakuchiol is thought to act in skin as a functional analogue of retinoids by inducing similar genetic targets.…”

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confidence: 99%