Pharmacognostical and Phytochemical Evaluation of Gandhakadi Yoga

Kalara, Jigna R; Kori, VK; Patel, K G; Harisha, C R; Shukla, VJ

doi:10.31254/phyto.2019.8209

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…Mooradian (1993) reported that steroid compounds are an index of antioxidant properties of these compounds. (Selvin & Lipton, 2004;Fayaz et al, 2005;Somepalli et al, 2007;Adaikalaraj et al, 2011).…”

Section: Phytochemical Resultsmentioning

confidence: 99%

The Potential Secondary Metabolites of Macroalgae Sargassum polycystum C. Agardh (1824) from the coast of West Aceh as Raw Material of Body Scrub

Gazali

Nurjanah²,

Husni³

et al. 2022

JFS

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Sargassum polycystum is one brown seaweed with a rich alginate source. The previous study showed that S. polycystum could be used as a cosmeceutical raw material because of its natural attribute and safe. S. polycystum always grows in many coastal of Indonesia. This study aims to characterise brown seaweed (S. polycystum) as the raw material of the body scrub. The research method includes the extraction, phytochemical assay, antioxidant assay, and total phenolic content-the phytochemical screening-detected alkaloid and steroid compounds in S. polycystum extract. The antioxidant activity by using the CUPRAC method showed the ethanol extract was 53.55±1.07 µM/g and FRAP was 201.95±6.33 µM/g with total phenolic content was 177.647±21.39 Mg GAE/g. We compared the antioxidant capacity of the body scrub by adding brown seaweed of S. polycystum 7% (S7) used the CUPRAC method was 34.23±0.33 µM/g, and FRAP was 124.05±1.87 µM/g with total phenolic content was 416.31±78.44 Mg GAE/g. Kruskal Wallis's analysis showed that adding brown seaweed S. polycystum with different formulas influenced the panellist's preference for smearing ability, odor, texture, colour, and consistency parameters. According to the Mean rank obtained, the level of preferences of the panellists was gained from product S7 namely body scrub with the addition of brown seaweed S. polycystum as much as 7%. It is indicated that the brown seaweed S. polycystum possesses potentially body scrub raw material that is prospective in the cosmeceutical industry.

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Section: Phytochemical Resultsmentioning

confidence: 99%

The Potential Secondary Metabolites of Macroalgae Sargassum polycystum C. Agardh (1824) from the coast of West Aceh as Raw Material of Body Scrub

Gazali

Nurjanah²,

Husni³

et al. 2022

JFS

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show abstract

“…Aqueous extracts of Gracilaria corticata reported the highest amount of alkaloids compared with other seaweed extracts and alkaloids were absent in Ulva fasciata. Many reports revealed the presence of alkaloids in seaweeds and some of seaweed species have been investigated for their biological activities as well (Adikalaraj et al, 2011). Alkaloids are commonly found to have antimicrobial properties (Wangchuk et al, 2016) against both gram-positive and gram-negative bacteria (Lavanya and Veerappan, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…The results of the phytochemical investigation of seaweeds revealed the presence of various secondary metabolites in a varied degree. Recently, many studies have been conducted on the phytochemistry of seaweeds worldwide (Selvin and Lipton, 2004;Fayaz et al, 2005, Somepalli et al, 2007Adikalaraj et al, 2011). It suggests that seaweeds have a great medicinal value and have been extensively used in the pharmaceutical industry.…”

Section: Discussionmentioning

confidence: 99%

Preliminary screening of the aqueous extracts of twenty-three different seaweed species in Sri Lanka with in-vitro and in-vivo assays

Premarathna

Ranahewa

Wijesekera

et al. 2020

Heliyon

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Background: Seaweeds are an important source of bioactive compounds which are applied in various aspects of medicinal investigations. The present study was conducted to investigate cytoxicity (in-vitro and in-vivo) and wound healing activity of different seaweed species in Sri Lanka. Methods: Twenty-three seaweed samples, belonging to Phaeophyta (Brown), Chlorophyta (Green) and Rhodophyta (Red) were used for the experiments. Samples were collected from the inter-tidal and the sub-tidal habitats around Sri Lankan coast (Southern, Northern and North-western). Aqueous seaweed extracts were tested for cytotoxic and wound healing activity; in-vitro and in-vivo. To determine toxicity of aqueous seaweed extracts, brine shrimp lethality assay and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) colorimetric assay on mouse fibroblasts (L929) cell line were performed. Cell migration induction of seaweed extracts was assessed by scratch wound healing assay using L929 cell line. Based on the our previous experiments S.ilicifolium (SW23) was selected for the in vivo study to confirm our hypothesis. Albino mice (BALB/c) were divided into three groups (12 in each) and a circular area (44.07 AE 02.51 mm 2 ) of full skin was excised to create a wound in mice group II and III. Group III received aqueous extract of Sargasum illicifolium (400 mg/kg BW/day for 12 days, orally), Group II received distilled water for 12 days whereas Group I was used as the control group and it was tested without forming wounds and without providing any treatment. Further, the expression level of Tumor Necrosis Factor (TNF-α) and Transforming Growth Factor-β (TGF-β) via RT-PCR were measured every three days until the end of the experiment. Results: Phytochemical tests showed positive results to flavonoids in all the selected green seaweeds and alkaloids were observed in red seaweeds. In the toxicity assay, red seaweed, Acanthophora spicifera (SW17) was found to be highly effective on nauplii of brine shrimp (LC 50 ¼ 0.072 μg/μl). LC 50 value of green seaweed species, Caulerpa racemosa (SW02 and SW08) and Caulerpa sertularioides (SW10) was not found within the tested concentration series. The highest cytotoxic effect on L929 cell line was exhibited by aqueous extracts of red seaweed; Jania adhaereus with 50.70 AE 7.304% cell viability compared with control group. The highest cell migration activity was observed in L929 cell line group treated with extracts of green seaweed namely; Halimeda opuntin (SW07) and extracts of brown seaweed namely; Stoechospermum polypodioides (SW11). Extracts of S. illicifolium (SW23) exhibited a significantly enhanced wound healing activity in mice group III within three days (P < 0.05) with an open wound area of 17.35 AE 1.94 mm 2 compared with control group (26.29 AE 2.42 mm 2 ). TGF-β gene expression peaked on 6 th day of post-wound and subsequently decreased on 9 th day of post-wound in mice group III. TNF-α expression was suppressed in mice group III whereas it was elevated in group II. TGF-β expressi...

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Pharmacognostical and physicochemical evaluation of gandhakadi yoga vati: An ayurveda herbo-mineral formulation for thalassemia major

Chaudhary

Kori

Bhinde

et al. 2023

J Indian Sys Medicine

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Pharmacognostical and Phytochemical Evaluation of Gandhakadi Yoga

Cited by 3 publications

References 2 publications

The Potential Secondary Metabolites of Macroalgae Sargassum polycystum C. Agardh (1824) from the coast of West Aceh as Raw Material of Body Scrub

The Potential Secondary Metabolites of Macroalgae Sargassum polycystum C. Agardh (1824) from the coast of West Aceh as Raw Material of Body Scrub

Preliminary screening of the aqueous extracts of twenty-three different seaweed species in Sri Lanka with in-vitro and in-vivo assays

Pharmacognostical and physicochemical evaluation of gandhakadi yoga vati: An ayurveda herbo-mineral formulation for thalassemia major

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