Pharmacognostic Characterization of Enicostemma Littorale Blume

Rathod, Mayuri C; Dhale, D. A.

doi:10.7897/2277-4343.04624

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…Organic-inorganic hybrid complexes of titanium(IV) and their parent ligands have been screened for their growth inhibitory activity invitro against bacteria (E.Coli and P. Aeruginosa) and fungus (A.Flavus).Well diffusion method [25][26][27] was adopted to calculate the antimicrobial activity of titanium (IV) complexes and their corresponding ligands. Culture medium plates were sterilized.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Synergy Between DFT Calculations and Experimental Studies on the Optimized Structures and the Antibacterial Potential of Some Novel Tetra‐ and Penta Coordinated Organic‐ Inorganic Hybrid Complexes of Titanium(IV)

Sharma¹,

Kumar

Jain

et al. 2018

Applied Organom Chemis

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The generation, structure, reactivity and antibacterial potential of some tetraand penta coordinated organic-inorganic hybrid complexes of titanium(IV) were comprehensively studied experimentally and theoretically by using density functional theory (DFT). These complexes were generated by the reaction of titanium isopropoxide with sterically demanding oximes of heterocyclic βdiketones in 1:1 molar ratio in dry benzene. The chemical structures of titanium complexes were systematically modified using relatively sterically undemanding acetoxime as coligand. The reaction of the synthesized complexes TiL(OPr i ) 2 with the relatively undemanding acetoxime in 1:1 molar ratio in dry benzene afforded the complexes of the type TiLL'(OPr i ). Further reaction of the complexes TiLL'(OPr i ) with acetoxime in 1:1 molar ratio in dry benzene resulted in the formation of the complexes of the type TiL(L') 2 . Plausible structures of these newly generated organic-inorganic hybrid complexes of titanium(IV) were suggested on the basis of physico-chemical, spectral and mass studies. The optimized structures of the complexes TiLL'(OPr i ) andTiL(L') 2 were given by density functional theory (DFT/B3LYP method). DFT was used to investigate molecular orbitals, molecular electrostatic potential(MEP) and chemical reactivity of the complexes. Some of these complexs were screened against A.Flavus, P. Aeruginosa and E.Coli. These titanium(IV) complexes are potential candidates for use as antibacterial agents. The antibacterial activity of titanium(IV) complexes has been correlated with some of the principal quantum chemical descriptors.

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Section: Antimicrobial Activitymentioning

confidence: 99%

Synergy Between DFT Calculations and Experimental Studies on the Optimized Structures and the Antibacterial Potential of Some Novel Tetra‐ and Penta Coordinated Organic‐ Inorganic Hybrid Complexes of Titanium(IV)

Sharma¹,

Kumar

Jain

et al. 2018

Applied Organom Chemis

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“…[7] The common name of EL, is Chota-kirayata or Chota chirayata (Hindi), and Mamejavo (Gujarati), is being used as a medicinal herb for the treatment of diabetes mellitus. [8][9] It is a well-known plant used as a drug in Ayurveda, Unani, Siddha, Allopathic, Homeopathy, Naturopathy and Home Remedies, [10] and it is widely used in Siddha system of medicine under the name "Vellarugu" [11][12][13] for the treatment of diabetes mellitus, arthritis, rheumatism, constipation, abdominal ulcers, hernia, swelling, fever, skin diseases and insect poisoning. [14][15][16] The plant AH is used to cure diseases such as hysteria, throat infection, dyspepsia, abdominal pain, diabetes, diarrhea, etc.…”

Section: Introductionmentioning

confidence: 99%

Formulation, Phytochemical Estimation of Active principles by Spectroscopic methods and Comparison of the Poly Herbal Antidiabetic Tablet with the Commercial Tablets

Chauhan,

Mistry,

Vasava

et al. 2020

IJPSDR

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Diabetes mellitus is a group of metabolic disorders characterized by increased glucose levels over a prolonged period. The poly-herbal anti-diabetic tablet was formulated in the laboratory by using herbs of Enicostemma littorale (EL) (Gentianaceae), roots of Aconitum heterophyllum (AH) (Ranunculaceae), rhizomes of Picrorhiza kurroa (PK) (Scrophulariaceae), and fruits of Piper longum (PL) (Piperaceae). Furthermore, Laboratory formulation (LF) and Marketed formulations (MFs) were tested for Phytochemical screening and Qualitative chemical examination. From their result, isolation of active principles, Swertiamarin (EL-1) and Piperine (PN-1), was done and subjected to phytochemical examination by Modern analytical methods like TLC, UV, FTIR. Finally, the quantification and estimation of the aforementioned compounds were achieved by HPTLC. SSE of all the four formulations and the chemical tests proved alkaloids, flavonoids, carbohydrates, tannins, phenols and phytosterols. Comparing the data frommthe melting point, TLC, UV, and IR studies of EL-1 and PN-1 with standard Biomarkers, further calculation of both markers concentrations was done with the help of the calibration equation and the peak area derived from the chromatogram. Study outcomes signify that LF was more potent than MFs for anti-diabetic activity, signifying as a promising natural and safe remedy for the prevention of diabetic complications.

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Investigation of phytoconstituents of Enicostemma littorale as potential glucokinase activators through molecular docking for the treatment of type 2 diabetes mellitus

Khan¹,

Unnisa

Sohel³

et al. 2021

In Silico Pharmacol.

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Pharmacognostic Characterization of Enicostemma Littorale Blume

Cited by 4 publications

References 9 publications

Synergy Between DFT Calculations and Experimental Studies on the Optimized Structures and the Antibacterial Potential of Some Novel Tetra‐ and Penta Coordinated Organic‐ Inorganic Hybrid Complexes of Titanium(IV)

Synergy Between DFT Calculations and Experimental Studies on the Optimized Structures and the Antibacterial Potential of Some Novel Tetra‐ and Penta Coordinated Organic‐ Inorganic Hybrid Complexes of Titanium(IV)

Formulation, Phytochemical Estimation of Active principles by Spectroscopic methods and Comparison of the Poly Herbal Antidiabetic Tablet with the Commercial Tablets

Investigation of phytoconstituents of Enicostemma littorale as potential glucokinase activators through molecular docking for the treatment of type 2 diabetes mellitus

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