Pharmacogenomics Testing in a Community Pharmacy: Patient Perceptions and Willingness-to-pay

Gibson, Mara L.; Hohmeier, Kenneth C.; Smith, Cindy Taliaferro

doi:10.2217/pgs-2016-0161

Cited by 38 publications

(44 citation statements)

References 19 publications

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“…Although various models of PGx testing services exist, limited information is available regarding how patients utilize and view the value of their clinical results postdisclosure. A number of studies assessed attitudes toward PGx testing in a variety of clinical and research populations, specifically in participants who had not undergone PGx testing [18][19][20][21][22][23][24][25]. Many of these studies reported that the majority of individuals queried are interested in PGx testing and that participants see value in PGx testing for its potential to provide insight into risk of side effects or to tailor medication prescribing [19][20][21][22].…”

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confidence: 99%

“…Many of these studies reported that the majority of individuals queried are interested in PGx testing and that participants see value in PGx testing for its potential to provide insight into risk of side effects or to tailor medication prescribing [19][20][21][22]. However, several areas of patient concern were revealed, including cost; privacy of genetic information; and potential psychological consequences about ancillary risk information [18,19,[22][23][24][25][26].…”

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confidence: 99%

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Patient Perspectives Following Pharmacogenomics Results Disclosure in an Integrated Health System

et al. 2018

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Patient Perspectives Following Pharmacogenomics Results Disclosure in an Integrated Health System

et al. 2018

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“…However, patients may not want to be involved with pharmacogenomic testing as they may not necessarily connect the benefits of testing to their health [40] . Patients have shown an interest, but willingness to pay for a service varies [40] .…”

Section: Benefits Of Pharmacogenomic Testingmentioning

confidence: 99%

Pharmacogenomic testing and its future in community pharmacy

2020

Pharmaceutical Journal

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Although it is common to see pharmacogenomic testing used North America and Australia, it is not yet part of practice in the UK. With the promise of genomic screening becoming part of the NHS, pharmacists must equip themselves with a knowledge of how the process works. Source: Shutterstock.com In January 2019, the UK government unveiled its ten-year plan for NHS England and emphasised the role pharmacists can play in promoting patient self-care [1]. There was also a focus on delivering value from medicines and reducing avoidable medicines related-harm, which costs the NHS a minimum of £98.5m per year [2]. This coincides with the NHS Genomic Medicine Service, which will be rolled out across England from April 2020, meaning that the routine use of genomic screening and personalised treatments will be the new normal in the NHS [3],[4]. Pharmacists' advice currently relies on knowledge of observable patient characteristics, such as age, weight, comorbidities and concurrent medicines, while largely disregarding genetics. However, it is estimated that genetic factors could contribute to between 25-50% of inappropriate drug responses [5]. Knowing exactly which medicine to use for a patient and which to avoid can be a challenging task in clinical practice. However, pharmacogenomics can provide the prescriber with additional information on some of the unobserved patient characteristics that affect drug responsethis can assist with both drug selection and safety. Therefore, the combination of this pharmacogenomic information along with other factors influencing pharmaceutical care may provide an opportunity to deliver more 'personalised' medicine, facilitating better selection and reducing the need for 'trial and error' prescribing.

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“…This failure has been empirically demonstrated to reduce patients’ willingness to utilize PGT, irrespective of their interest in such tests. 11 Fortunately, the Veterans’ Affairs Medical System through which PT was treated has the wisdom to recognize that cost containment is not necessarily synonymous with cost efficiency.…”

Section: Folate Supplementationmentioning

confidence: 99%

Pharmacogenetic guidance: individualized medicine promotes enhanced pain outcomes

Dragic

Wegrzyn

Schatman

et al. 2017

JPR

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The use of pharmacogenomics has become more prevalent over the past several years in treating many disease states. Several cytochrome P450 enzymes play a role in the metabolism of many pain medications including opioids and antidepressants. Noncytochrome P450 enzymes such as methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) also play a role in the explanation of opioid dosage requirements as well as in response to certain antidepressants. We present the case of a patient with reduced COMT and MTHFR expression treated with leucovorin 10 mg daily for the management of chronic pain. The use of leucovorin in this patient decreased pain scores, which were clinically significant and increased functionality. This case demonstrates the importance of pharmacogenetics testing in patients, as this can help direct providers to better therapeutic options for their patients.

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Pharmacogenomics Testing in a Community Pharmacy: Patient Perceptions and Willingness-to-pay

Cited by 38 publications

References 19 publications

Patient Perspectives Following Pharmacogenomics Results Disclosure in an Integrated Health System

Patient Perspectives Following Pharmacogenomics Results Disclosure in an Integrated Health System

Pharmacogenomic testing and its future in community pharmacy

Pharmacogenetic guidance: individualized medicine promotes enhanced pain outcomes

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