Pharmacogenomics of infliximab treatment using peripheral blood cells of patients with rheumatoid arthritis

Molecular and cellular heterogeneity in the Rheumatoid Arthritis synovium: Clinical correlates of synovitis

“…These data suggest either incomplete blockade of TNFa signaling in non-responders, potentially through an inadequate pharmacodynamic response, or alternatively therapeutic resistance mediated through activation of TNF-independent pathways. The latter is more plausible given gene expression studies in peripheral blood of RA patients that demonstrated equivalent changes in gene expression after TNFa therapy regardless of clinical outcome [62]. Some evidence exists for an opposing effect of synovial lymphoid aggregates, since a large histological study of 86 RA patients showed that patients who had high levels of synovial lymphoid neogenesis, comprising highly organized B and T cell aggregates, had poorer clinical outcomes to anti-TNFa therapy, whilst reversal of these aggregates was associated with good response [63].…”

Developing Peripheral Blood Gene Expression-Based Diagnostic Tests for Coronary Artery Disease: a Review

“…Disease definitions varied between studies, as did patient populations. Different exclusions were applied to patients with a previous history of MI or CAD, as well as other conditions whose presence might confound CAD signals; diabetes and rheumatoid arthritis have each been shown to influence the expression of genes associated with CAD [18,19] as has the use of steroids or immunosuppressive drugs [20][21][22][23]. A variety of gene expression profiling technologies exist (summarized in Table 2) including multiple microarray platforms, which differed between the above studies.…”

Upcoming value of gene expression analysis in rheumatology

“…IFN 1 типа могут влиять на инициацию или амплификацию аутоиммунитета и повреждение тканей [1]. Кроме того, исследования in vitro показали, что TNFa и IFN 1 типа могут взаимно подавлять действие друг друга [16].…”