Pharmacoenvironmentology – a component of pharmacovigilance

Rahman, Syed Ziaur; Khan, Rahat; Gupta, Varun; Uddin, Misbah

doi:10.1186/1476-069x-6-20

Cited by 28 publications

(18 citation statements)

References 17 publications

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“…To assess the interaction of the human body with pharmaceuticals, we need to understand the complex relationship between ecology, physiology, and pharmacology ( Rahman et al, 2007 ; Flintoft, 2012 ; Haiser and Turnbaugh, 2012 ). From pharmacogenomic studies it is clear that sequence variations in drug target proteins, drug-metabolizing enzymes, and drug transporters can alter drug efficacy, produce side effects, causing variable drug responses in individual patients ( Wilson and Nicholson, 2009 ).…”

Section: Microbiota-based Pharmaceuticalsmentioning

confidence: 99%

Human microbiomes and their roles in dysbiosis, common diseases, and novel therapeutic approaches

2015

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The human body is the residence of a large number of commensal (non-pathogenic) and pathogenic microbial species that have co-evolved with the human genome, adaptive immune system, and diet. With recent advances in DNA-based technologies, we initiated the exploration of bacterial gene functions and their role in human health. The main goal of the human microbiome project is to characterize the abundance, diversity and functionality of the genes present in all microorganisms that permanently live in different sites of the human body. The gut microbiota expresses over 3.3 million bacterial genes, while the human genome expresses only 20 thousand genes. Microbe gene-products exert pivotal functions via the regulation of food digestion and immune system development. Studies are confirming that manipulation of non-pathogenic bacterial strains in the host can stimulate the recovery of the immune response to pathogenic bacteria causing diseases. Different approaches, including the use of nutraceutics (prebiotics and probiotics) as well as phages engineered with CRISPR/Cas systems and quorum sensing systems have been developed as new therapies for controlling dysbiosis (alterations in microbial community) and common diseases (e.g., diabetes and obesity). The designing and production of pharmaceuticals based on our own body’s microbiome is an emerging field and is rapidly growing to be fully explored in the near future. This review provides an outlook on recent findings on the human microbiomes, their impact on health and diseases, and on the development of targeted therapies.

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Section: Microbiota-based Pharmaceuticalsmentioning

confidence: 99%

Human microbiomes and their roles in dysbiosis, common diseases, and novel therapeutic approaches

2015

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“…Gandhi Kundri Shrub Leaves Epilepsy, mental disorder NRE [ 89 ] Trichosanthes bracteata (Lam.) Voigt Makalphal Climber Fruit, seed Headache NRE [ 97 ] Trichosanthes cucumerina L. Chichinga Climber Fruit, seed Headache NRE [ 129 ] Cyperaceae Cyperus rotundus L. Mutha, Takudare (Sa) Graminoid Root Paralysis, (Sa) Modulate memory impairment [ 175 , 176 ] Dilleniaceae Dillenia indica L. Chalta Tree Fruit Epilepsy, headache Inhibit diabetic neuropathic pain [ 114 , 177 , 178 ] Dioscoreaceae Dioscorea bulbifera L. Banalu Climber Aerial part, tuber Headache NRE [ 101 ] Dioscorea pentaphylla L. Thubri Vine Leaves Paralysis NRE [ 114 ...…”

Section: Introductionmentioning

confidence: 99%

“… Alpani Shrub Leaves, root Mental disorder CNS depressant [ 101 ] Desmodium triquetrum DC. Komorsina Undershrub Root Epilepsy, paralysis (Ch) NRE [ 89 , 129 , 184 ] Mucuna pruriens DC. Alkushi Climber Root, seed Nervine tonic Neuroprotection for Parkinson's disease [ 101 , 185 ] Saraca indica L. Ashok Tree Leaves, bark Nervous debility Antidepressant [ 186 , 187 ] Lamiaceae Callicarpa arborea Roxb.…”

Section: Introductionmentioning

confidence: 99%

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

Uddin

Zidorn

2020

Nat. Prod. Bioprospect.

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The majority of the population in Bangladesh uses traditional plant-based medicines to manage various ailments, including central nervous system (CNS) disorders. This review presents ethnobotanical information and relevant scientific studies on plants used in traditional healthcare for the management of various CNS disorders in Bangladesh. The information on the medicinal plants of Bangladesh effective against CNS disorders published in scientific journals, books, and reports was compiled from different electronic databases using specific key words. The present article provides comprehensive information on a total of 224 medicinal plant species belonging to 81 families used for the treatment of CNS disorders by the various peoples of Bangladesh. In total, we reviewed more than 290 relevant papers. In this study, leaves were found as the most often used plant organ, followed by roots, fruits, whole plants, barks, seeds, stems, rhizomes, and flowers. The Fabaceae family contributes the highest number of used species, followed by Rubiaceae, Lamiaceae, Cucurbitaceae, Vitaceae, Euphorbiaceae, Malvaceae, and Zingiberaceae. The most frequently used species (in decreasing order) are Asparagus racemosus, Centella asiatica, Stephania japonica, Aegle marmelos, Coccinia grandis, Tabernaemontana divaricata, Bacopa monnieri, Abroma augusta, and Scoparia dulcis. This review may serve as a starting point for a rational search for neuroactive natural products against CNS disorders within the Flora of Bangladesh. Graphic Abstract

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“…Consequently, this system is used in the identification of signals of new, rare and serious ADRs of drugs. This system makes it easier for physicians, patients and pharmacists to report suspected ADRs to the pharmacovigilance centre (Herdiero et al 2005 ; Olsson 2008 ; Rahman et al 2007 ). The pharmacovigilance centre collects all these reports and informs the stakeholders about the new reported ADRs.…”

Section: Roles Of Pharmacovigilance In Monitoring Adrsmentioning

confidence: 99%

Adverse drug reactions monitoring: prospects and impending challenges for pharmacovigilance

Sahu¹,

Yadav²,

Prasad³

et al. 2014

SpringerPlus

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Pharmacovigilance plays a consequential role in the surveillance of adverse drug reactions, which is provoked by the drugs used to cure diseases. Adverse drug reactions (ADRs) produce detrimental or undesirable effects to the body after administration of drugs. It has been reported that the number of patients dying because of contrary effects of drugs per year increased upto 2.6-fold. Moreover, rates of hospitalization of patients are increasing owing to adverse effects of drugs. Thus, it becomes challengeable for physician, health care providers, WHO and pharmaceutical industries to resolve the associated problem of ADRs. During the clinical trial of a novel drug, it is prominent to explore the dependability of drug. In this review, we documented the details required to identify the ADRs in patients along with reported banned drugs.

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Pharmacoenvironmentology – a component of pharmacovigilance

Cited by 28 publications

References 17 publications

Human microbiomes and their roles in dysbiosis, common diseases, and novel therapeutic approaches

Human microbiomes and their roles in dysbiosis, common diseases, and novel therapeutic approaches

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

Adverse drug reactions monitoring: prospects and impending challenges for pharmacovigilance

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