Pharmacodynamic Effects of Very High Dilutions of Belladonna on the Isolated Rat Duodenum

We identified 24 experimental models in basic research on high homeopathic potencies, which were repeatedly investigated. 22 models were reproduced with comparable results, 6 models with different results, and repetition showed no results for 15 models. Independent reproductions with either comparable or different results were found for seven models. We encourage further repetition trials of published studies, in order to learn more about the model systems used and in order to test their repeatability.

Section: Initial Studiesmentioning

confidence: 77%

Section: Initial Studiesmentioning

confidence: 99%

Repetitions of fundamental research models for homeopathically prepared dilutions beyond 10-23: a bibliometric study

Endler¹,

Thieves²,

Reich³

et al. 2010

“…Other in vitro and isolated organ studies reveal the same oscillatory pattern of potency/effect curve. 17,[86][87][88][89] The possibility of considering this kind of behavior as a possible marker of high dilution phenomenon is discussed. 46 In short, mathematical modeling can be useful to establish precise conceptual parameters, maybe, a sine qua non condition to build solid hypothesis about mechanisms.…”

Section: Conceptual Aspectsmentioning

confidence: 99%

Animal models for studying homeopathy and high dilutions: Conceptual critical review

Bonamin¹,

Endler²

2010

Systematic analysis of the selected papers yielded evidence of some important intrinsic features of high dilution studies performed in animal models: a) methodological quality was generally adequate, some aspects could be improved; b) convergence between results and materia medica is seen in some studies, pointing toward to the possibility of systematic study of the Similia principle c) both isopathic and Similia models seem useful to understand some complex biological phenomena, such as parasite-host interactions; d) the effects of high dilutions seem to stimulate restoration of a 'stable state', as seen in several experimental models from both descriptive and mathematical points of view.

“…This simple model has the potential to remove doubts about the activity of very highly diluted homeopathic medicines. [66][67][68][69][70][71][72][73][74] Many of these experiments are well conducted, in controlled conditions, with sufficient numbers and with correct statistical analysis. The facts are indisputable, statistically significant and reproducible, even if they cannot be explained by the molecular paradigm.…”

Section: Introductionmentioning

confidence: 99%

Priorities and methods for developing the evidence profile of homeopathy Recommendations of the ECH General Assembly and XVIII Symposium of GIRI

Wassenhoven¹

2005

To achieve scientific acceptance, homeopathy must investigate several questions: 1. The activity of very highly diluted preparations. The consensus of the meeting was that there is clear evidence of this. 2. The content of very highly diluted homeopathic preparations. More research is needed but evidence exists that a specific signal is present in homeopathic preparations. 3. A theoretical framework in which the effects of homeopathic diluted preparations can be explained. The 'Body Information Theory' is such a theory. 4. The clinical effectiveness of homeopathy. Because they avoid the placebo effect, animal studies are a priority. For human trials using Quality of Life questionnaires, studies on the activity, content and theoretical basis of homeopathic preparations were reviewed approximately 70% of cases; more in children showed improvement. Homeopathy reduced costs and allowed a better improvement in work-days lost compared with conventional practice. Randomised controlled trials (RCTs) implicitly test the placebo hypothesis; RCTs have been performed and meta-analyses conclude that there is clear evidence of efficacy which cannot be attributed to placebo effect. Priorities depend on the audience. More research is needed especially regarding the content of homeopathic preparations and the transmission of information. Theoretical issues are also important to avoid incorrect design of research protocols. More effort should be dedicated to veterinary research. Clinical effects analysis in humans remains important. Many other questions should be prioritised, such as the potential of homeopathy to avoid invasive procedures in children and the long-term effects of homeopathy in preventing chronic complications.