Pharmacist initiation of postexposure doxycycline for Lyme disease prophylaxis

Jackson, Anita N.; Orr, Kelly; Bratberg, Jeffrey; Silverblatt, Fredric J.

doi:10.1331/japha.2014.13106

Cited by 8 publications

(5 citation statements)

References 15 publications

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“… 38 , 39 Expanding pharmacist services further under a collaborative practice agreement allowed pharmacists to screen patients and dispense prophylactic doxycycline, which resulted in no patients developing Lyme disease and patients being highly satisfied with the pharmacist’s interaction. 40 Pharmacist involvement in transitions of care is also occurring in community pharmacies as a way to improve care and reduce hospital readmissions, but the results have been mixed. One study found pharmacists providing medication reconciliation and counseling for polypharmacy patients upon hospital discharge as part of a multifaceted longitudinal intervention was found to reduce medication costs, but did not impact mortality, but patients who received medication counseling from community pharmacists were more satisfied with the counseling.…”

Section: Types Of Servicesmentioning

confidence: 99%

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Review of community pharmacy services: what is being performed, and where are the opportunities for improvement?

Melton¹,

Lai²

2017

IPRP

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ObjectiveThe aim of this review was to assess pharmacist and pharmacy services being provided and identify opportunities to improve patient satisfaction.MethodsStudies published between January 2006 and July 2016 examining patient satisfaction with pharmacy and pharmacist services, which were written in English, were identified in PubMed. Studies were excluded if they only looked at pharmacy student-provided services.Key findingsA total of 50 studies were ultimately included in the review. Of these studies, 28 examined services traditionally provided by community pharmacists such as dispensing and counseling, while 16 examined a new in-person service being offered by a pharmacy, and the remaining six involved a new technology-assisted service. While study findings were generally positive for patient satisfaction of pharmacy services, several opportunities were identified for pharmacies to improve.ConclusionOverall, patient satisfaction is high across pharmacy services; however, this satisfaction is related to prior patient exposure to services and their level of expectation. Pharmacists have multiple opportunities to improve the services they provide, and there are additional services pharmacists may consider offering to expand their role within the health care system.

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Section: Types Of Servicesmentioning

confidence: 99%

“… 4 , 24 Collaborative practice agreements can improve access for patients in rural areas, but care must be taken to select programs, which will benefit a significant number of patients. 40 …”

Section: Opportunities For Improvementmentioning

confidence: 99%

Review of community pharmacy services: what is being performed, and where are the opportunities for improvement?

Melton¹,

Lai²

2017

IPRP

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“…Korenberg et al [24] reported that none of the patients in the experimental group (n = 261) developed erythema migrans after receiving doxycycline (100 mg twice daily) for 3-5 days after the tick bite, whereas 5/97 patients developed erythema migrans in the control group which did not receive any antibiotics. Jackson et al [25] reported the clinical Risk Ratio MH, Random, 95% CI Fig. 2 Forest plot of the risk ratio for incidence rates of Lyme disease, with antibiotic groups versus control groups application of doxycycline for Lyme disease prophylaxis, and the results indicated a high level of satisfaction with the pharmacy services provided, with no reports of subsequent development of Lyme disease symptoms or other side effects.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic prophylaxis for prevention against Lyme disease following tick bite: an updated systematic review and meta-analysis

Zhou

Peng

et al. 2021

BMC Infect Dis

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Background In areas where Lyme disease is endemic, bites from ticks are common, but no vaccine is currently available against Lyme disease for humans. Therefore, the feasibility of using antibiotic prophylaxis to prevent Lyme disease after a tick bite is worth further exploration. Previous meta-analyses lack sufficient power to demonstrate the efficacy of about antibiotic prophylaxis for the prevention of Lyme disease following a tick bite. In this study, we explored more precise evidence and attempted to identify and update optimum treatment strategies. Methods We searched PubMed, Embase, and the Cochrane Library for studies until March 23, 2021. We included studies if the enrolled patients were randomly allocated to a treatment or control group within 72 h following a tick bite and had no clinical evidence of Lyme disease at enrolment. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guidelines were followed for data abstraction. Two authors (GZZ and XX) independently reviewed the abstracts and identified articles for detailed assessment. We used a random-effects model to calculate the pooled results and reported the 95% confidence interval (CI). Study quality was assessed using a modified Jadad scale, and publication bias was assessed using Egger’s test. We calculated the risk ratio (RR) for the rates of unfavorable events in patients who received intervention versus the control group. This study is registered with PROSPERO, number CRD42021245002. Results Six studies (3,766 individuals) were included. The pooled rate of unfavorable events in persons receiving treatment and the control group were 0.4% (95%CI: 0.1–1.1%) and 2.2% (95%CI: 1.6–3.0%), respectively. The pooled RR was 0.38 (95%CI: 0.22–0.66). Subgroup analysis revealed that the pooled RR was 0.29 (95%CI: 0.14–0.60) in the single-use 200-mg doxycycline group; 0.28 (95%CI: 0.05–1.67) in a 10-day course group (Amoxicillin, Penicillin or tetracycline); and 0.73 (95%CI: 0.25–2.08) in a topical antibiotic treatment group (Azithromycin). Conclusions The available evidence supports the use of antibiotics for the prevention of Lyme disease, and reveals advantages of using single-dose; however, further confirmation is needed.

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“…Korenberg et al [24] reported that none of the patients in the experimental group (n = 261) developed erythema migrans after receiving doxycycline (100 mg twice daily) for 3-5 days after the tick bite, whereas 5/97 patients developed erythema migrans in the control group which did not receive any antibiotics. Jackson et al [25] reported the clinical application of doxycycline for Lyme disease prophylaxis, and the results indicated a high level of satisfaction with the pharmacy services provided, with no reports of subsequent development of Lyme disease symptoms or other side effects. However, the sample size of this study was small (n = 8).…”

Section: Discussionmentioning

confidence: 99%

Antibiotic Prophylaxis for Prevention against Lyme Disease Following Tick Bite: An Updated Systematic Review and Meta-Analysis

Zhou

Yue

et al. 2021

Preprint

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Background: In areas where Lyme disease is endemic, bites from ticks are common, but no vaccine is currently available against Lyme disease for humans. Therefore, the feasibility of using antibiotic prophylaxis to prevent Lyme disease after a tick bite is worth further exploration. Previous meta-analyses lack sufficient power to demonstrate the efficacy of about antibiotic prophylaxis for the prevention of Lyme disease following a tick bite. In this study, we explored more precise evidence and attempted to identify and update optimum treatment strategies.Methods: We searched PubMed, Embase, and the Cochrane Library for studies until March 23, 2021. We included studies if the enrolled patients were randomly allocated to a treatment or control group within 72 h following a tick bite and had no clinical evidence of Lyme disease at enrolment. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guidelines were followed for data abstraction. Two authors (GZZ and XX) independently reviewed the abstracts and identified articles for detailed assessment. We used a random-effects model to calculate the pooled results and reported the 95% confidence interval (CI). Study quality was assessed using a modified Jadad scale, and publication bias was assessed using Egger’s test.We calculated the risk ratio (RR) for the rates of unfavorable events in patients who received intervention versus the control group. This study is registered with PROSPERO, number CRD42021245002Results: Six studies (3,766 individuals) were included. The pooled rate of unfavorable events in persons receiving treatment and the control group were 0.4% (95%CI: 0.1–1.1%) and 2.2% (95%CI: 1.6–3.0%), respectively. The pooled RR was 0.38 (95%CI: 0.22–0.66). Subgroup analysis revealed that the pooled RR was 0.29 (95%CI: 0.14–0.60) in the single-use 200-mg doxycycline group; 0.28 (95%CI: 0.05–1.67) in a 10-day course group (Amoxicillin, Penicillin or tetracycline); and 0.73 (95%CI: 0.25–2.08) in a topical antibiotic treatment group (Azithromycin).Conclusions: The available evidence supports the use of antibiotics for the prevention of Lyme disease, and reveals advantages of using single-dose; however, further confirmation is needed.

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Pharmacist initiation of postexposure doxycycline for Lyme disease prophylaxis

Cited by 8 publications

References 15 publications

Review of community pharmacy services: what is being performed, and where are the opportunities for improvement?

Review of community pharmacy services: what is being performed, and where are the opportunities for improvement?

Antibiotic prophylaxis for prevention against Lyme disease following tick bite: an updated systematic review and meta-analysis

Antibiotic Prophylaxis for Prevention against Lyme Disease Following Tick Bite: An Updated Systematic Review and Meta-Analysis

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