Antibiotic prophylaxis for prevention against Lyme disease following tick bite: an updated systematic review and meta-analysis

Zhou, Guozhong; Xu, Xin; Peng, Yue; Luo, Shiqi; Fan, Yuxin; Chen, Jingjing; Liu, Meixiao; Dong, Yan; Li, Bingxue; Kong, Jing; Wen, Shiyuan; Liu, Aihua; Bao, Fukai

doi:10.1186/s12879-021-06837-7

Cited by 9 publications

(8 citation statements)

References 30 publications

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“…Because preventing one case of Lyme disease would require prophylactically treating 50 patients who had a tick bite, prophylactic treatment should not be used in all patients and should strictly adhere to the five criteria mentioned. By following these guidelines, clinicians should be able to identify patients at highest risk for developing Lyme disease and complications from undiagnosed Lyme disease 24. Prophylaxis is recommended for patients who meet the above five criteria because the benefits of prophylaxis likely outweigh the risks.…”

Section: Prophylactic Treatment and Vaccinationmentioning

confidence: 99%

“…• No contraindication to doxycycline • The attached tick is identifi ed as an I. scapularis tick • The tick has been estimated to be attached for more than 36 hours • Prophylaxis is initiated within 72 hours of tick removal • The exposure occurred in a highly endemic area. 24 Because preventing one case of Lyme disease would require prophylactically treating 50 patients who had a tick bite, prophylactic treatment should not be used in all patients and should strictly adhere to the fi ve criteria mentioned. By following these guidelines, clinicians should be able to identify patients at highest risk for developing Lyme disease and complications from undiagnosed Lyme disease.…”

Section: Prophylactic Treatment and Vaccinationmentioning

confidence: 99%

“…By following these guidelines, clinicians should be able to identify patients at highest risk for developing Lyme disease and complications from undiagnosed Lyme disease. 24 Prophylaxis is recommended for patients who meet the above fi ve criteria because the benefits of prophylaxis likely outweigh the risks. Adults should be treated with a single dose of doxycycline 200 mg, and children weighing less than 45 kg (99.2 lb) should receive 4.4 mg/kg in a single dose.…”

Section: Prophylactic Treatment and Vaccinationmentioning

confidence: 99%

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Early identification of Lyme disease complications

Eckenrode¹

2023

Jaapa

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migrans rash, which is often described as a localized annular lesion with central clearing (Figure 1). 6 During early disseminated disease, the patient may experience a constellation of symptoms including fever, headaches, fatigue, myalgia, facial nerve palsies, and cardiac or neurologic complications (Table 1). 1,5 If left untreated, Lyme disease can lead to a variety of different complications including Lyme arthritis, Lyme carditis, and Lyme neuroborreliosis. Up to 60% of patients with untreated early Lyme disease will develop Lyme arthritis. 5 Lyme arthritis typically is manifested during late disease and can occur weeks or even months after the initial tick bite. 5 Between 4% and 10% of patients with untreated Lyme disease will develop Lyme carditis, which is most commonly seen in patients ages 10 to 45 years. 1,4 Lyme neuroborreliosis is less common in the United States than in Europe, and about 11% of patients with Lyme infection present with neurologic symptoms. 7 LYME ARTHRITISLyme arthritis is the most common complication of late Lyme disease and often presents as monoarthritis of the knee weeks or months after the initial tick bite. 5 It also can present as asymmetric oligoarthritis, most often of the large joints (Table 2). Lyme arthritis is caused by vascular damage, cytotoxic processes, proliferation of fi broblasts, and fi brosis in the joint in response to a proinfl ammatory © DAVID JARA BOGUNYA/SHUTTERSTOCK.COM I n the United States, Lyme disease, a tick-borne illness, is most commonly caused by the spirochete bacteria Borrelia burgdorferi. 1 Although about 30,000 cases are reported each year in the United States, the actual incidence of Lyme disease is about 476,000 cases annually, with most cases occurring in the Northeast and upper Midwest. 2 A missed diagnosis of Lyme disease can lead to a variety of systemic complications and increase patient morbidity and mortality.The incubation period of Lyme disease ranges from 3 to 30 days, with an average of 7 to 14 days. 3 Lyme disease is more common in males and typically follows a bimodal age distribution, occurring most commonly in children ages 5 to 9 years and adults ages 45 to 59 years. 4 The three stages of Lyme disease are early localized, early disseminated, and late disease. 5 In early localized disease, about 80% of patients will experience the classic erythema ABSTRACT Complications of Lyme disease including Lyme arthritis, Lyme carditis, and Lyme neuroborreliosis, typically occur during the early disseminated and late phases of the disease. Clinicians must maintain a high index of suspicion so they can recognize and treat complications promptly. Early treatment with appropriate antibiotics often leads to improved clinical outcomes.

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Section: Prophylactic Treatment and Vaccinationmentioning

confidence: 99%

Section: Prophylactic Treatment and Vaccinationmentioning

confidence: 99%

Section: Prophylactic Treatment and Vaccinationmentioning

confidence: 99%

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Early identification of Lyme disease complications

Eckenrode¹

2023

Jaapa

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“…Some are also used to treat malaria, Lyme disease, tuberculosis, Rocky Mountain spotted fever and leprosy. [10][11][12] Most antibiotics in the aquatic environment are caused by the direct use of drugs in aquaculture. Traditional sewage treatment methods still result in some residues in the water environment, which have not been fully absorbed and removed.…”

Section: Introductionmentioning

confidence: 99%

Photocatalytic Degradation of Tetracycline Hydrochloride by Zinc oxide/Polypyrrole/Carbon nanotubes

Gong

Ren

et al. 2023

ChemistrySelect

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In this study, the intermediates of the photocatalytic degradation of tetracycline hydrochloride (TC‐HCl) were analyzed by high performance liquid chromatography‐mass spectrometry. The doping of polypyrrole (PPy) and carbon nanotubes (CNTs) increased the reaction rate of TC‐HCl degradation by ZnO. The prepared ZnO has a large specific surface area, which can improve the adsorption performance. The introduction of PPy and CNTs can promote electron transfer and reduce the recombination of photogenerated electron hole pairs in the composite material ZnO/PPy/CNTs(ZPC), and the photocatalytic performance of the composite sample is improved. In addition, the new visible light catalyst has strong degradation effect on TC‐HCl. Using tetracycline hydrochloride as a pollutant, the photocatalytic degradation performance of each sample was analyzed. After 240 min of photoreaction, the Degradation rate of TC‐HCl (DTC‐HCl) by ZnO was 24.1 %, while that by ZPC was 91.5 %. Meanwhile, the intermediates of photocatalytic degradation of TC‐HCl were analyzed by high performance liquid chromatography‐mass spectrometry. The peak intensity of TC‐HCl from adsorption equilibrium to the end of the photocatalytic reaction occurred at a retention time of about 10.05 min and decreased with the increase of the reaction time. This indicates that TC‐HCl is broken down into small molecules during the reaction. Through the analysis of intermediates and active species, the degradation pathway of tetracycline hydrochloride was deduced.

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“…Prophylaxis against systemic tick infections may be considered within 72 hours of exposure, especially if the exposure occurred in a high-risk or endemic region. 4,5 Routine antibiotic prophylaxis may include oral doxycycline. At present, there has been no reported case of Lyme disease in Singapore.…”

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confidence: 99%