Pharmaceuticals for binary radiotherapy

Antitumor efficacy of extracellular complexes with gadolinium in Binary Radiotherapy

“…Thereby existing drugs already approved for clinical use, such as MRI and X-ray contrast drugs, could be used for treating certain types of tumor with Binary Radiotherapy. Also, new non-toxic inert BRT-drugs with no physiological activity could be developed and approved for clinical use in Binary Radiotherapy (Kulakov et al, 2013). Gold and gadolinium nanoparticles probably can be used for that purpose.…”

“…Binary Radiotherapy is a developing method of radiotherapy which uses special pharmaceuticals (let us call them BRT-drugs) to form absorbed dose field of desirable shape (Kulakov et al, 2013). Formation of absorbed dose field is caused by preferential interaction of external radiation with specific element (absorbing element) contained in a BRT-drug (Sheino, 2006).…”

Сравнение Противоопухолевой Эффективности Висмута И Гадолиния Как Дозоповышающих Агентов В Препаратах Для Фотон-Захватной Терапии

“…A. A. Lipengol'ts 1,2,3 , A. A. Cherepanov 1 Antitumor efficacy of the photon capture therapy (or contrast enhanced radiotherapy, CERT) in high extent depends on the properties of particular drug containing a high-Z chemical element with high capability of absorbing external x-rays.…”

“…Ýòî óäàåòñÿ ðåàëèçîâàòü â áèíàðíûõ òåõíîëîãèÿõ, îäíîé èç êîòîðûõ ÿâëÿåòñÿ ôîòîí-çàõâàòíàÿ òåðàïèÿ (ÔÇÒ). Òåðàïåâòè÷åñêàÿ ýôôåêòèâíîñòü òåõíîëîãèè ÔÇÒ çàêëþ÷àåòñÿ â ñîçäàíèè òóìîðîöèäíîé äîçû â îáëó÷àåìîé ìèøåíè çà ñ÷åò ïðåèìóùåñòâåííîãî âçàèìîäåéñòâèÿ âíåøíåãî èîíèçèðóþùåãî èçëó÷åíèÿ ñ äîçîïîâûøàþùèì àãåíòîì (ÄÏÀ), ñîäåðaeàùåìñÿ â ñïåöèàëüíîì ïðåïàðàòå, ââîäèìîì èëè íàêàïëèâàþùåìñÿ â îïóõîëè [2,3]. Òàêîå ïðåèìóùåñòâåííîå ïîãëîùåíèå ïîçâîëÿåò îáåñïå÷èòü â îáëàñòè ëîêàëèçàöèè ÄÏÀ âåëè÷èíó ïîãëîùåííîé äîçû â 1,5 -3 ðàçà áîëüøå, ÷åì â îêðóaeàþùèõ çäîðîâûõ òêàíÿõ [4 -7].…”