Pharmaceuticals and Personal Care Products in the Environment: What Progress Has Been Made in Addressing the Big Research Questions?

Boxall, Alistair B. A.; Brooks, Bryan W.

doi:10.1002/etc.5827

Cited by 6 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Very recently, a special issue shedding light on the progress achieved over the past decade and the remaining open questions regarding the challenge of pharmaceuticals and personal care products (PPCPs) in the environment was published in Environmental Toxicology and Chemistry . The special issue revisited from scientific, regulatory, and technical angles the pivotal questions raised in the “20 Questions Paper” from 2012 and outlined research priorities for the next decade …”

Section: Pharmaceuticals and Hormonesmentioning

confidence: 99%

Water Analysis: Emerging Contaminants and Current Issues

Richardson,

Manasfi

2024

Anal. Chem.

View full text Add to dashboard Cite

BACKGROUND AND TRENDSThis biennial review covers developments in water analysis for emerging environmental contaminants mainly over the period of September 2021−December 2023 (with a few in early 2024). Analytical Chemistry's policy is to limit reviews to a maximum of ∼250 significant references and to mainly focus on new trends. Therefore, only a small fraction of the quality research publications are discussed. The previous Water Analysis review (with Thomas Ternes) was published in 2022. 1 This year, Tarek Manasfi joined to cover the section on pharmaceuticals and hormones. We welcome any comments you have on this Review

show abstract

Section: Pharmaceuticals and Hormonesmentioning

confidence: 99%

Water Analysis: Emerging Contaminants and Current Issues

Richardson,

Manasfi

2024

Anal. Chem.

View full text Add to dashboard Cite

show abstract

The Tissue‐Specific Eco‐Exposome: Differential Pharmaceutical Bioaccumulation and Disposition in Fish among Trophic Positions

Sims,

Cole,

Moran

et al. 2024

Enviro Toxic and Chemistry

Self Cite

View full text Add to dashboard Cite

Though bioaccumulation of pharmaceuticals by aquatic organisms continues to receive scientific attention, the internal disposition of these contaminants among different tissue compartments of fish species has been infrequently investigated, particularly among fish at different trophic positions. We tested a human to fish biological read‐across hypothesis for contaminant disposition by examining tissue‐specific accumulation in three understudied species, longnose gar (Lepisosteus osseus; piscivore), gizzard shad (Dorosoma cepedianum; planktivore/detritivore), and smallmouth buffalo (Ictiobus bubalus; benthivore), from a river influenced by municipal effluent discharge. In addition to surface water, fish plasma, and brain, gill, gonad, liver, and lateral muscle fillet tissues were analyzed via isotope dilution liquid chromatography tandem mass spectrometry. Caffeine and sucralose, two common effluent tracers, were quantitated at low micrograms per liter levels in surface water, while an anticonvulsant, carbamazepine, was observed at levels up to 37 ng/L. The selective serotonin reuptake inhibitors (SSRIs) fluoxetine and sertraline and primary metabolites were detected in at least one tissue of all three species at low micrograms per kilogram concentrations. Within each species, brain and liver of select fish contained the highest levels of SSRIs compared to plasma and other tissues, which is generally consistent with human tissue disposition patterns. However, we observed differential accumulation among specific tissue types and species. For example, mean levels of sertraline in brain and liver tissues were 13.4 µg/kg and 1.5 µg/kg in gizzard shad and 1.3 µg/kg and 7.3 µg/kg in longnose gar, respectively. In contrast, smallmouth buffalo did not consistently accumulate SSRIs to detectable levels. Tissue‐specific eco‐exposome efforts are necessary to understand mechanisms associated with such marked bioaccumulation and internal dispositional differences among freshwater fish species occupying different trophic positions. Environ Toxicol Chem 2024;00:1–9. © 2024 The Author(s). Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

show abstract

Development of a probabilistic risk model for pharmaceuticals in the environment under population and wastewater treatment scenarios

Welch,

Grung,

Madsen

et al. 2024

Integr Envir Assess & Manag

View full text Add to dashboard Cite

Preparing for future environmental pressures requires projections of how relevant risks will change over time. Current regulatory models of environmental risk assessment (ERA) of pollutants such as pharmaceuticals could be improved by considering the influence of global change factors (e.g., population growth) and by presenting uncertainty more transparently. In this article, we present the development of a prototype object‐oriented Bayesian network (BN) for the prediction of environmental risk for six high‐priority pharmaceuticals across 36 scenarios: current and three future population scenarios, combined with infrastructure scenarios, in three Norwegian counties. We compare the risk, characterized by probability distributions of risk quotients (RQs), across scenarios and pharmaceuticals. Our results suggest that RQs would be greatest in rural counties, due to the lower development of current wastewater treatment facilities, but that these areas consequently have the most potential for risk mitigation. This pattern intensifies under higher population growth scenarios. With this prototype, we developed a hierarchical probabilistic model and demonstrated its potential in forecasting the environmental risk of chemical stressors under plausible demographic and management scenarios, contributing to the further development of BNs for ERA. Integr Environ Assess Manag 2024;00:1–21. © 2024 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).

show abstract

Pharmaceuticals and Personal Care Products in the Environment: What Progress Has Been Made in Addressing the Big Research Questions?

Cited by 6 publications

References 22 publications

Water Analysis: Emerging Contaminants and Current Issues

Water Analysis: Emerging Contaminants and Current Issues

The Tissue‐Specific Eco‐Exposome: Differential Pharmaceutical Bioaccumulation and Disposition in Fish among Trophic Positions

Development of a probabilistic risk model for pharmaceuticals in the environment under population and wastewater treatment scenarios

Contact Info

Product

Resources

About