Pharmaceuticals and Personal Care Products

Angnes, Lúcio

doi:10.1007/978-1-4939-1301-5_9

Cited by 8 publications

(6 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Electrometric methods using sensors and biosensors, which is now a well established method, with advantage of simplicity, short measurement time, adequate precision and accuracy, and the ability to measure the activity of the target species in colored or cloudy samples. Although sensors had found wide applications for drug quality control [23][24][25][26][27][28], to the best of our knowledge, few galantamine potentiometric sensors were found in literature. Abdel-Haleem et al, recently published the fabrication of PVC membrane, coated-wire, and carbon-paste sensors for potentiometric determination of galantamine hydrobromide [35].…”

Section: Resultsmentioning

confidence: 99%

“…Chemical sensors and biosensors are shown to offer alternative solutions, capable of satisfying the increasing demand for precise analytical information at lower cost through devices that require relatively simple instrumentation. Ideally, a sensor-based system needs only little, if any, pre-treatment of the sample and possible interfacing with FIA systems [23][24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Highly sensitive enzymatic potentiometric approaches for anticholinesterase drugs rugs

et al. 2018

View full text Add to dashboard Cite

T HE PRESENT study described a novel application of simple potentiometric biosensors for analysis of anti-cholinesterase (Alzheimer) drugs in vitro. The proposed method was based on inhibition of acetylcholineesterase enzyme (AChE) by Alzheimer drugs namely; donepezil (DOP) and galantamine (GAL) in addition to biperdien (BP) and ipratropium (IPBr). Based on the relative inhibition action of drug on AChE activity, different sensitivities were recorded ranging between 0 to 18.0 ng, 0 to 90.0 ng, 0 to 4.69 µg and 0 to 9.96 µg mL -1 for the aforementioned drugs in the same order depending on the nature of drugs and their corresponding LD50 values. The proposed procedures were successfully applied for determination of drugs in pharmaceutical formulation and biological samples with sensitivity and accuracy comparable with the official method. The presented approach can be suggested for testing of pharmaceutical preparation toxicity against cholinesterase enzymes in vitro.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Highly sensitive enzymatic potentiometric approaches for anticholinesterase drugs rugs

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Electroanalytical techniques with their advantages of adequate sensitivity with considerable operation coast and short measurement time are now well established technique for pharmaceutical analysis [14][15][16][17][18][19][20][21][22][23]. To the best of our knowledge, no electroanalytical studies were performed for determination of trospium, therefore, the aim of present work was to establish a novel, simple, accurate and precise potentiometric screen printed sensor using the macrocyclic/nanomaterial composite for potentiometric determination of TRO in both pharmaceutical and biological samples.…”

Section: Introductionmentioning

confidence: 99%

Novel Electroanalytical Technique for Determination of Trospium Hydrochloride

2020

View full text Add to dashboard Cite

The present work describes for the first time the fabrication of a novel disposable screen printed sensor for the potentiometric determination of trospium hydrochloride (TRO). The cited sensors were based on alpha cyclodextrin as molecular recognition element and multi walled carbon nanotubes (MWCNTs) as transducer. Comprehensive and deep investigations were done on the sensing membrane components including the nature of sensing material, cavity size, additives, and plasticizers in addition to nanomaterial. The fabricated sensors were highly sensitive, selective and accurate towards TRO with Nernstian slope 60.8± 0.5 mV decade -1 in the concentration range from 10 -6 to 10 -2 mol L -1 . This can be attributed to the incorporation of MWCNTs to the electrode matrix which accelerates response time and improves potential reading stability. The fabricated sensors were used for the potentiometric determination of TRO under batch and flow injection technique with agreeable recoveries compared with the standard methods. Moreover, the high selectivity of the sensors towards TRO in presence of its degradation products suggests application of this method as stability indicating technique for TRO quality control.

show abstract

“…Ideally, a sensor-based system needs only little, if any, pre-treatment of the sample and possible interfacing with FIA systems [12][13][14][15][16]. Ideally, a sensor-based system needs only little, if any, pre-treatment of the sample and possible interfacing with FIA systems [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…Chemical sensors and biosensors are known to offer alternative solutions capable of satisfying the increasing demand for precise analytical information at lower cost through devices that require relatively simple instrumentation. Ideally, a sensor-based system needs only little, if any, pre-treatment of the sample and possible interfacing with FIA systems [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Novel Calixarene/Carbon Nanotubes Based Screen Printed Sensors for Flow Injection Potentiometric Determination of Naproxen

et al. 2018

View full text Add to dashboard Cite

Novel sensitive disposable sensors have been introduced for potentiometric determination of naproxen (NAP) based on single‐walled carbon nanotubes‐polyvinyl chloride (SWNTs‐PVC) composite incorporated of calix[4]arene as host‐guest molecular recognition element. The electrode matrix composition was optimized on the basis of the nature and content of the sensing element, cationic sites, plasticizer and nanomaterial. Remarkable selectivity and sensitivity towards NAP was achieved in the concentration range from 10−8 to 10−2 mol L−1 with anionic Nernstian compliance −61.0±0.0 mV decade−1. Modification with calixarene and carbon nanotubes improved the sensors performance through formation of NAP‐calixarene inclusion complex and promotion of the electron‐transfer processes which enhance the potential stability, response time, and shelf lifetime of the sensor. The proposed sensors were successfully applied for the potentiometric assay of NAP in dosage formulation and biological fluids under batch and flow injection analysis (FIA) conditions with average recoveries agreeable with the reported official methods.

show abstract

Pharmaceuticals and Personal Care Products

Cited by 8 publications

References 108 publications

Highly sensitive enzymatic potentiometric approaches for anticholinesterase drugs rugs

Highly sensitive enzymatic potentiometric approaches for anticholinesterase drugs rugs

Novel Electroanalytical Technique for Determination of Trospium Hydrochloride

Novel Calixarene/Carbon Nanotubes Based Screen Printed Sensors for Flow Injection Potentiometric Determination of Naproxen

Contact Info

Product

Resources

About