Pharmaceuticals and iodinated contrast media in a hospital wastewater: A case study to analyse their presence and characterise their environmental risk and hazard

Mendoza, Alberto Obregón; Aceña, Jaume; Pérez, Sandra; Alda, Miren López de; Barceló, Damià; Gil, Á.; Valcárcel, Y.

doi:10.1016/j.envres.2015.04.003

Cited by 181 publications

(60 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The concentration of SMZ in the river water (n.d-580.4 ng/L) was the same as in the Huangpu (2.1-623.3 ng/L, Jiang et al, 2011;19.9-389.4 ng/L, Chen and Zhou, 2014), urban surface waters of Beijing in China (n.d-123 ng/L, Li et al, 2015) and Pearl Rivers in China (n.d-1080 ng/L, Yang et al, 2011), and slightly higher than in the Yangtze Estuary in China (0.53-89.1 ng/L, Yan et al, 2013), the Ebro River in Spain (2.5-65.2 ng/L, García-Galán et al, 2011), and stream water in North America (n.d-120 ng/L, Kolpin et al, 2002). The concentrations of the other target sulfonamides, including SMX (n.d-3.1 ng/L), SD (n.d-14.8 ng/L), and SP (n.d-3.2 ng/L), were lower than in other river waters in China and in countries such as Beijing (China) , North America (Kolpin et al, 2002), Spain (García-Galán et al, 2011;Boleda et al, 2013;Mendoza et al, 2015), France (Tamtam et al, 2008), and Australia (Watkinson et al, 2009) (Table 2).…”

Section: Occurrence Of Antibiotics In Watermentioning

confidence: 99%

Occurrence and risk assessment of antibiotics in river water in Hong Kong

Deng

Zheng

et al. 2016

Ecotoxicology and Environmental Safety

135

View full text Add to dashboard Cite

Section: Occurrence Of Antibiotics In Watermentioning

confidence: 99%

Occurrence and risk assessment of antibiotics in river water in Hong Kong

Deng

Zheng

et al. 2016

Ecotoxicology and Environmental Safety

135

View full text Add to dashboard Cite

“…It has been widely reported that domestic sewage contains high concentrations of APIs and that in many cases, they are not effectively removed by wastewater treatment plants (Herberer 2002;Cardoso et al 2014;Barra Caracciolo et al 2015). Even greater pharmaceutical concentrations were noted in wastewater generated by hospitals advocating the consideration of specific treatments for such effluents before being discharged into the public sewage system (Mendoza et al 2015). All in all, insufficient removal of APIs at wastewater treatment plants eventually leads to their discharge into the aquatic environment, mostly rivers and streams which serve as receivers for treated wastewater.…”

Section: Sources Of Pharmaceuticals In the Environmentmentioning

confidence: 99%

Pharmaceutical pollution of aquatic environment: an emerging and enormous challenge

Rzymski

Drewek

Klimaszyk

2017

Limnological Review

View full text Add to dashboard Cite

Abstract:The global use of pharmaceuticals is on the systematic rise and leads to contamination of surface waters with xenobiotic compounds with a wide range of bioactivity. Waters that receive urban and medical effluents are particularly threatened. The presence of pharmaceuticals in these ecosystems can lead to unpredictable ecological impacts and responses, and may also have an impact on human health. At the same time the identification and quantification of these chemicals, to a large extent remains a subject to scientific investigation than part of a thorough monitoring programme. Their biological effects on aquatic organisms are mainly recognized experimentally and often using concentrations far exceeding environmentally relevant levels. This review paper defines the main sources of pharmaceuticals in the aquatic environment, discusses the fate of these compounds and summarizes the current state-of-the-art of pharmaceutical monitoring in Polish surface waters.

show abstract

“…Santos et al [60] found dexamethasone levels in hospital effluents ranging from undetectable to 352 ng/L. Ibuprofen is commonly detected in hospital effluents at ng/L levels (119 to 7090) [13,102], or at ug/L levels (3.11) [107]. Metoprolol was found at levels from 1.57 to 32.8 ug/L in Suffolk County, NY [74] …”

Section: Metabolism and Excretionmentioning

confidence: 99%

“…Hospital effluents are recognized as major sources of drugs [2,60,74,102]. For most of the drugs studied herein, the official (FDA) manufacturer label provided adequate insight into the urinary and fecal excretion of the drug and its metabolites.…”

Section: Metabolism and Excretionmentioning

confidence: 99%

“…Thus there appears to be poor correlation between the laboratory toxicity test results and the REACH PBT toxicity scoring. Recently, Mendoza et al [102] analyzed 25 drugs and radiocontrast agents in effluents from a hospital. PBT and environmental risk values from the Stockholm County Council were presented.…”

Section: Pbt Environmental Risk Ratio and Ecotoxicity Analysismentioning

confidence: 99%

See 1 more Smart Citation

Pharmaceutical Dispensing and Wasting In Health Care Facilities, Amounts, Costs and Evaluation of Potential Ecologic Effects

Mankes¹,

Silver²

2017

SOJPPS

View full text Add to dashboard Cite

Drug waste from hospitals contributes to environmental contamination. Patient excreta, bathing or discarding of excess drugs are some sources of drug waste. We report on the wasting of 84 drugs of 14 therapeutic classes in two hospitals in Albany, NY. We consider drug metabolism, excretion, disposal and ecotoxicity in strategies for reducing drug waste, costs and potential environmental damage.Medication (12,345) and waste collection (199) records for: drugs dispensed, returned and wasted were examined. Of 2,700 drugs available, 84 drugs from 14 classes, weighing 56 kg were dispensed to patients, and 2.3 kg were wasted. Twelve drugs accounted for 80 percent of the drug waste and cost $111,000. Of the top wasted and dispensed drugs, all but ibuprofen are persistant and none were bioaccumulative. Ibuprofen, ipratropium ondansetron and oxymetazoline are "very highly toxic" or "highly toxic". Environmental Risk Ratio (PEC/PNEC) for the 20 top drugs were"Insignificant" or "Cannot Be Excluded".Acetazolamide is the most toxic to fish. Dexamethasone has the greatest chronic toxicity to Ceriodaphnia. Ibuprofen is predicted to be very highly toxic (acute and chronic) to zebra mussel, crab and fish. Neostigmine is the most acutely toxic (LC50<1 mg/L) to Daphnia. Ondansetron is the most acutely toxic to green algae. All but 2 of the drugs were 5 to 100% excreted. Fourteen were metabolised. Active metabolites were formed from 2 drugs. Nicardipine, ondansetron and prednisone formed drug conjugates which were excreted. Incineration was the manufacturer's recommended disposal method.We recommend excess drugs be returned to the hospital pharmacy for disposal by incineration. Drug use and disposal should be monitored by an expert committee according to recognized guidelines of pharmaceutical management. Knowledge of the adverse impacts from the release of highly toxic drugs into the environment must influence drug selection and disposal.Key words: Waste; Ecotoxicity; Wastewater; Abbreviations AMCH = Academic Medical Center Hospital; ASTER = Assessment Tools for the Evaluation of Risk. United States Environmental Protection Agency https://archive.epa.gov/med/med_archive_03/web/html/ aster.html Last accessed 6/4/17; B = Bioaccumulation is the general term describing a process by which chemicals are taken up by an organism either directly from exposure to a contaminated medium or by consumption of food containing the chemical; EC50 = Effective Concentration producing an adverse effect in 50% of a test species; EbC50 or ErC50 = EC50 in terms of reduction of growth rate; EyC50 = EC50 in terms of change in biomass yield; Ecosar = Ecologic Structure Activity Relationships is a computerized predictive system that estimates aquatic toxicity. The program estimates a chemical's acute (short-term) toxicity and chronic (long-term or delayed) toxicity to aquatic organisms such as fish, invertebrates, and plants by using computerized Structure Activity Relationships (SARs). https://www.epa.gov/tsca-screening-tools/ ecological-structure-...

show abstract

Pharmaceuticals and iodinated contrast media in a hospital wastewater: A case study to analyse their presence and characterise their environmental risk and hazard

Cited by 181 publications

References 88 publications

Occurrence and risk assessment of antibiotics in river water in Hong Kong

Occurrence and risk assessment of antibiotics in river water in Hong Kong

Pharmaceutical pollution of aquatic environment: an emerging and enormous challenge

Pharmaceutical Dispensing and Wasting In Health Care Facilities, Amounts, Costs and Evaluation of Potential Ecologic Effects

Contact Info

Product

Resources

About