Pharmaceutical Uses of Chitosan in the Medical Field

Mustafa, Alef; Cadar, Emin

doi:10.26417/ejis.v3i1.p35-40

Cited by 8 publications

(8 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The anticoagulant activity of the chitosan and its derivatives is also greatly influenced by many factors such as degree of sulfonation (Xiong et al, 2011, Shagdarova et al, 2016, Subhapradha et al, 2013, Yang et al, 2013, Drozd et al, 2019, Song et al, 2018, Ouerghemmi et al, 2018, Drozd et al, 2017, Skorik et al, 2017, Ragab et al, 2018). Further, the N-alkylation of chitosan to primary or secondary chitosan derivatives and finally to quaternary chitosan derivatives increase the water solubility of the chitosan derivatives (Mustafa et al, 2015, Szymańska and Winnicka, 2015, Yadu et al, 2017, Cheung et al, 2015, Avadi et al, 2004). Based on the literature, the authors developed newer chitosan derivatives as anticoagulants.…”

Section: Discussionmentioning

confidence: 99%

“…2) is a natural polyaminosaccharide with a non-toxic, non-allergenic, biocompatible, and biodegradable characteristic. These properties of chitosan make it a good pharmaceutical excipient and a carrier for the preparation of prodrugs, as an accelerator of wound healing, and as a physiological substance due to its anticancer, antimicrobial, immune-modulator, anti-cholesterolemic, and antioxidant properties (Mustafa et al, 2015, Szymańska and Winnicka, 2015, Yadu et al, 2017, Cheung et al, 2015, Ngo and Kim, 2014, Szymańska and Winnicka, 2012, Vladimir et al, 2006, Avadi et al, 2004). Also, chitosan is a polymer having a primary amino group, which is a possible site for substitution in the chitosan and N-alkyl chitosan had previously been reported to have antibacterial activity (Avadi et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis, characterization and anticoagulant activity of chitosan derivatives

Imran

Sajwan

Alsuwayt

et al. 2020

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

Chitosan derivatives are reported as anticoagulants in the literature. This work was undertaken to develop novel chitosan derivatives as anticoagulants. The sulfonated derivatives of chitosan were formed by the reaction of chitosan derivatives with chlorosulfonic acid in N,N-dimethylformamide. The structures of these derivatives were established by FTIR and 1H NMR spectra. The prepared derivatives were evaluated for their in vivo anticoagulant effects by the tail bleeding method in Wistar rats utilizing nicoumalone as a standard drug. The results revealed that the sulfonation of the chitosan increases its anticoagulant activity. The developed compounds exhibited faster onset of action and potency than nicoumalone after one hour of the drug administration. The sulphated N-alkyl derivatives of chitosan were more potent anticoagulants than sulfated quaternary derivatives/sulfated chitosan. It is also suggested to develop analogs of Ethyl chitosan sulfate (4b) and Benzyl chitosan sulfate (4c), which may provide some more fruitful anticoagulants having faster onset of action as well as longer duration of action and possessing a balanced hydrophilic/lipophilic character.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and anticoagulant activity of chitosan derivatives

Imran

Sajwan

Alsuwayt

et al. 2020

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

show abstract

“…In reference to the physico-chemical properties it can be noted that chitin is insoluble in water and exists mainly in two crystalline polymorphic forms, α and β. α-chitin is found in the exoskeleton of arthropods, in insects and in fungal and yeast cell walls. β-chitin occurs less frequently in nature than α-chitin, but can be extracted from squid pens (Mustafa A., 2015).…”

Section: Characterization Of Chitin Chitosan and Chito-oligosacharides (Chos)mentioning

confidence: 99%

“…Residual proteins in chitin and chitosan could cause allergic reactions such as hypersensitivity. The protein content in a sample depends on the source of the sample and, especially, on the method of preparation (Mustafa A., 2015).…”

Section: Biocompatibilitymentioning

confidence: 99%

Studies on Chitosan, Chitin and Chitooligosaccharides and Their Biomedical Properties

Ibram

2021

European Journal of Natural Sciences and Medicine

View full text Add to dashboard Cite

Research in healthcare involves the use of natural resources in the manufacture of pharmaceutical products. Chito-oligosaccharides (CHOS) are described as homo- or heterooligomers of N-acetylglucosamine and D-glucosamine. As a starting material for CHOS production chitin or chitosan can be used. When it comes to the medical field, there are indications that CHOS may be developed and used as drugs against asthma, antibacterial agents, ingredients in wound-dressings and vectors in gene-therapy. The methods of production can rely on enzymatic conversions, chemical methods or combinations of these methods. There is ample literature concerning the biological effects of chitosans, but relatively little is known about the effects of CHOS, and the mechanisms behind observed bioactivities are generally poorly understood. This review is focused on the characterization of chitin and chitosan by presenting the biological properties, and on the enzymatic production of CHOS, and on further separation and purification methods for producing well-defined mixtures and also provides an overview of some of the most promising applications of CHOS.

show abstract

“…unsaturated fats and bile acids. Interaction between the chitosan and anionic surface active materials (phospholipids, bile acids) mainly relies upon these three sorts of reactive functional groups: the amino gathering at C2 position and at essential and the optional hydroxyl bunches at C-3 and C-6 positions, respectively 61,62 . Albeit extraordinary exertion has been made to discover a connection between's the physicochemical qualities of chitosan and its fatrestricting limit, just some noteworthy connections have been shown 57 .…”

Section: Hypolipidemic and Hypocholesterolemic Effectmentioning

confidence: 99%

Untitled

2018

IJPSR

View full text Add to dashboard Cite

Chitin is the second most important natural amino polysaccharide polymer after cellulose in the world. The main sources exploited are marine crustaceans, shrimp, and crab apart from that some other lobstera, insects, sulphur butter and fungi. Chitosan is the most important natural based common cationic polymer got from chitin has gotten developing consideration for the most part due to their biodegradable , biocompatible, bio-renewable and non-lethal properties. The deacetylated chitin derivative chitosan is a useful and interesting bioactive polymer; it has a large pharmaceutical application either. It has numerous reactive amino side groups, which offer possibilities of chemical modifications, formation of a large variety of beneficial derivatives. Chitosan has been found to be used as a support material for pharmaceutical application, gene delivery, cell culture, and tissue engineering. This review is based on the various pharmacological activity of chitosan such as wound healing, anti-hypertensive, anti-cancer, blood coagulant, anti-coagulant, anti-ulcer, anti-microbial, anti-viral, hypolipidemic and hypocholesterolemic etc.

show abstract

Pharmaceutical Uses of Chitosan in the Medical Field

Cited by 8 publications

References 7 publications

Synthesis, characterization and anticoagulant activity of chitosan derivatives

Synthesis, characterization and anticoagulant activity of chitosan derivatives

Studies on Chitosan, Chitin and Chitooligosaccharides and Their Biomedical Properties

Untitled

Contact Info

Product

Resources

About