Pharmaceutical Polymer Gels in Drug Delivery

Aggarwal, Geeta; Nagpal, Manju

doi:10.1007/978-981-10-6080-9_10

Cited by 16 publications

(13 citation statements)

References 78 publications

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“…During the formation of the xerogel, the wet gel undergoes a large volume shrinkage and is easy to crack. To retain the original network of the gel and avoid cracking, supercritical drying is an essential way to dry the wet gel and an aerogel, whose liquid phase is replaced with gas, is obtained [ 125 ].…”

Section: Crystal Growth From Solution Processmentioning

confidence: 99%

A Review on Gallium Oxide Materials from Solution Processes

et al. 2022

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Gallium oxide (Ga2O3) materials can be fabricated via various methods or processes. It is often mentioned that it possesses different polymorphs (α-, β-, γ-, δ- and ε-Ga2O3) and excellent physical and chemical properties. The basic properties, crystalline structure, band gap, density of states, and other properties of Ga2O3 will be discussed in this article. This article extensively discusses synthesis of pure Ga2O3, co-doped Ga2O3 and Ga2O3-metal oxide composite and Ga2O3/metal oxide heterostructure nanomaterials via solution-based methods mainly sol-gel, hydrothermal, chemical bath methods, solvothermal, forced hydrolysis, reflux condensation, and electrochemical deposition methods. The influence of the type of precursor solution and the synthesis conditions on the morphology, size, and properties of final products is thoroughly described. Furthermore, the applications of Ga2O3 will be introduced and discussed from these solution processes, such as deep ultraviolet photodetector, gas sensors, pH sensors, photocatalytic and photodegradation, and other applications. In addition, research progress and future outlook are identified.

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Section: Crystal Growth From Solution Processmentioning

confidence: 99%

A Review on Gallium Oxide Materials from Solution Processes

et al. 2022

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“…The gelation of chitosan can be obtained by the concentration of aqueous solutions. The gelation of carboxymethyl cellulose occurs in the presence of polyvalent cation [156]. So far, these water-soluble polysaccharides have been used as thickening agents or gelling agents in nanoemulsions.…”

Section: Nanoemulsion Stabilizermentioning

confidence: 99%

Food-Grade Nanoemulsions: Preparation, Stability and Application in Encapsulation of Bioactive Compounds

et al. 2019

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Nanoemulsions have attracted significant attention in food fields and can increase the functionality of the bioactive compounds contained within them. In this paper, the preparation methods, including low-energy and high-energy methods, were first reviewed. Second, the physical and chemical destabilization mechanisms of nanoemulsions, such as gravitational separation (creaming or sedimentation), flocculation, coalescence, Ostwald ripening, lipid oxidation and so on, were reviewed. Then, the impact of different stabilizers, including emulsifiers, weighting agents, texture modifiers (thickening agents and gelling agents), ripening inhibitors, antioxidants and chelating agents, on the physicochemical stability of nanoemulsions were discussed. Finally, the applications of nanoemulsions for the delivery of functional ingredients, including bioactive lipids, essential oil, flavor compounds, vitamins, phenolic compounds and carotenoids, were summarized. This review can provide some reference for the selection of preparation methods and stabilizers that will improve performance in nanoemulsion-based products and expand their usage.

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“…Gelation of dilute solutions of sodium alginate takes place upon contact with simulated gastric fluid; when divalent cations (usually calcium ions) interact ionically by a co-operative process involving consecutive blocks of guluronic residues in the α -l-guluronic acid (G) blocks of the alginate chain, resulting in the formation of a three dimensional network that is usually described by an "egg-box" model. It is the ion exchange process between sodium and calcium ions that are supposed to be responsible for the swelling and subsequent degradation of sodium alginate in the colon 26,27 .…”

Section: Polymers Used In This Studymentioning

confidence: 99%

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2019

IJPSR

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Conventional oral dosage forms posses low bioavailability problems due to their rapid gastric transition from the stomach. Especially some drug which is less soluble in alkaline pH and producing local action in the stomach gets rapidly emptied and do not get enough residence time in the stomach. As a result, there is a requirement of increased frequency of dose. To overcome such type of problems various efforts have been made by developing the gastro-retentive drug delivery system. The gastro-retentive drug delivery system comprised mainly of floating, mucoadhesive, swellable and high-density systems have emerged as a current approach of enhancing the bioavailability and controlled delivery of drugs that exhibit an absorption window. So, oral controlled release and site-specific drug delivery system has been of great interest in the pharmaceutical field to achieve an improved therapeutic advantage. In this review, we have discussed the various approaches to produce gastro retention of drug delivery system, with special discussion on floating in-situ gel system for stomach specific drug delivery. As it offers several advantages like sustained and prolonged action in comparison to conventional drug delivery systems and increases the bioavailability of drug as well as produce patient compliance by reducing dosing frequency.

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Pharmaceutical Polymer Gels in Drug Delivery

Cited by 16 publications

References 78 publications

A Review on Gallium Oxide Materials from Solution Processes

A Review on Gallium Oxide Materials from Solution Processes

Food-Grade Nanoemulsions: Preparation, Stability and Application in Encapsulation of Bioactive Compounds

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