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Abstract

Conventional oral dosage forms posses low bioavailability problems due to their rapid gastric transition from the stomach. Especially some drug which is less soluble in alkaline pH and producing local action in the stomach gets rapidly emptied and do not get enough residence time in the stomach. As a result, there is a requirement of increased frequency of dose. To overcome such type of problems various efforts have been made by developing the gastro-retentive drug delivery system. The gastro-retentive drug delivery system comprised mainly of floating, mucoadhesive, swellable and high-density systems have emerged as a current approach of enhancing the bioavailability and controlled delivery of drugs that exhibit an absorption window. So, oral controlled release and site-specific drug delivery system has been of great interest in the pharmaceutical field to achieve an improved therapeutic advantage. In this review, we have discussed the various approaches to produce gastro retention of drug delivery system, with special discussion on floating in-situ gel system for stomach specific drug delivery. As it offers several advantages like sustained and prolonged action in comparison to conventional drug delivery systems and increases the bioavailability of drug as well as produce patient compliance by reducing dosing frequency.

Advances in drug delivery systems, challenges and future directions

“…The pectin-based formulation was created to ensure that Metformin loaded pectin (PCM) was distributed continuously. Because pectin is water soluble, an organic solvent is not required [ 88 , 89 ].…”