Pharmaceutical Evaluation of Hollow-Type Suppotitories. Part XXIII. Pharmacokinetics and Pharmacodynamics of Human Chorionic Gonadotropin (hCG) after Rectal Administration of Hollow-Type Suppositories Containing hCG.

Kowari, Kouji; Hirosawa, Iori; Kurai, Hirono; Utoguchi, Naoki; Fujii, Makiko; Watanabe, Yoshihisa

doi:10.1248/bpb.25.678

Cited by 10 publications

(3 citation statements)

References 13 publications

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“…Hollow-type suppositories have been developed and modified to enhance the absorption of various drugs (Watanabe et al, 1986; Watanabe et al, 1986; Matsumoto et al, 1989; Uekama et al, 1995; Watanabe et al, 1998; Kowari et al, 2002; Kaewnopparat et al, 2004; Shiohira et al, 2009). This type of suppository essentially contains a hollow space in the center that is filled with the drug in solid, liquid, or semi-solid form.…”

Section: Conventional Rectal Drug Delivery Approachesmentioning

confidence: 99%

Physiological and Pharmaceutical Considerations for Rectal Drug Formulations

Hua

2019

Front. Pharmacol.

129

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Although the oral route is the most convenient route for drug administration, there are a number of circumstances where this is not possible from either a clinical or pharmaceutical perspective. In these cases, the rectal route may represent a practical alternative and can be used to administer drugs for both local and systemic actions. The environment in the rectum is considered relatively constant and stable and has low enzymatic activity in comparison to other sections of the gastrointestinal tract. In addition, drugs can partially bypass the liver following systemic absorption, which reduces the hepatic first-pass effect. Therefore, rectal drug delivery can provide significant local and systemic levels for various drugs, despite the relatively small surface area of the rectal mucosa. Further development and optimization of rectal drug formulations have led to improvements in drug bioavailability, formulation retention, and drug release kinetics. However, despite the pharmaceutical advances in rectal drug delivery, very few of them have translated to the clinical phase. This review will address the physiological and pharmaceutical considerations influencing rectal drug delivery as well as the conventional and novel drug delivery approaches. The translational challenges and development aspects of novel formulations will also be discussed.

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Section: Conventional Rectal Drug Delivery Approachesmentioning

confidence: 99%

Physiological and Pharmaceutical Considerations for Rectal Drug Formulations

Hua

2019

Front. Pharmacol.

129

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“…7 α-CD enhanced the rectal absorption of morphine and human chorionic gonadotropin by increasing their mucosal permeability and reducing their degradation. 154,155 CDs enhance rectal drug stability either by inhibiting the drug/vehicle interaction (by making the drug insoluble in oleaginous base) or by inhibiting the drug bioconversion in the rectum. α-CD improved the rectal bioavailability of morphine by inhibiting the upward movement of the drug from areas impacted by first pass metabolism.…”

Section: Rectal Drug Deliverymentioning

confidence: 99%

Cyclodextrins in drug delivery: An updated review

et al. 2005

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The purpose of this review is to discuss and summarize some of the interesting findings and applications of cyclodextrins (CDs) and their derivatives in different areas of drug delivery, particularly in protein and peptide drug delivery and gene delivery. The article highlights important CD applications in the design of various novel delivery systems like liposomes, microspheres, microcapsules, and nanoparticles. In addition to their well-known effects on drug solubility and dissolution, bioavailability, safety, and stability, their use as excipients in drug formulation are also discussed in this article. The article also focuses on various factors influencing inclusion complex formation because an understanding of the same is necessary for proper handling of these versatile materials. Some important considerations in selecting CDs in drug formulation such as their commercial availability, regulatory status, and patent status are also summarized. CDs, because of their continuing ability to find several novel applications in drug delivery, are expected to solve many problems associated with the delivery of different novel drugs through different delivery routes.

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“…β-CD enhanced the antiviral activity of ganciclovir on human cytomegalovirus clinical strains and the resultant increase in the drug potency reduced the drug toxicity. [52–54] The toxicities associated with crystallization of poorly water-soluble drugs in parenteral formulations can often be reduced by the formation of soluble drug:CD complexes.…”

Section: Cyclodextrin Effects On Important Drug Properties In Formulamentioning

confidence: 99%

Cyclodextrins in delivery systems: Applications

2010

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Cyclodextrins (CDs) are a family of cyclic oligosaccharides with a hydrophilic outer surface and a lipophilic central cavity. CD molecules are relatively large with a number of hydrogen donors and acceptors and, thus in general, they do not permeate lipophilic membranes. In the pharmaceutical industry, CDs have mainly been used as complexing agents to increase aqueous solubility of poorly soluble drugs and to increase their bioavailability and stability. CDs are used in pharmaceutical applications for numerous purposes, including improving the bioavailability of drugs. Current CD-based therapeutics is described and possible future applications are discussed. CD-containing polymers are reviewed and their use in drug delivery is presented. Of specific interest is the use of CD-containing polymers to provide unique capabilities for the delivery of nucleic acids. Studies in both humans and animals have shown that CDs can be used to improve drug delivery from almost any type of drug formulation. Currently, there are approximately 30 different pharmaceutical products worldwide containing drug/CD complexes in the market.

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Pharmaceutical Evaluation of Hollow-Type Suppotitories. Part XXIII. Pharmacokinetics and Pharmacodynamics of Human Chorionic Gonadotropin (hCG) after Rectal Administration of Hollow-Type Suppositories Containing hCG.

Cited by 10 publications

References 13 publications

Physiological and Pharmaceutical Considerations for Rectal Drug Formulations

Physiological and Pharmaceutical Considerations for Rectal Drug Formulations

Cyclodextrins in drug delivery: An updated review

Cyclodextrins in delivery systems: Applications

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