Pharmaceutical development of metronidazole loaded transferosome gel for skin delivery

Abstract

Objective: The focus of this research was out whether a transfersomal gel formulation for transdermal delivery of Metronidazole. Methods: Azole Antifungals include metronidazole, which is used to treat fungal and yeast infections. Transferosomes are supra-molecular aggregates that are ultra-flexible and have a high ability to penetrate mammalian skin intact. Drug encapsulation in various transfersomal formulations containing various ratios of different drug concentrations (0.05, 0.1, 0.2, 0.3, 0.4, 0.5 g) and Carbopol-934 (0.5, 1, 2 g) is being researched for use as a transferosomal gel.Results: Entrapment efficiency (EE %), drug content, in-vitro skin permeation tests, and stability investigations were performed on the produced formulations. The vesicles were spherical in shape, as confirmed by Transmission Electron Microscopy. Metronidazole was successfully pinned with a standardised drug content in all formulations, according to the resultsThe 0.1 g Metronidazole optimised transferosome formulation MG2 showed promising results, with maximum drug release (94.32%) and maximum drug release (94.32%). Conclusion: According to this report, transferosomes are a promising long-term delivery mechanism for metronidazole and have reasonably good stability.This study suggests that transferosomes containing Metronidazole may be used as a transdermal drug delivery tool for fungal skin infections.

Formulation and Ex vivo Permeation Study of Tamoxifen Citrate Loaded Transfersomal Gel

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My previous research covered factors, including preformulation studies, entrapment effectiveness, drug content, particle size, zeta potential, invitro drug release, and release kinetics. [10][11][12]

Ex-vivo Skin Penetration StudyA Franz diffusion cell, with a 15.0 mL receptor compartment capacity and a 2.54 cm 2 diffusion area was used for the ABSTRACT Objective: The current study's objective is to assess the transfersomal gel, administration of tamoxifen citrate transdermally for Design of Experiments (DoE) Approach. Materials and Methods: Supramolecular clusters with extreme flexibility, known as transferosomes can penetrate untouched animal skin.

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“…My previous research covered factors, including preformulation studies, entrapment effectiveness, drug content, particle size, zeta potential, invitro drug release, and release kinetics. [10][11][12]…”