Formulation and Ex vivo Permeation Study of Tamoxifen Citrate Loaded Transfersomal Gel

Abstract

Objective: The current study’s objective is to assess the transfersomal gel, administration of tamoxifen citrate transdermally for DEPARTMENT OF Expenditure (DOE) Approach. Materials and Methods: Supramolecular clusters with extreme flexibility, known as transferosomes can penetrate untouched animal skin. The formulations were designed by Box-Behnken design (BBD). The ex-vivo skin permeation study of tamoxifen citrate-loaded transferosomal gel was compared with commercial gel and blank drug solution. A total of 100 mg of the maximal drug release (94.32%) from the tamoxifen citrate optimized transferosome formulation demonstrated excellent results. Conclusion: According to this study, the comparatively stable transferosomes represent a promising long-term administration strategy for tamoxifen citrate. According to this study, transdermal drug delivery of skin cancer could be treated by employing transferosomes containing the tamoxifen citrate.

Formulation and Evaluation of Lipid-based Nanoformulation of Itraconazole

“…Analysis of the substance's chemical composition is greatly enhanced by the typical peaks seen in the 200 to 400 nm range at pH 7.4, as revealed by UV-visible spectra. 15,16 Using a 60:40 saline phosphate buffer solution (pH 7.4), the itraconazole calibration curve displayed a strong linearity (Y = 0.019x + 0.036) and an outstanding correlation coefficient (R² = 0.998). An extra linear curve emerged in a 60:40 phosphate buffer and methanol mixture at a pH of 6.8 (Y = 0.003x + 0.0078, R2 = 0.997).…”