Pharmaceutical care of adolescents with diabetes mellitus type 1: the DIADEMA study, a randomized controlled trial

Obarčanin, Emina; Krüger, Manfred; Müller, P; Nemitz, Verena; Schwender, Holger; Hasanbegović, Sniježana; Kalajdzisalihovic, Sena; Läer, Stephanie

doi:10.1007/s11096-015-0122-3

Cited by 22 publications

(19 citation statements)

References 35 publications

(36 reference statements)

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“…[13][14][15][16][17] The remaining 11 studies that had A1C values as a primary outcome were selected to be appropriate for the meta-analysis. [18][19][20][21][22][23][24][25][26][27][28] Further Analysis Procedure…”

Section: Systematic Review Resultsmentioning

confidence: 99%

Effective Interventions for Diabetes Patients by Community Pharmacists: A Meta-analysis of Pharmaceutical Care Components

et al. 2017

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Our meta-analysis suggests that community pharmacist-led interventions can improve glycemic control in patients with type 1 and 2 diabetes. The most effective intervention components were patient centered and interdisciplinary. Pharmaceutical care interventions should, therefore, include the following components: sending feedback to the physician, setting individual goals, reviewing medication, and assessing patients' health beliefs and medication knowledge.

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Section: Systematic Review Resultsmentioning

confidence: 99%

Effective Interventions for Diabetes Patients by Community Pharmacists: A Meta-analysis of Pharmaceutical Care Components

et al. 2017

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“…In this study the mean HbA1c level significantly decreased (0.83%) after six months in the intervention group compared with an increase of 0.43% in the control group (p ≤ 0.001) [29]. The DIabetes in ADolescence Engagement and Monitoring by pharmacists (DIADEMA) study, conducted simultaneously in Bosnia and Herzegovina and Germany, also lead to similar conclusions -the improvement in HbA1c levels was significantly greater in the intervention group vs. the control group at six months (change from baseline -0.54 vs. +0.32%, p = 0.0075) [30]. The extraordinary usefulness of pharmaceutical care in the geriatric population diagnosed with type 2 diabetes and hypertension was shown in the study performed by Brazilian Neto et al [31], where the length of follow-up was 36-months.…”

Section: Pharmaceutical Care Of Cardiology Patientsmentioning

confidence: 71%

The role of the pharmacist in the care of patients with cardiovascular diseases

et al. 2016

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“…With this empow-erment patients achieved better glycemic control mea-sured by lower HbA1c-values (1). Better glycemic control can minimise the risk of short-and long-term diabetes related complications such as retinopathy or blindness.…”

Section: Resultsmentioning

confidence: 97%

PP-8 Transition instead of transfer for drug treatment in adolescent diabetes type 1

2017

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BackgroundDiabetes mellitus is one of the most com-mon diseases in childhood and the incidence increased over the past 20 years about 3%–4%. Micro-and macrovas-cular complications, due to poor metabolic control, can lead to long-term complications such as high blood pres-sure. Especially in adolescence lower medication adher-ence is a huge risk for complications. The DIADEMA study, a randomised controlled trial, has shown that community pharmacists can have a positive impact on therapy ad-justment and glycemic control of adolescent diabetes patients The objective of this analysis was to understand how the intervention provided by the community phar-macist can help to support transition of the adolescent into adulthood regarding drug treatment.MethodA quantitative, statistical analysis of the 39 inter-vention group patients case-report-forms was conduct-ed, to evaluate the impact of community pharmacists on the different outcomes e.g. fasting blood glucose levels. A Wilcoxon-signed-rank test or fisher-extact test were used to evaluate the difference in the amount of self-moni-toring of blood glucose (SMBG), daily insulin injections, average fasting blood glucose levels, insulintherapy ad-herence, daily insulin dose and number of patients, which are following their nutrition plan or doing exercise or hav-ing hypoglycemic episodes. Inconsistent and imprecise data were excluded from the statistical analysis. Missing data was marked with n.a. and before the analysis was conducted a significance level of alpha=0.05 was set.ResultsThe statistical analysis revealed that pharma-ceutical care provided by community pharmacists can support transition of the adolescent regarding drug treatment becasue it resulted in more frequent SMBG, a greater amount of patients complying to their individual nutrition plan and injecting the correct insulin dose. Ad-ditionally, the insulintherapy adherence increased and resulted in lower fasting blood glucose levels. However, all these changes did not lead to an increase of hypogly-cemic episodes.ConclusionThe DIADEMA study demonstrated that ad-olescent diabetes patients benefit from the community pharmacists´approach to guide transition of drug treat-ment into a self responsible behaviour. With this empow-erment patients achieved better glycemic control mea-sured by lower HbA1c-values (1). Better glycemic control can minimise the risk of short-and long-term diabetes related complications such as retinopathy or blindness.

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Pharmaceutical care of adolescents with diabetes mellitus type 1: the DIADEMA study, a randomized controlled trial

Abstract: This study suggests that multidisciplinary PhC may add value in the management of T1DM in adolescents with inadequate glycemic control. However, the optimal methods on how to achieve sustained, long-term improvements in this challenging population require further study.

Cited by 22 publications

References 35 publications

Effective Interventions for Diabetes Patients by Community Pharmacists: A Meta-analysis of Pharmaceutical Care Components

Effective Interventions for Diabetes Patients by Community Pharmacists: A Meta-analysis of Pharmaceutical Care Components

The role of the pharmacist in the care of patients with cardiovascular diseases

PP-8 Transition instead of transfer for drug treatment in adolescent diabetes type 1

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