Pharmaceutical and biological properties of Stachys species: A review

Kanjevac, Milica; Zlatić, Nenad; Bojović, Biljana; Stanković, Milan

doi:10.1590/s2175-97902022e20211

Cited by 2 publications

(4 citation statements)

References 59 publications

(50 reference statements)

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“…As a member of the Lamiaceae family, the Stachys L. genus (wound plants) has garnered scientific interest regarding its chemical composition and therapeutic properties. In fact, numerous species of this genus have been used empirically in different regions of the world for their medicinal and economic potential since ancient times [1,2].…”

Section: Introductionmentioning

confidence: 99%

Stachys Species: Comparative Evaluation of Phenolic Profile and Antimicrobial and Antioxidant Potential

Benedec,

Oniga,

Hanganu

et al. 2023

Antibiotics

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This study aimed to investigate the polyphenolic composition and antioxidant and antimicrobial potential of six Romanian Stachys species: S. officinalis, S. germanica, S. byzantina, S. sylvatica, S. palustris, and S. recta. The LC-MS/MS method was used to analyze the polyphenolic profile, while the phenolic contents were spectrophotometrically determined. The antioxidant activity was evaluated using the following methods: DPPH, FRAP, nitrite-induced autooxidation of hemoglobin, inhibition of cytochrome c-catalyzed lipid peroxidation, and electron paramagnetic resonance spectroscopy. The in vitro antimicrobial properties were assessed using agar-well diffusion, broth microdilution, and antibiofilm assays. Fifteen polyphenols were identified using LC-MS and chlorogenic acid was the major component in all the samples (1131.8–6761.4 μg/g). S. germanica, S. palustris, and S. byzantina extracts each displayed an intense antiradical action in relation to high contents of TPC (6.40 mg GAE/mL), flavonoids (3.90 mg RE/mL), and caffeic acid derivatives (0.89 mg CAE/mL). In vitro antimicrobial and antibiofilm properties were exhibited towards Candida albicans, Gram-positive and Gram-negative strains, with the most intense efficacy recorded for S. germanica and S. byzantina when tested against S. aureus. These results highlighted Stachys extracts as rich sources of bioactive compounds with promising antioxidant and antimicrobial efficacies and important perspectives for developing phytopharmaceuticals.

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Section: Introductionmentioning

confidence: 99%

Stachys Species: Comparative Evaluation of Phenolic Profile and Antimicrobial and Antioxidant Potential

Benedec,

Oniga,

Hanganu

et al. 2023

Antibiotics

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“…Additionally, quantitative analysis revealed that S. sylvatica L. collected in Kazakhstan is rich in numerous chlorogenic acid derivatives, e.g., isochlorogenic acid or cryptochlorogenic acid, rarely reported in samples collected in other parts of the world (Benedec et al, 2023;Di Stasi et al, 2023). However, it is worth mentioning that chlorogenic acid derivatives were reported in research including other Stachys species, e.g., isochlorogenic acid was found in S. officinalis L. (Vundać et al, 2005;Kanjevac et al, 2023), while neochlorogenic and cryptochlorogenic acids in S. palustris L. (Kartsev et al, 1994). Similarly, we detected multiple luteolin derivatives, which were not detected in other studies concerning S. sylvatica L. (Benedec et al, 2023;Di Stasi et al, 2023).…”

Section: Discussionmentioning

confidence: 98%

“…The leaves are responsible for the plant’s unpleasant smell ( Alizadeh et al, 2020 ). Plants from the Stachys L. genus can be found in both hemispheres, including the Mediterranean Region, southwest Asia as well as in South and North America and North Africa, except for New Zeland and Australia ( Tunçtürk et al, 2019 ; Güner et al, 2021 ; Kanjevac et al, 2023 ). S. sylvatica L. growth area in Kazakhstan includes Altai, Tarbagatai, the Dzungarian Alatau and the ridges of the Northern Tian Shan: Zailiysky, Kungei, Terskei Alatau and Ketmen.…”

Section: Introductionmentioning

confidence: 99%

“…Plants belonging to the Stachys L. genus constitute a rich source of diverse metabolites exhibiting a wide spectrum of biological activity: antioxidant ( Kukić et al, 2006 ; Jassbi et al, 2014 ; Tundis et al, 2015 ), anticancer ( Foruzani et al, 2015 ; Barmoudeh et al, 2022 ; Slimani et al, 2023 ) and antimicrobial ( Saeedi et al, 2008 ; Koutsaviti et al, 2011 ; Lazarević et al, 2013 ; Gizem et al, 2021 ). The chemical composition of Stachys species varies and depends strongly on the type of plant habitat and geographical location, the availability of water and nutrients or the stage of plant development ( Kanjevac et al, 2023 ). Among the most biologically active secondary metabolites, there are polyphenols, iridoids, terpenoids, fatty acids, alkaloids, triterpenes and many others, represented by more than 200 metabolites ( Bilušić, 2019 ; Tomou et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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Anthelminthic and antimicrobial effects of hedge woundwort (Stachys sylvatica L.) growing in Southern Kazakhstan

Mukhamedsadykova,

Kasela,

Kozhanova

et al. 2024

Front. Pharmacol.

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The Stachys L. genus has been widely used in traditional medicine in many countries throughout the world. The study aimed to investigate the chemical composition and bioactivity of the hydroethanolic extract (50% v/v) obtained by ultrasonication from the aerial flowering parts of Stachys sylvatica L. (SSE) collected in Almaty region (Southern Kazakhstan). According to RP-HPLC/PDA analysis the leading metabolites of the SSE belonged to polyphenols: chlorogenic acid and its isomers (2.34 mg/g dry extract) and luteolin derivatives (1.49 mg/g dry extract), while HPLC-ESI-QTOF-MS/MS-based qualitative fingerprinting revealed the presence of 17 metabolites, mainly chlorogenic acid and its isomers, flavonoid glycosides, and verbascoside with its derivatives. GC-MS analysis of the volatile metabolites showed mainly the presence of diterpenoids and fatty acid esters. A reduction in the viability of nematodes Rhabditis sp. was obtained for the SSE concentration of 3.3 mg/mL, while 11.1 mg/mL showed activity comparable to albendazole. The SSE exhibited higher activity against Gram-positive (MIC = 0.5–2 mg/mL) than Gram-negative bacteria and yeast (MIC = 8 mg/mL), exerting bactericidal and fungicidal effects but with no sporicidal activity. The SSE showed some antiviral activity against HCoV-229E replicating in MRC-5 and good protection against the cytopathic effect induced by HHV-1 in VERO. The SSE was moderately cytotoxic towards human cervical adenocarcinoma (H1HeLa) cells (CC50 of 0.127 mg/mL after 72 h). This study provides novel information on the SSE extract composition and its biological activity, especially in the context of the SSE as a promising candidate for further antiparasitic studies.

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Pharmaceutical and biological properties of Stachys species: A review

Cited by 2 publications

References 59 publications

Stachys Species: Comparative Evaluation of Phenolic Profile and Antimicrobial and Antioxidant Potential

Stachys Species: Comparative Evaluation of Phenolic Profile and Antimicrobial and Antioxidant Potential

Anthelminthic and antimicrobial effects of hedge woundwort (Stachys sylvatica L.) growing in Southern Kazakhstan

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