1975
DOI: 10.1515/znc-1975-11-1217
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Phalloidin-Induced Proliferation of Actin Filaments within Rat Hepatocytes

Abstract: Confirming our previous ultrastructural and biochemical studies, the combined electron microscopy and immunofluorescence investigations show that phalloidin causes a characteristically striking increase of actin filaments within rat hepatocytes. Filaments are localized mainly at the level of special junctional complexes between contiguous cells and around bile canaliculi.

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Cited by 21 publications
(2 citation statements)
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“…It binds to actin molecules in actin filaments and stabilizes the filaments (123) under a variety of conditions where actin filaments usually depolymerize, including exposure to DNase I (124), 0.6 M KI (125), OS04 (126), ultrasonication (125), and high temperature (127). This stabilization probably accounts for the abundance of actin filaments in electron micrographs of phalloidin-treated cells (128) . Although phalloidin does not readily enter cells, it can be microinjected (129) .…”
Section: Drugs That Act On Cytoplasmic Contractile Proteinsmentioning
confidence: 99%
“…It binds to actin molecules in actin filaments and stabilizes the filaments (123) under a variety of conditions where actin filaments usually depolymerize, including exposure to DNase I (124), 0.6 M KI (125), OS04 (126), ultrasonication (125), and high temperature (127). This stabilization probably accounts for the abundance of actin filaments in electron micrographs of phalloidin-treated cells (128) . Although phalloidin does not readily enter cells, it can be microinjected (129) .…”
Section: Drugs That Act On Cytoplasmic Contractile Proteinsmentioning
confidence: 99%
“…Phalloidin, a toxin which acts on cytoplasmic microfilaments in liver parenchymal cells (Govindan et al, 1972;Agostini et al, 1975), induces in the isolated perfused rat liver potassium loss (Frimmer et al, 1967) and endocytotic fluid uptake . To the present it is unknown whether these two phenomena are interdependent or discrete events.…”
Section: Introductionmentioning
confidence: 99%