Differential effect of raised Mg2+ concentration on K+ ion movement and on swelling in the isolated perfused rat liver poisoned by phalloidin

Abstract

The K+ release from the isolated perfused rat liver induced by phalloidin was strongly inhibited on raising the Mg2+ concentration of the perfusion medium from 0.5-40mM while, in contrast, the phalloidin induced swelling of the organ and the vasuolisation of the liver tissue was not affected.