Phakomatous choristoma of the eyelid

Dithmar, Stefan; Schmack, Ingo; Völcker, H. E.; Grossniklaus, Hans E.

doi:10.1007/s00417-003-0743-4

Cited by 15 publications

(9 citation statements)

References 16 publications

(16 reference statements)

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“…25 The natural history of phakomatous choristoma is not known. 6 In some of the previously reported cases, the mass had remained unchanged in size since birth, 9,11,12,14–16,18,22 whereas in several others gradual increase in the size of the lesion had been recorded. 1,2,4–6,8,10,17,23,24…”

Section: Discussionmentioning

confidence: 90%

“…1–24 The site of the lesion has been either the eyelids or the anterior orbit. 1–24 However, there has been one instance of its occurrence in the corneal stroma. 25 The natural history of phakomatous choristoma is not known.…”

Section: Discussionmentioning

confidence: 99%

“…1 By present, 26 cases of this extremely rare tumor have been reported in the literature. 1–24 With the exception of one case from Turkey, 21 there are no other reports from the Middle East countries. Herein, we present a case of phakomatous choristoma in an infant from Iran.…”

Section: Introductionmentioning

confidence: 99%

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Phakomatous Choristoma of the Eyelid and Orbit: A Case Report

2019

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Phakomatous choristoma was first described as a distinct pathologic entity by Zimmerman in 1971. Report of only 26 cases of this tumor so far is an indicator of the rarity of phakomatous choristoma. We present a 4-month-old infant with an orbital mass beneath the right lower eyelid. Surgical excision was undertaken and the histopathologic findings of a dense fibrocollagenous stroma containing small to medium size islands and glandular-like structures surrounded by thick basement membrane and filled by amorphous eosinophilic material confirmed the diagnosis. Immunohistochemical study showed positive staining for S-100 and vimentin and negative staining for cytokeratins, glial fibrillary acidic protein, smooth muscle actin, synaptophysin, CD34, melan-A, and epithelial membrane antigen markers. This is the first patient with phakomatous choristoma presented from our country and the 27th reported case worldwide. Phakomatous choristoma is a rare, benign congenital tumor of lenticular anlage, almost always presenting in the medial lower eyelid and anterior orbit. Surgical excision is curative and allows precise diagnosis due to the unique histopathologic and immunostaining characteristics of this choristoma.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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Phakomatous Choristoma of the Eyelid and Orbit: A Case Report

2019

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“…One child was followed for 7.5 years and the other for approximately 16 months, without evidence of recurrence or residual tumor. [ 6 ] Because choristoma is classified as a benign tumor, many studies do not discuss recurrence. The case reported in this study showed benign tumor characteristics based on the preoperative MRI findings and the intraoperative observations.…”

Section: Discussionmentioning

confidence: 99%

“…Kurman et al [6] Seyed et al [7] GW P et al [8] A T-E et al [10] R S, et al [9] Chen et al [11] PF C, et al [1] M S, et al [17] M Z, et al [13] JC M-H, et al [12] G R [15] Y L et al [14] YW H, et al [17] Pan-CKs adjacent coverings of vessels and neural structures. [26] As no clear cleavage plane is found between the intraspinal lipoma and spinal cord, very few reports recommend complete surgical removal of an intraspinal lipoma as complete resection is associated with significant postoperative complications.…”

Section: Referencementioning

confidence: 99%

Intraspinal choristoma in the lumbar region: A case report

Yang¹,

Liang²,

Wang³

et al. 2022

Medicine

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Rationale: Intraspinal choristoma is a relatively uncommon intervertebral canal tumor. Prior to our reports, only 2 cases of intraspinal choristoma had been reported. Because this disease is not common and looks like a mass of fatty tissue on the magnetic resonance imaging (MRI), intraspinal choristoma can be easily misdiagnosed as teratomas or lipomas (like the case of this article presenting) without a pathology report. So if a lumber intraspinal lesion is discovered in a clinical examination, intraspinal choristoma should be considered as a differential diagnosis. We present a case of intraspinal choristoma that is unlike any other reported case. Patient concerns: A 35-year-old woman with left lower extremity hypoesthesia and burning-like pain in the lumbar region for 1 month visited the local hospital for plain lumbar spine MRI. The patient was diagnosed with a lumbar space-occupying lesion. A second plain lumbar spine MRI scan and a MRI scan with enhancement were performed in our hospital to confirm the presence of a congenital lipoma in the spinal canal. A postoperative biopsy of the lumbar spinal mass indicated that the mass was an intraspinal choristoma located in the spinal canal. Diagnosis: Intraspinal choristoma. Intervention: The lesion was surgically removed, and follow-up plain and enhanced MRI images of the patient’s lumbar spine were obtained. Outcomes: After surgery, the patient no longer experienced the burning pain in her lumbar region or the left lower extremity hypoesthesia when the patient was discharged. And there was no evidence of recurrence 2 years after the surgery. Lessons: The MRI presentation of intraspinal choristoma is similar to intraspinal lipoma. Therefore, a pathological assessment is critical to provide an accurate diagnosis.

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Biopsy of the Eyelid, the Lacrimal Sac, and the Temporal Artery

Roberts

Thum

2013

Lee's Ophthalmic Histopathology

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Phakomatous choristoma of the eyelid

Cited by 15 publications

References 16 publications

Phakomatous Choristoma of the Eyelid and Orbit: A Case Report

Phakomatous Choristoma of the Eyelid and Orbit: A Case Report

Intraspinal choristoma in the lumbar region: A case report

Biopsy of the Eyelid, the Lacrimal Sac, and the Temporal Artery

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