Phagocytosis, Oxidative Burst, and Produced Reactive Species are Affected by Iron Deficiency Anemia and Anemia of Chronic Diseases in Elderly

Paino, Iêda Maria Martinez; Miranda, Julise Cunha; Marzocchi-Machado, Cleni Mara; Cesarino, Evandro José; Castro, Fabíola Attié de; Souza, Ana Maria de

doi:10.1007/s12011-008-8303-8

Cited by 20 publications

(23 citation statements)

References 22 publications

(28 reference statements)

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“…[1] The significantly increased absolute neutrophil count in anemic patients in the present study could possibly be due to compensatory activity due to inhibition in the capability to phagocytose. [2][3][4][5][6] In the present study, significant lymphopenia in anemic group is well correlated with some studies done in the past. The lymphopenia could be due to reduction in the lifespan of lymphocytes secondary to oxidative damage.…”

Section: Discussionsupporting

confidence: 85%

Association of nutritional anemia with leukocyte and platelet counts in people of Odisha

Samanta¹,

Senapati²

2017

Natl J Physiol Pharm Pharmacol

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Background: Anemia is the most common hematological disorder in the world, due to deficiency of micronutrients such as iron, Zn, Se, Cu, folic acid, and vitamins. Iron deficiency impairs immune response and bactericidal activity of macrophages, monocytes, and neutrophils that alters the length and quality of life. Leukocyte count may be altered due to hypoxia and ischemia, which is seen in anemia. A strong association between leukocyte counts and ischemia is seen from the experimental and clinical studies. Aims and Objectives: The present study was aimed to estimate total leukocyte count (TLC) and differential leukocyte count (DLC), neutrophil-to-lymphocyte ratio (N/L ratio), and platelet count in anemia. N/L ratio has emerged as a useful index in ischemic heart disease (IHD). Materials and Methods: A total of 30 patients of nutritional anemia in both the sexes were taken as study group, whose hemoglobin level was <6 g%, and they were compared with 30 healthy subjects of same age group. The parameters studied were TLC, DLC, N/L ratio, and platelet count. Results: TLC is insignificantly higher in anemic subjects. DLC shows, significant rise in absolute neutrophil count (P < 0.005), fall in absolute lymphocyte count significantly (P < 0.005), and rise in eosinophil and basophil count which is not statistically significant. There is not much difference in monocyte count in both groups. Associated poikilocytosis and anisocytosis of red blood cells are present in anemic subjects. N/L ratio is significantly higher in anemics (P < 0.001). Platelet count is decreased significantly in patients of anemia than control subjects (P < 0.001). Conclusions: Thus, our study highlights that, immunity especially cellular immunity, is influenced by nutritional anemia. High N/L ratio in anemia is associated with IHD and severe anemia is also associated with thrombocytopenia.

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Section: Discussionsupporting

confidence: 85%

Association of nutritional anemia with leukocyte and platelet counts in people of Odisha

Samanta¹,

Senapati²

2017

Natl J Physiol Pharm Pharmacol

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“…Since the AgNp toxicity appears to be induced by their oxidative mechanisms, the ROS generation may be the major process involved in inflammation processes causing deleterious effects. It has been reported that upon activation, neutrophils may increase oxidative burst provoking inflammatory or rheumatic diseases in human (Paino et al, 2009). In addition, it has been reported that enhanced respiratory burst of neutrophils through DCFH oxidation also occurs in patients with infections (Bass et al, 1986;Burow and Valet, 1987).…”

Section: Discussionmentioning

confidence: 99%

“…All the participants gave informed written consent for ethical and legal procedures. PBMC and neutrophils were isolated by density gradient centrifugation on Histopaque ® 1077 and 1119 as described in Paino et al (2009). Neutrophils were found at bottom layer while PBMC at the plasma interphase.…”

Section: Isolation Of Pbmc and Neutrophilsmentioning

confidence: 99%

“…Its antimicrobial function occurs by releasing proteolytic enzymes and also by promoting the oxidative burst characterized by reactive oxygen species (ROS) generation (Clark, 1999). On the other hand, upon activation, the neutrophils also play an important role in inflammatory conditions involved in deleterious effects in chronic inflammation diseases due to the excessive ROS production (Paino et al, 2009). Furthermore, the direct activation of neutrophils by a nanoparticle or its capacity to activate the oxidative burst is still poorly understood, or it has not been reported in the literature in human neutrophils by AgNps-PVA.…”

Section: Introductionmentioning

confidence: 99%

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Poly(vinyl alcohol)-coated silver nanoparticles: Activation of neutrophils and nanotoxicology effects in human hepatocarcinoma and mononuclear cells

Paino

Zucolotto

2015

Environmental Toxicology and Pharmacology

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“…NADPH oxidase contains two haem groups that play a central role in catalysing oxygen (O 2 ) to the ROS superoxide anion (O 2 •À ), a free radical that is used to help kill invading microorganisms, either directly or through its subsequent conversion to hydrogen peroxide and hypochlorous acid. Iron deficiency is associated with reduced activity of NADPH oxidase and a reduced ability to produce hypochlorous acid, whilst NADPH oxidase activity can be restored by iron supplementation (Kurtoglu et al, 2003;Paino et al, 2009). Reactive oxygen species can also have damaging effects.…”

Section: Iron Functions and Oxidative Stressmentioning

confidence: 99%

Safety and benefits of antenatal oral iron supplementation in low‐income countries: a review

2017

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SummaryThe World Health Organization recommends universal iron supplementation of 30–60 mg/day in pregnancy but coverage is low in most countries. Its efficacy is uncertain, however, and there has been a vigorous debate in the last decade about its safety, particularly in areas with a high burden of malaria and other infectious diseases. We reviewed the evidence on the safety and efficacy of antenatal iron supplementation in low‐income countries. We found no evidence that daily supplementation at a dose of 60 mg leads to increased maternal Plasmodium infection risk. On the other hand, recent meta‐analyses found that antenatal iron supplementation provides benefits for maternal health (severe anaemia at postpartum, blood transfusion). For neonates, there was a reduced prematurity risk, and only a small or no effect on birth weight. A recent trial showed, however, that benefits of antenatal iron supplementation on maternal and neonatal health vary by maternal iron status, with substantial benefits in iron‐deficient women. The benefits of universal iron supplementation are likely to vary with the prevalence of iron deficiency. As a consequence, the balance between benefits and risks is probably more favourable in low‐income countries than in high‐income countries despite the higher exposure to infectious pathogens.

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Phagocytosis, Oxidative Burst, and Produced Reactive Species are Affected by Iron Deficiency Anemia and Anemia of Chronic Diseases in Elderly

Cited by 20 publications

References 22 publications

Association of nutritional anemia with leukocyte and platelet counts in people of Odisha

Association of nutritional anemia with leukocyte and platelet counts in people of Odisha

Poly(vinyl alcohol)-coated silver nanoparticles: Activation of neutrophils and nanotoxicology effects in human hepatocarcinoma and mononuclear cells

Safety and benefits of antenatal oral iron supplementation in low‐income countries: a review

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