Phagocytosis of ultrasound contrast agent microbubbles by Kupffer cells

Yanagisawa, Kyosuke; Moriyasu, Fuminori; Miyahara, Takeo; Miyata, Yuki; Iijima, Hiroko

doi:10.1016/j.ultrasmedbio.2006.08.008

Cited by 307 publications

(292 citation statements)

References 21 publications

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“…Kupffer cells phagocytize a high percentage of Sonazoid, and the result is a delayed parenchymal phase that starts about 10 min after injection. In this phase, lesions that do not contain Kupffer cells, such as HCC or metastases, are depicted as contrast defects surrounded by enhanced normal hepatic parenchyma [18].…”

Section: Discussionmentioning

confidence: 99%

Contrast enhanced ultrasound: Roles in immediate post-procedural and 24-h evaluation of the effectiveness of thermal ablation of liver tumors

Meloni

Andreano

Zimbaro

et al. 2012

Journal of Ultrasound

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KEYWORDSContrast-enhanced ultrasound; Ultrasonography; Interventional; Ablation techniques; Sensitivity and specificity.Abstract Purpose: To retrospectively assess the diagnostic accuracy of immediate postprocedural CEUS, 24-h CEUS, and 24-h CT in verifying the effectiveness of thermal ablation of liver tumors ablation, using the combined results of 3-month post-procedure CEUS and MDCT as the reference standard. Materials and methods: From our database, we selected patients who had immediate postprocedural CEUS and 24-h CEUS and MDCT examinations after undergoing thermal ablation of a liver tumor between January 2009 and March 2010. The study population consisted of 53 subjects and 55 tumors (44 HCC and 11 metastasis) were evaluated. Thirty-seven tumors were treated with radiofrequency and 18 with microwave ablation. Post-procedural CEUS, 24-h CEUS and MDCT, and 3-month follow-up CEUS and MDCT images were blindly reviewed by two radiologists, who measured the size of the ablation area on the post-procedural and 24-h studies. They also evaluated the ability of each of these three index tests to predict the outcome (residual tumor vs. no residual tumor) using imaging studies done at the 3-month follow-up as the reference standard. Results: Mean tumor diameter on preablation CEUS (the day before treatment) was 20 AE 9 mm. Mean diameter of the necrotic area was 29 AE 9 mm on post-procedural CEUS, 34 AE 11 mm on 24-h CEUS, and 36 AE 11 mm on 24-h MDCT. Diameters of the necrotic area (mean and maximum) on post-procedural CEUS were significantly smaller than those measured on 24-h CEUS or 24-h MDCT, which were not significantly different. For predicting the presence of residual tumor at the 3-month follow-up, post-procedural CEUS, 24-h CEUS, and 24-h MDCT displayed sensitivity of 33%, 33%, and 42%; specificity of 92%, 97%, and 97%; negative predictive value of 84%, 85%, and 83%. The accuracy parameters of these three imaging modalities were * SIUMB Award for the Best Poster at the National SIUMB Congress 2010. Sommario Scopo: Determinare retrospettivamente l'accuratezza diagnostica nella valutazione di efficacia delle ablazioni di tumori epatici della CEUS eseguita al termine della procedura ablativa, della CEUS e della la tomografia computerizzata multi-detettore (TCMD) eseguite a 24 ore, utilizzando la CEUS e TCMD a 3 mesi di follow-up come standard di riferimento. Materiali e metodi: Abbiamo selezionato dal nostro data base i pazienti sottoposti a CEUS subito dopo una procedura di ablazione e a CEUS e TCMD dopo 24 ore tra gennaio 2009 e marzo 2010. Il campione era composto da 53 soggetti in cui abbiamo valutato 55 lesioni (44 HCC e 11 metastasi). Trentasette lesioni sono state trattate con ablazione a radiofrequenza, 18 mediante microonde. La CEUS post-trattamento, la CEUS e la TCMD eseguite a 24 ore, e la CEUS e la TCMD eseguite a tre mesi di follow-up sono state rivalutate in cieco da due radiologi. Abbiamo confrontato tra loro le dimensioni della termoablazione misurate alla CEUS postprocedura, alla CEUS e alla T...

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Section: Discussionmentioning

confidence: 99%

Contrast enhanced ultrasound: Roles in immediate post-procedural and 24-h evaluation of the effectiveness of thermal ablation of liver tumors

Meloni

Andreano

Zimbaro

et al. 2012

Journal of Ultrasound

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“…These contrast agents provide detailed perfusion features of the microvascular bed of the liver parenchyma and tumor during the vascular phase. Moreover, Kupffer imaging in the postvascular phase, which is stable for at least 3 h after injection and tolerable for multiple scanning, can be obtained in the low-power acoustic field because Sonazoid microbubbles are phagocytosed by Kupffer cells [187].…”

Section: Combination Of Tumor Markersmentioning

confidence: 99%

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

et al. 2010

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Introduction The Asian Pacific Association for the Study of the Liver (APASL) convened an international working party on the management of hepatocellular carcinoma (HCC) in December 2008 to develop consensus recommendations. Methods The working party consisted of expert hepatologist, hepatobiliary surgeon, radiologist, and oncologist from Asian-Pacific region, who were requested to make drafts prior to the consensus meeting held at Bali, Indonesia on 4 December 2008. The quality of existing evidence and strength of recommendations were ranked from 1 (highest) to 5 (lowest) and from A (strongest) to D (weakest), respectively, according to the Oxford system of evidence-based approach for developing the consensus statements. 123Hepatol Int (2010) 4: 439-474 DOI 10.1007/s12072-010-9165-7 Results Participants of the consensus meeting assessed the quality of cited studies and assigned grades to the recommendation statements. Finalized recommendations were presented at the fourth APASL single topic conference on viral-related HCC at Bali, Indonesia and approved by the participants of the conference.

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“…Microbubbles have a purely intravascular distribution even though some agents present a post-vascular hepato-and/or spleno-specific phase beginning 5 min after i.v. injection and lasting from 15 min up to 1 h after injection [11,12]. The microbubble gas content is exhaled via the lungs 10 to 15 min after injection while the components of the shell are metabolised by the liver or filtered by the kidney.…”

Section: Introductionmentioning

confidence: 99%