Phagocytosis of injured hepatocytes following inoculation with encephalomyocarditis virus

Harb, Joseph M.; Hiramoto, Y.; Burch, George E.

doi:10.1016/0014-4800(74)90054-9

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…However, the urinary tract symptoms also could be consistent with EMCV infection because orchitis has been observed in male laboratory male mice and hamsters (30,31). Hyperbilirubinemia, associated with EMCV infection in humans, is consistent with the observation of liver compromise that has been well documented in laboratory studies of EMCV-infected mice, swine, and primates (5,32). The 2 case-patients probably had contact with infected animals.…”

Section: Discussionsupporting

confidence: 57%

Human Febrile Illness Caused by Encephalomyocarditis Virus Infection, Peru

Oberste¹,

Gotuzzo

Blair

et al. 2009

Emerg. Infect. Dis.

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Etiologic studies of acute febrile disease were conducted in sites across South America, including Cusco and Iquitos, Peru. Patients' clinical signs and symptoms were recorded, and acute-and convalescent-phase serum samples were obtained for serologic examination and virus isolation in Vero E6 and C6/36 cells. Virus isolated in Vero E6 cells was identifi ed as encephalomyocarditis virus (EMCV) by electron microscopy and by subsequent molecular diagnostic testing of samples from 2 febrile patients with nausea, headache, and dyspnea. The virus was recovered from acute-phase serum samples from both case-patients and identifi ed with cardiovirus-specifi c reverse transcription-PCR and sequencing. Serum samples from case-patient 1 showed cardiovirus antibody by immunoglobulin M ELISA (acute phase <8, convalescent phase >1,024) and by neutralization assay (acute phase <10, convalescent phase >1,280). Serum samples from case-patient 2 did not contain antibodies detectable by either assay. Detection of virus in serum strongly supports a role for EMCV in human infection and febrile illness.

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Section: Discussionsupporting

confidence: 57%