Phagocytic labeling of leukocytes with 99mTc-albumin colloid for nuclear imaging

Marcus, Carol S.; Kuperus, John; Butler, John; Henneman, Philip L.; Salk, Robert D.; Chen, Bi-Ying; Vivian, Michael R.P.; Yamanaka, L. M.

doi:10.1016/0883-2897(88)90060-8

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…A number of particulate agents such as 99m Tc-sulfur colloid, -phytate, -albumin milimicrospheres, -SnO colloid, -poly(lactic acid) (PLA) particles, 111 In-Fe colloid, -bleomycin liposomes, 198 Au colloid, and 76 As-microdiscs of polycrystalline SiO 2 have been tested to label neutrophils and monocytes [30,[49][50][51][52][53]. Either the isolated cells or the whole blood is incubated with radiocolloids for 1-2 h for incorporation into leukocytes.…”

Section: Radiocolloids (Phagocytic Labelling)mentioning

confidence: 99%

Radiopharmaceuticals for the Visualization of Infectious and Inflammatory Lesions

Ercan¹,

Kostakoğlu²

2000

CPD

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Many radiopharmaceuticals have been introduced for the scintigraphic demonstration of infectious and inflammatory lesions and some of them are currently in clinical use. They can be classified into two major categories according to their specificity. Specific radiopharmaceuticals include in vitro labeled leukocytes, radio-labelled monoclonal antibodies, and receptor specific small proteins and peptides. Nonspecific radiopharmaceuticals include radiolabelled nanocolloids, liposomes, macromolecules such as human immunoglobulin, dextran and human serum albumin, various small molecules and ions. In this review article radiopharmaceuticals in their respective groups are discussed as to the efficacy, and other parameters such as the physical characteristics of the radionuclides used, radiochemistry involved, availability, cost and biodistribution, emphasizing recent developments.

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