Non-radioactive and sensitive tracking of neutrophils towards inflammation using antibody functionalized magnetic particle imaging tracers

Chandrasekharan, Prashant; Fung, K. L. Barry; Cui, Weiwen; Colson, Caylin; Mai, David; Jeffris, Kenneth E; Huynh, Quincy; Saayujya, Chinmoy; Kabuli, Leyla; Fellows, Benjamin D.; Lu, Yao; Yu, Elaine; Tay, Zhi Wei; Zheng, Bo; Fong, Lawrence; Conolly, Steven M.

doi:10.7150/ntno.50721

Cited by 28 publications

(31 citation statements)

References 82 publications

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“…[ 50 , 51 ] Aptly named “Magnetic Particle Imaging of Macrophages Associated with Cancer: Filling the Voids Left by Iron-Based Magnetic Resonance Imaging.”, the study showcased how MPI’s positive contrast and quantitative nature complements the traditional MRI images of TAMs. In addition to this, MPI can also image inflammation by in situ labeling of inflammatory immune cells [ 52 ]. Although this study did not target cancer cells per se, the same in situ labeling concept could be used to image the inflammatory tumor microenvironment.…”

Section: Imaging Cancer Using Magnetic Particle Imagingmentioning

confidence: 99%

Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer

Tay

Chandrasekharan

Fellows

et al. 2021

Cancers

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Background: Magnetic Particle Imaging (MPI) is an emerging imaging modality for quantitative direct imaging of superparamagnetic iron oxide nanoparticles (SPION or SPIO). With different physics from MRI, MPI benefits from ideal image contrast with zero background tissue signal. This enables clear visualization of cancer with image characteristics similar to PET or SPECT, but using radiation-free magnetic nanoparticles instead, with infinite-duration reporter persistence in vivo. MPI for cancer imaging: demonstrated months of quantitative imaging of the cancer-related immune response with in situ SPION-labelling of immune cells (e.g., neutrophils, CAR T-cells). Because MPI suffers absolutely no susceptibility artifacts in the lung, immuno-MPI could soon provide completely noninvasive early-stage diagnosis and treatment monitoring of lung cancers. MPI for magnetic steering: MPI gradients are ~150 × stronger than MRI, enabling remote magnetic steering of magneto-aerosol, nanoparticles, and catheter tips, enhancing therapeutic delivery by magnetic means. MPI for precision therapy: gradients enable focusing of magnetic hyperthermia and magnetic-actuated drug release with up to 2 mm precision. The extent of drug release from the magnetic nanocarrier can be quantitatively monitored by MPI of SPION’s MPS spectral changes within the nanocarrier. Conclusion: MPI is a promising new magnetic modality spanning cancer imaging to guided-therapy.

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Section: Imaging Cancer Using Magnetic Particle Imagingmentioning

confidence: 99%

Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer

Tay

Chandrasekharan

Fellows

et al. 2021

Cancers

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“…228 Similar to generic cell tracking, there are two primary methods to monitor inflammation with SPIONs. 17 Either the nanoparticles are loaded directly into phagocytotic immune cells like macrophages ex vivo , with subsequent injection, or they are directly injected, to be engulfed by the cells in situ . Once tagged, these specific cells can be tracked as they migrate and accumulate within regions of localised inflammation.…”

Section: Primary Biomedical Applications Of Mpimentioning

confidence: 99%

“…Traditionally, tracking has been performed using WBCs directly labelled with radionuclides for scintigraphy or SPECT. 17 However, this is not ideal for general screening due to the extensive costs, tracer radioactivity, and high dosage of tracer required. In a very recent work, Chandrasekharan et al explored for the first time, MPI, for the sensitive and radiation-free tracking of WBCs to sites of inflammation and infection.…”

Section: Primary Biomedical Applications Of Mpimentioning

confidence: 99%

“…In a very recent work, Chandrasekharan et al explored for the first time, MPI, for the sensitive and radiation-free tracking of WBCs to sites of inflammation and infection. 17 For this, they used the commercially available antibody-conjugated multi-core anti-Ly6G SPION (Miltenyi Biotec GmBH, Fig. 15a) for in situ labelling and tracking, which is specific to the Ly6G antigen expressed on neutrophils.…”

Section: Primary Biomedical Applications Of Mpimentioning

confidence: 99%

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Magnetic particle imaging: tracer development and the biomedical applications of a radiation-free, sensitive, and quantitative imaging modality

2022

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“…Magnetic particle imaging (MPI) is a rapidly developing tracer-based medical imaging modality, which takes advantage of the non-linear response of magnetic nanoparticles (MNPs) under time-varying magnetic fields [1][2][3][4][5]. The leading applications of MPI include angiography [6,7], stem cell tracking [8][9][10], inflammation imaging [11,12], and localized hyperthemia [13]. Color MPI is an emerging field within MPI, providing a means to distinguish different MNPs and/or MNP environments [14].…”

Section: Introductionmentioning

confidence: 99%

Rapid TAURUS for Relaxation-Based Color Magnetic Particle Imaging

Arslan¹,

Ozaslan²,

Kurt³

et al. 2021

Preprint

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Magnetic particle imaging (MPI) is a rapidly developing medical imaging modality that exploits the non-linear response of magnetic nanoparticles (MNPs). Color MPI widens the functionality of MPI, empowering it with the capability to distinguish different MNPs and/or MNP environments. The system function approach for color MPI relies on extensive calibrations that capture the differences in the harmonic responses of the MNPs. An alternative calibration-free x-space-based method called TAURUS estimates a map of the relaxation time constant, τ , by recovering the underlying mirror symmetry in the MPI signal. However, TAURUS requires a back and forth scanning of a given region, restricting its usage to slow trajectories with constant or piecewise constant focus fields (FFs). In this work, we propose a novel technique to increase the performance of TAURUS and enable τ map estimation for rapid and multi-dimensional trajectories. The proposed technique is based on correcting the distortions on mirror symmetry induced by time-varying FFs. We demonstrate via simulations and experiments in our in-house MPI scanner that the proposed method successfully estimates high-fidelity τ maps for rapid trajectories that provide orders of magnitude reduction in scanning time, while preserving the calibration-free property of TAURUS.

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Non-radioactive and sensitive tracking of neutrophils towards inflammation using antibody functionalized magnetic particle imaging tracers

Cited by 28 publications

References 82 publications

Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer

Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer

Magnetic particle imaging: tracer development and the biomedical applications of a radiation-free, sensitive, and quantitative imaging modality

Rapid TAURUS for Relaxation-Based Color Magnetic Particle Imaging

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