Phagedaena Geometrica (Brocq)

Pyoderma gangrenosum: From historical perspectives to emerging investigations

“…Ultimately, PG has had many names, although pyoderma gangrenosum was adopted rapidly following Brunsting et al's description (Table 1). 9,21 By the 1940s, it was accepted that PG most often occurred in association with UC, but was also thought to occur with trauma, infectious arthritis, upper respiratory infection, pleuritis, pericarditis, cholecystitis, genitourinary infections, abscessed tooth, or (rarely) independently 20,21 . The first example of PG with extracutaneous involvement was reported in 1985 as steroid‐responsive pneumonitis, 22 and pulmonary involvement has been the most common extracutaneous manifestation to date 23 …”

“…The first well‐documented, exclusively noninfectious explanation was proposed by Cohen 31 in 1936, who suggested that previously isolated organisms such as streptococci, staphylococci, and Pseudomonas aeruginosa , were “secondary invaders.” He instead posited the cause to be a vitamin deficiency, partially influenced by the knowledge of vitamin deficiency as a common occurrence in UC 31 . The cause of UC itself had several different considerations then, notably including infection, and the idea of a primarily infectious, bacterial aetiology for PG continued to prevail through the 1950s 20,21,32,33 …”

“…• this article synthesizes what is known about pyoderma gangrenosum into a narrative • after review, providers will have a more in depth understanding of the challenges associated with pyoderma gangrenosum when facing patients, and be aware of the current and future trends in this field independently. 20,21 The first example of PG with extracutaneous involvement was reported in 1985 as steroid-responsive pneumonitis, 22 and pulmonary involvement has been the most common extracutaneous manifestation to date. 23 Today, PG is considered an inflammatory disease which may present in association with autoimmune disorders and cancers.…”

“…31 The cause of UC itself had several different considerations then, notably including infection, and the idea of a primarily infectious, bacterial aetiology for PG continued to prevail through the 1950s. 20,21,32,33 F I G U R E 3 Landmark 1930 case series describing and naming pyoderma gangrenosum (PG) 10…”

“…18,19 Ultimately, PG has had many names, although pyoderma gangrenosum was adopted rapidly following Brunsting et al's description (Table 1). 9,21 By the 1940s, it was accepted that PG most often occurred in association with UC, but was also thought to occur with trauma, infectious arthritis, upper respiratory infection, pleuritis, pericarditis, cholecystitis, genitourinary infections, abscessed tooth, or (rarely)…”