Current Topics in Ionizing Radiation Research 2012
DOI: 10.5772/33860
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Phage-Displayed Recombinant Peptides for Non-Invasive Imaging Assessment of Tumor Responsiveness to Ionizing Radiation and Tyrosine Kinase Inhibitors

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Cited by 3 publications
(3 citation statements)
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“…Phage display technology offers potential tools for development of therapeutic agents, vaccines, diagnostic reagents, as well as gene and drug delivery systems . Determination of interaction partners of organic (proteins, polysaccharides or DNAs) or inorganic compounds and also in vitro protein engineering are the major applications of phage display technology . More recently, a number of attempts have been made for using in vitro phage display technology in medical science by designing humanized antibodies or peptides and development of new pharmaceutics for various maladies such as cancer, autoimmune and inflammatory diseases, metabolic and allergic disorders .…”
Section: Applications Of Bacteriophagesmentioning
confidence: 99%
“…Phage display technology offers potential tools for development of therapeutic agents, vaccines, diagnostic reagents, as well as gene and drug delivery systems . Determination of interaction partners of organic (proteins, polysaccharides or DNAs) or inorganic compounds and also in vitro protein engineering are the major applications of phage display technology . More recently, a number of attempts have been made for using in vitro phage display technology in medical science by designing humanized antibodies or peptides and development of new pharmaceutics for various maladies such as cancer, autoimmune and inflammatory diseases, metabolic and allergic disorders .…”
Section: Applications Of Bacteriophagesmentioning
confidence: 99%
“…The most common bacteriophages used in the "phage display" technique are M13 and filamentous phage, although T4, T7, and λ phages have also been used. 22,23 Despite the advantages of using phage in cancer studies, there are also disadvantages, for example, in vitro panning using cell lines may lead to the selection of peptides that behave differently in vivo; phages are currently difficult to prepare for use in humans and animals; most in vivo phage studies are performed on animal models; and it is complicated to determine the dose of phages being administered and the duration of the effect. 24,25 F I G U R E 1 Various applications of complete phages, capsid proteins, and phage-derived peptides in therapeutic and diagnostic approaches such as cancer vaccines development, in vitro/vivo tumor detection, and tumor-targeted delivery of therapeutic agents/imaging dyes.…”
Section: Bacteriophage and Phage Display Techniquementioning
confidence: 99%
“…Production of different phage peptide libraries using phage display was an important milestone in the introduction of phages to the arena of anticancer research 19,21 (Figure 1). The most common bacteriophages used in the “phage display” technique are M13 and filamentous phage, although T4, T7, and λ phages have also been used 22,23 . Despite the advantages of using phage in cancer studies, there are also disadvantages, for example, in vitro panning using cell lines may lead to the selection of peptides that behave differently in vivo; phages are currently difficult to prepare for use in humans and animals; most in vivo phage studies are performed on animal models; and it is complicated to determine the dose of phages being administered and the duration of the effect 24,25 …”
Section: Bacteriophage and Phage Display Techniquementioning
confidence: 99%