Phage-displayed peptides targeting specific tissues and organs

Andrieu, Josu; Russo, Laura; Nicotra, Francesco

doi:10.1080/1061186x.2018.1531419

Cited by 30 publications

(24 citation statements)

References 136 publications

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“…In contrast, small targeting moieties such as short peptides provide lower chance of immunogenicity due to lack of Fc region, increased ligand multivalency, and easy production by peptide synthesis methods [222][223][224]. Techniques such as phage display provides a means for identifying specific peptide sequences able to target selective tissues or cells [225,226]. A variety of peptides can be used either to target cell surface markers or subcellular elements in vivo.…”

Section: Targeting Peptides In Gdssmentioning

confidence: 99%

A Global Review on Short Peptides: Frontiers and Perspectives

et al. 2021

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Peptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains of life and interfere with protein-protein interactions, which are indispensable in bio-processes. Short peptides include fundamental molecular information for a prelude to the symphony of life. They have aroused considerable interest due to their unique features and great promise in innovative bio-therapies. This work focusing on the current state-of-the-art short peptide-based therapeutical developments is the first global review written by researchers from all continents, as a celebration of 100 years of peptide therapeutics since the commencement of insulin therapy in the 1920s. Peptide “drugs” initially played only the role of hormone analogs to balance disorders. Nowadays, they achieve numerous biomedical tasks, can cross membranes, or reach intracellular targets. The role of peptides in bio-processes can hardly be mimicked by other chemical substances. The article is divided into independent sections, which are related to either the progress in short peptide-based theranostics or the problems posing challenge to bio-medicine. In particular, the SWOT analysis of short peptides, their relevance in therapies of diverse diseases, improvements in (bio)synthesis platforms, advanced nano-supramolecular technologies, aptamers, altered peptide ligands and in silico methodologies to overcome peptide limitations, modern smart bio-functional materials, vaccines, and drug/gene-targeted delivery systems are discussed.

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Section: Targeting Peptides In Gdssmentioning

confidence: 99%

A Global Review on Short Peptides: Frontiers and Perspectives

et al. 2021

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“…SAM fabrication is very useful and robust, thus some recent studies have attempted to mimic collagen structures from ECM-derived binding peptides, which increased cell adhesion and cardiac repair by cardiac progenitor cells [154]. These systems can work with other self-assembling materials like phage display peptides and genetic materials to improve adhesion, proliferation, and controlled differentiation; rendering many applications in tissue engineering [155]. Wang et al reported a procedure to fabricate biomaterials for 3D scaffold formation based on SAMs from bacteriophage display [156].…”

Section: Biomaterials and 3d Scaffold Fabricationmentioning

confidence: 99%

Cardiac tissue engineering: state-of-the-art methods and outlook

et al. 2019

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The purpose of this review is to assess the state-of-the-art fabrication methods, advances in genome editing, and the use of machine learning to shape the prospective growth in cardiac tissue engineering. Those interdisciplinary emerging innovations would move forward basic research in this field and their clinical applications. The long-entrenched challenges in this field could be addressed by novel 3-dimensional (3D) scaffold substrates for cardiomyocyte (CM) growth and maturation. Stem cell-based therapy through genome editing techniques can repair gene mutation, control better maturation of CMs or even reveal its molecular clock. Finally, machine learning and precision control for improvements of the construct fabrication process and optimization in tissue-specific clonal selections with an outlook of cardiac tissue engineering are also presented.

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“…Recent studies have demonstrated only a single biopanning process is needed for simultaneously selecting affinity peptides against multiple tissues or organs (Andrieu, Re, Russo, & Nicotra, 2019;Staquicini et al, 2009). Moreover, a clinical trial of biopanning against human organs in patients has been successfully performed by Krag et al (2006).…”

Section: Selecting Targeting Peptide/protein From Phage Librarymentioning

confidence: 99%

Phage nanofibers in nanomedicine: Biopanning for early diagnosis, targeted therapy, and proteomics analysis

Cao

et al. 2020

WIREs Nanomed Nanobiotechnol

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Display of a peptide or protein of interest on the filamentous phage (also known as bacteriophage), a biological nanofiber, has opened a new route for disease diagnosis and therapy as well as proteomics. Earlier phage display was widely used in protein–protein or antigen–antibody studies. In recent years, its application in nanomedicine is becoming increasingly popular and encouraging. We aim to review the current status in this research direction. For better understanding, we start with a brief introduction of basic biology and structure of the filamentous phage. We present the principle of phage display and library construction method on the basis of the filamentous phage. We summarize the use of the phage displayed peptide library for selecting peptides with high affinity against cells or tissues. We then review the recent applications of the selected cell or tissue targeting peptides in developing new targeting probes and therapeutics to advance the early diagnosis and targeted therapy of different diseases in nanomedicine. We also discuss the integration of antibody phage display and modern proteomics in discovering new biomarkers or target proteins for disease diagnosis and therapy. Finally, we propose an outlook for further advancing the potential impact of phage display on future nanomedicine. This article is categorized under: Biology‐Inspired Nanomaterials > Protein and Virus‐Based Structures

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Phage-displayed peptides targeting specific tissues and organs

Cited by 30 publications

References 136 publications

A Global Review on Short Peptides: Frontiers and Perspectives

A Global Review on Short Peptides: Frontiers and Perspectives

Cardiac tissue engineering: state-of-the-art methods and outlook

Phage nanofibers in nanomedicine: Biopanning for early diagnosis, targeted therapy, and proteomics analysis

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