Phage Display-Based Nanotechnology Applications in Cancer Immunotherapy

Goracci, Martina; Pignochino, Ymera; Marchiò, Serena

doi:10.3390/molecules25040843

Cited by 37 publications

(27 citation statements)

References 130 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Phage-based vaccines have unique biological properties that make them ideal for the prevention and treatment of troublesome, recurrent, and chronic infections caused by various bacterial strains (including those resistant to antibiotics), viruses, fungi, and parasites and also for battling cancer (by eliciting an anti-cancer host immune response). Since phage vaccines are chemically stable, easy to store and transport, cheap to produce on a large scale, and capable of inducing a humoral and cell-mediated host immune response, they can be a valuable alternative to overcoming the limitations of conventional vaccines [ 18 , 21 , 22 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ].…”

Section: Phages As a Platform For Developing Vaccinesmentioning

confidence: 99%

Bacteriophages as Potential Tools for Use in Antimicrobial Therapy and Vaccine Development

Zalewska-Piątek

Piątek

2021

Pharmaceuticals

View full text Add to dashboard Cite

The constantly growing number of people suffering from bacterial, viral, or fungal infections, parasitic diseases, and cancers prompts the search for innovative methods of disease prevention and treatment, especially based on vaccines and targeted therapy. An additional problem is the global threat to humanity resulting from the increasing resistance of bacteria to commonly used antibiotics. Conventional vaccines based on bacteria or viruses are common and are generally effective in preventing and controlling various infectious diseases in humans. However, there are problems with the stability of these vaccines, their transport, targeted delivery, safe use, and side effects. In this context, experimental phage therapy based on viruses replicating in bacterial cells currently offers a chance for a breakthrough in the treatment of bacterial infections. Phages are not infectious and pathogenic to eukaryotic cells and do not cause diseases in human body. Furthermore, bacterial viruses are sufficient immuno-stimulators with potential adjuvant abilities, easy to transport, and store. They can also be produced on a large scale with cost reduction. In recent years, they have also provided an ideal platform for the design and production of phage-based vaccines to induce protective host immune responses. The most promising in this group are phage-displayed vaccines, allowing for the display of immunogenic peptides or proteins on the phage surfaces, or phage DNA vaccines responsible for expression of target genes (encoding protective antigens) incorporated into the phage genome. Phage vaccines inducing the production of specific antibodies may in the future protect us against infectious diseases and constitute an effective immune tool to fight cancer. Moreover, personalized phage therapy can represent the greatest medical achievement that saves lives. This review demonstrates the latest advances and developments in the use of phage vaccines to prevent human infectious diseases; phage-based therapy, including clinical trials; and personalized treatment adapted to the patient’s needs and the type of bacterial infection. It highlights the advantages and disadvantages of experimental phage therapy and, at the same time, indicates its great potential in the treatment of various diseases, especially those resistant to commonly used antibiotics. All the analyses performed look at the rich history and development of phage therapy over the past 100 years.

show abstract

Section: Phages As a Platform For Developing Vaccinesmentioning

confidence: 99%

Bacteriophages as Potential Tools for Use in Antimicrobial Therapy and Vaccine Development

Zalewska-Piątek

Piątek

2021

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

“…Table 2 describes the phage display vaccines that have been currently reported. It is worth mentioning that anticancer vaccines successfully developed in recent years have already been used in cancer immunotherapy [ 53 ]. Administration of these anticancer phage vaccines stimulate the immune system of the host to produce antibodies against cancer antigens to reduce tumor cells proliferation [ 17 ].…”

Section: Phage-based Vaccinesmentioning

confidence: 99%

Bacteriophage-Based Vaccines: A Potent Approach for Antigen Delivery

et al. 2020

View full text Add to dashboard Cite

Vaccines are considered one of the most important bioproducts in medicine. Since the development of the smallpox vaccine in 1796, several types of vaccines for many diseases have been created. However, some vaccines have shown limitations as high cost and low immune responses. In that regard, bacteriophages have been proposed as an attractive alternative for the development of more cost-effective vaccines. Phage-displayed vaccines consists in the expression of antigens on the phage surface. This approach takes advantage of inherent properties of these particles such as their adjuvant capacity, economic production and high stability, among others. To date, three types of phage-based vaccines have been developed: phage-displayed, phage DNA and hybrid phage-DNA vaccines. Typically, phage display technology has been used for the identification of new and protective epitopes, mimotopes and antigens. In this context, phage particles represent a versatile, effective and promising alternative for the development of more effective vaccine delivery systems which should be highly exploited in the future. This review describes current advances in the development of bacteriophage-based vaccines, with special attention to vaccine delivery strategies. Moreover, the immunological aspects of phage-based vaccines, as well as the applications of phage display for vaccine development, are explored. Finally, important challenges and the future of phage-bases vaccines are discussed.

show abstract

“…The possibility to probe and identify ligand–receptor interactions allowed for advancement in studies of infectious diseases [ 24 ] and cancer [ 25 , 26 ]. This resulted in improvements in drug discovery and vaccine design [ 27 ].…”

Section: Bacteriophages In Bio-related Applicationsmentioning

confidence: 99%

Application of Bacteriophages in Nanotechnology

Paczesny

Bielec

2020

Nanomaterials

View full text Add to dashboard Cite

Bacteriophages (phages for short) are viruses, which have bacteria as hosts. The single phage body virion, is a colloidal particle, often possessing a dipole moment. As such, phages were used as perfectly monodisperse systems to study various physicochemical phenomena (e.g., transport or sedimentation in complex fluids), or in the material science (e.g., as scaffolds). Nevertheless, phages also execute the life cycle to multiply and produce progeny virions. Upon completion of the life cycle of phages, the host cells are usually destroyed. Natural abilities to bind to and kill bacteria were a starting point for utilizing phages in phage therapies (i.e., medical treatments that use phages to fight bacterial infections) and for bacteria detection. Numerous applications of phages became possible thanks to phage display—a method connecting the phenotype and genotype, which allows for selecting specific peptides or proteins with affinity to a given target. Here, we review the application of bacteriophages in nanoscience, emphasizing bio-related applications, material science, soft matter research, and physical chemistry.

show abstract

Phage Display-Based Nanotechnology Applications in Cancer Immunotherapy

Cited by 37 publications

References 130 publications

Bacteriophages as Potential Tools for Use in Antimicrobial Therapy and Vaccine Development

Bacteriophages as Potential Tools for Use in Antimicrobial Therapy and Vaccine Development

Bacteriophage-Based Vaccines: A Potent Approach for Antigen Delivery

Application of Bacteriophages in Nanotechnology

Contact Info

Product

Resources

About