Phage-Based Magnetoelastic Wireless Biosensors for Detecting <i>Bacillus Anthracis</i> Spores

Wan, Jiehui; Shu, Huihua; Huang, Shichu; Fiebor, Ben; Chen, I‐Hsuan; Petrenko, Valery A.; Chin, Bryan A.

doi:10.1109/jsen.2006.890135

Cited by 59 publications

(40 citation statements)

References 24 publications

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“…Other systems based on the same principle have been developed before for detecting other biological agents (Lakshmanan et al, 2007;Wan et al, 2007) The system consists of the following elements ( Fig.1):…”

Section: In Situ Measurement Of the Mass Evolution Of Cell Culturementioning

confidence: 99%

Magnetic Sensors for Biomedical Applications

Rivero¹,

Multigner²,

Spottorno³

2012

Magnetic Sensors - Principles and Applications

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Section: In Situ Measurement Of the Mass Evolution Of Cell Culturementioning

confidence: 99%

Magnetic Sensors for Biomedical Applications

Rivero¹,

Multigner²,

Spottorno³

2012

Magnetic Sensors - Principles and Applications

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“…Alfadhel, 1,a) Y. Gianchandani, 2 This paper reports the development of integrated micro-sensors consisting of 1 -lm-thick magnetostrictive cantilevers or bridges with 500 lm in length and conducting interrogation elements. The thin films are fabricated by sputter deposition of NiFe doped with B and Mo, and the magnetic properties are enhanced by field annealing, resulting in a coercivity of 2.4 Oe.…”

Section: Microfabrication Of Magnetostrictive Beams Based On Nife Filmentioning

confidence: 99%

“…Binding of the target causes a change in the resonant frequency, which, in turn, enables analyte detection and quantification. 2 Recently, devices that utilize magnetostrictive materials for sensing have been investigated. Compared to other options, such as silicon cantilevers, these vibrate in longitudinal direction instead of transverse direction, leading to higher resonant frequencies.…”

Section: Microfabrication Of Magnetostrictive Beams Based On Nife Filmentioning

confidence: 99%

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Microfabrication of magnetostrictive beams based on NiFe film doped with B and Mo for integrated sensor systems

Alfadhel

Gianchandani

Kosel

2012

Journal of Applied Physics

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This paper reports the development of integrated micro-sensors consisting of 1 -µm-thick magnetostrictive cantilevers or bridges with 500 µm in length and conducting interrogation elements. The thin films are fabricated by sputter deposition of NiFe doped with B and Mo, and the magnetic properties are enhanced by field annealing, resulting in a coercivity of 2.4 Oe. In operation, an alternating current applied to the interrogation elements magnetizes the magnetostrictive structures. The longitudinal resonant frequency is detected as an impedance change of the interrogation elements. The magnetostrictive micro-beams provide high resonant frequencies—2.95 MHz for the cantilever and 5.46 MHz for the bridge—which can be exploited to develop sensors of high sensitivity.

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“…Recently, the use of magnetoelastic biosensors for remote monitoring of food borne pathogens [1,2] and other sensing applications such as detection of Bacillus anthracis spores [3], calcium oxalate and brushite [4], ricin [5], urea [6], and endotoxin [7] have attracted considerable interest. Magnetoelastic materials are amorphous ferromagnetic alloys that are comprised of iron, nickel, molybdenum and boron.…”

Section: Introductionmentioning

confidence: 99%

Analytical performance and characterization of antibody immobilized magnetoelastic biosensors

Guntupalli

Lakshmanan

Wan

et al. 2007

Sens. & Instrumen. Food Qual.

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This article presents the results of an investigation into the enhancement of sensitivity and thermal stability of polyclonal antibody immobilized magnetoelastic biosensors. The Langmuir-Blodgett (LB) monolayer technique was employed for antibody (specific to Salmonella sp.) immobilization on rectangular shaped strip magnetoelastic sensors. Biosensor performance was investigated by exposing to graded concentrations (5 9 10 1 -5 9 10 8 cfu mL -1 ) of Salmonella typhimurium solutions in a flow through mode. Bacterial binding to the antibody on the sensor surfaces changed the resonance parameters, and these changes were quantified by the sensor's resonance frequency shift. An increase in the sensitivity from 159 Hz decade -1 for a 2 mm sensor to 246 Hz decade -1 for a 1 mm sensor was observed during the dose-response measurements. The stability of the biosensor was also investigated by storing the biosensor at 25, 45 and 65°C. The binding activity of the stored biosensor was estimated by measuring the changes in resonance frequency after exposure to the bacterial solutions (10 9 cfu mL -1 ). Binding activity was also confirmed by counting bound S. typhimurium cells on the sensor surface using Scanning Electron Microscopy (SEM) micrographs. The results show that at each temperature, the binding activity of the biosensor gradually decreased over the testing period. Degradation of biosensor accelerated at higher storage temperatures. The activation energy of biosensor system degradation was determined to be 7.7 kcal mol -1 .

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Phage-Based Magnetoelastic Wireless Biosensors for Detecting Bacillus Anthracis Spores

Cited by 59 publications

References 24 publications

Magnetic Sensors for Biomedical Applications

Magnetic Sensors for Biomedical Applications

Microfabrication of magnetostrictive beams based on NiFe film doped with B and Mo for integrated sensor systems

Analytical performance and characterization of antibody immobilized magnetoelastic biosensors

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