pH triggered injectable amphiphilic hydrogel containing doxorubicin and paclitaxel

Zhao, Lingling; Zhu, Lijun; Liu, Fuyong; Liu, Chenyang; Shan-Dan,; Wang, Qian; Zhang, Chengliang; Li, Jiaoli; Liu, Jiguang; Qu, Xiaozhong; Yang, Zhenzhong

doi:10.1016/j.ijpharm.2011.03.034

Cited by 151 publications

(82 citation statements)

References 45 publications

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“…The signifi cant challenge for micellar drug delivery is to control the release behavior of drugs in a desired manner, which motivates to construct "smart" micelles from responsive polymers and polymer mixtures. [ 10,11 ] Various internal and external stimuli, such as temperature, [ 12,13 ] pH, [14][15][16][17] redox, [18][19][20][21] light, [ 22,23 ] and ultrasound [24][25][26][27] have been applied to modulate drug release behaviors.…”

mentioning

confidence: 99%

Polypeptide‐Based “Smart” Micelles for Dual‐Drug Delivery: A Combination Study of Experiments and Simulations

Chen

Jiang

Cai

et al. 2014

Adv Healthcare Materials

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A dual-drug-loaded micelle is designed and constructed from a mixture of poly(propylene oxide)-b-poly(γ-benzyl-l-glutamate)-b-poly(ethylene glycol) (PPO-b-PBLG-b-PEG) triblock terpolymers and two model drugs, doxorubicin (DOX) and naproxen (Nap). In the micelles, the DOX is chemically linked to the PBLG backbones through an acid-cleavable hydrazone bond, whereas the Nap is physically encapsulated in the cores. The drug loading and releasing behaviors of the dual-drug-loaded micelles as well as single drug-loaded micelles (DOX-conjugated or Nap-loaded micelles) are studied. The structures of micelles are characterized by means of microscopies and dynamic light scattering, and further examined by dissipative particle dynamics (DPD) simulations. It is revealed that the micelles possess a core-shell-corona structure in which the PPO/Nap, PBLG/DOX, and PEG aggregate to form the core, shell, and corona, respectively. In vitro studies reveal that the release of DOX and Nap is pH- and thermosensitive. Such drug releasing behaviors are also examined by DPD simulations, and more information regarding the mechanism is obtained. In addition, the bio-related properties such as cellular uptake of the micelles and biocompatibility of the deliveries are evaluated. The results show that the dual-drug-loaded micelles are biocompatible at normal physiological conditions and retain the anti-cancer efficiency.

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confidence: 99%

Polypeptide‐Based “Smart” Micelles for Dual‐Drug Delivery: A Combination Study of Experiments and Simulations

Chen

Jiang

Cai

et al. 2014

Adv Healthcare Materials

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“…9 In addition to an enhanced healing effect, the drug entrapment efficiency of chitin/chitosan allows a wide range of topically pharmaceutical applications to microencapsulate drugs such as hydrogels, films and microspheres. [10][11][12][13][14][15] Various modifications of chitin and chitosan have been investigated for their practical applicability and in light of the intractable bulk structure of chitin. [16][17][18] Water-soluble chitin (WSC), which is 50% randomly deacetylated, is known to be soluble in water at room temperature.…”

Section: Introductionmentioning

confidence: 99%

Development of an Amphiphilic Chitin Derivative with Lipid/Peptide-Type Side Chains Having Skin Protective Ability

Aoi¹

2015

JNHFE

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“…The physical properties, including swelling, permeation, mechanical strength, and surface characteristics, can be modulated through structural modification. Hydrogels based on natural polymers are currently receiving a great deal of interest, and are notable for controlled delivery of bioactive molecules and tissue engineering [1][2][3][4] .…”

Section: Introductionmentioning

confidence: 99%

Modified chitosan hydrogels as drug delivery and tissue engineering systems: present status and applications

Giri¹,

Thakur²,

Alexander³

et al. 2012

Acta Pharmaceutica Sinica B

295

137

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Chitosan, a natural cationic polysaccharide, is prepared industrially by the hydrolysis of the aminoacetyl groups of chitin, a naturally available marine polymer. Chitosan is a non-toxic, biocompatible and biodegradable polymer and has attracted considerable interest in a wide range of biomedical and pharmaceutical applications including drug delivery, cosmetics, and tissue engineering. The primary hydroxyl and amine groups located on the backbone of chitosan are responsible for the reactivity of the polymer and also act as sites for chemical modification. However, chitosan has certain limitations for use in controlled drug delivery and tissue engineering. These limitations can be overcome by chemical modification. Thus, modified chitosan hydrogels have gained importance in current research on drug delivery and tissue engineering systems. This paper reviews the general properties of chitosan, various methods of modification, and applications of modified chitosan hydrogels.

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pH triggered injectable amphiphilic hydrogel containing doxorubicin and paclitaxel

Cited by 151 publications

References 45 publications

Polypeptide‐Based “Smart” Micelles for Dual‐Drug Delivery: A Combination Study of Experiments and Simulations

Polypeptide‐Based “Smart” Micelles for Dual‐Drug Delivery: A Combination Study of Experiments and Simulations

Development of an Amphiphilic Chitin Derivative with Lipid/Peptide-Type Side Chains Having Skin Protective Ability

Modified chitosan hydrogels as drug delivery and tissue engineering systems: present status and applications

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