pH-triggered degradation and release of doxorubicin from zeolitic imidazolate framework-8 (ZIF8) decorated with polyacrylic acid

Tran, Vy Anh; Lee, Sang−Wha

doi:10.1039/d0ra10423j

Cited by 56 publications

(33 citation statements)

References 75 publications

(95 reference statements)

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“…The Dox-loaded ZIF8 was modified with PAA (ZIF8–Dox@PAA) ( Figure 9 ). Finally, they have studied the release manner of Dox at different pH and the influence of various factors on its release [ 121 ].…”

Section: Bio-conjugation With Other Materialsmentioning

confidence: 99%

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

et al. 2022

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Polyacrylic acid (PAA) is a non-toxic, biocompatible, and biodegradable polymer that gained lots of interest in recent years. PAA nano-derivatives can be obtained by chemical modification of carboxyl groups with superior chemical properties in comparison to unmodified PAA. For example, nano-particles produced from PAA derivatives can be used to deliver drugs due to their stability and biocompatibility. PAA and its nanoconjugates could also be regarded as stimuli-responsive platforms that make them ideal for drug delivery and antimicrobial applications. These properties make PAA a good candidate for conventional and novel drug carrier systems. Here, we started with synthesis approaches, structure characteristics, and other architectures of PAA nanoplatforms. Then, different conjugations of PAA/nanostructures and their potential in various fields of nanomedicine such as antimicrobial, anticancer, imaging, biosensor, and tissue engineering were discussed. Finally, biocompatibility and challenges of PAA nanoplatforms were highlighted. This review will provide fundamental knowledge and current information connected to the PAA nanoplatforms and their applications in biological fields for a broad audience of researchers, engineers, and newcomers. In this light, PAA nanoplatforms could have great potential for the research and development of new nano vaccines and nano drugs in the future.

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Section: Bio-conjugation With Other Materialsmentioning

confidence: 99%

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

et al. 2022

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“…Among current materials such as silica [8,9], metal organic frameworks [10][11][12][13][14][15], composites [16][17][18][19], and metal compounds [20][21][22], mesoporous silicon NPs have received considerable attention in the field of biomedical drug delivery due to their outstanding properties such as in vitro biocompatibility, in vivo biodegradability, and high photothermal activity [23,24]. A complete magnesiothermic reduction of mesoporous silica NPs (MSN) has provided a platform for the rational design of multifunctional silicon nanostructures for controlled and targeted delivery of therapeutic agents [25,26].…”

Section: Introductionmentioning

confidence: 99%

Dual Stimuli-Responsive Multifunctional Silicon Nanocarriers for Specifically Targeting Mitochondria in Human Cancer Cells

et al. 2022

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Specific targeting, selective stimuli-responsiveness, and controlled release of anticancer agents are requested for high therapeutic efficiency with a minimal adverse effect. Herein, we report the sophisticated synthesis and functionalization of fluorescent mesoporous silicon (FMPSi) nanoparticles decorated with graphene oxide (GO) nanosheets. GO-wrapped FMPSi (FMPSi@GO) was loaded with a cisplatin (Cis) anticancer agent, and Cis-loaded FMPSi@GO (FMPSi-Cis@GO) exhibited the dual stimuli (pH and NIR)-responsiveness of controlled drug release, i.e., the drug release rate was distinctly enhanced at acidic pH 5.5 than at neutral pH 7.0 and further enhanced under NIR irradiation at acidic pH condition. Notably, dequalinium-conjugated FMPSi-Cis@GO (FMPSi-Cis@GO@DQA) demonstrated an excellent specificity for mitochondrial targeting in cancer cells without noticeable toxicity to normal human cells. Our novel silicon nanocarriers demonstrated not only stimuli (pH and NIR)-responsive controlled drug release, but also selective accumulation in the mitochondria of cancer cells and destroying them.

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“…ZIF8 is a crystalline, highly porous material that consists of zinc-coordinated 2methylimidazole molecules with pH-sensitive linker−metal bonds. 30 The micropores of ZIF8 nanoparticles are encapsulated with either ultrasmall gold nanoparticles or anticancer drug curcumin to ameliorate the performance of the hydrogel at an equivalent weight ratio. The broad NIR absorbance by the Au@ZIF8 nanoparticles due to plasmon coupling between the encapsulated gold nanoparticles is explored for localized photothermal therapy (PTT), in addition to intratumoral delivery of anticancer curcumin.…”

Section: Introductionmentioning

confidence: 99%

Plasmonically Active Supramolecular Polymer–Metal–Organic Framework Hydrogel Nanocomposite for Localized Chemo-photothermal Therapy

Kaur¹,

Mimansa²,

Kumar³

et al. 2022

ACS Appl. Polym. Mater.

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Hydrogels are a three-dimensional cross-linked network of hydrophilic polymers, extensively used for biomedical, biotechnological, and pharmaceutical applications. The functionality of hydrogels could be enhanced by synthesizing hydrogel nanocomposites that can both enable controlled release of drugs in a cancerous microenvironment and near-infrared-induced localized heat generation for combined chemo-photothermal therapy (chemo-PTT), a potent anticancer therapeutic approach. Herein, we developed a plasmonically active hydrogel with carboxymethyl chitosan (CMC) as the supporting matrix cross-linked with ZIF8 nanoparticles and Mg 2+ . The ZIF8 nanoparticles were loaded in situ with ultrasmall gold nanoparticles (UsGNPs) and an anticancer drug curcumin for localized chemo-PTT. The plasmonic hydrogel (PHG) showed viscoelastic and self-healing properties governed by the supramolecular interaction between ZIF8 and CMC. The injectable PHG exhibited a photothermal conversion efficiency of ∼41%. Chemo-PTT with Cur-PHG effectively inhibited 4T1 breast cancer under both in vitro and in vivo conditions. The biocompatible PHG was found to release UsGNPs from tumor tissues post intratumoral injection followed by predominant distribution in the liver and kidney. Due to the size of UsGNPs (<5 nm), they were consistently detected in urine over the period of treatment confirming the overall degradable nature of PHG that delivers a localized outcome with negligible systemic toxicity.

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pH-triggered degradation and release of doxorubicin from zeolitic imidazolate framework-8 (ZIF8) decorated with polyacrylic acid

Abstract: The ZIF8–Dox@PAA nanocarrier demonstrated pH-triggered drug release through the detachment of the PAA layer along with the destruction of ZIF8 framework in acidic pH environment.

Cited by 56 publications

References 75 publications

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

Dual Stimuli-Responsive Multifunctional Silicon Nanocarriers for Specifically Targeting Mitochondria in Human Cancer Cells

Plasmonically Active Supramolecular Polymer–Metal–Organic Framework Hydrogel Nanocomposite for Localized Chemo-photothermal Therapy

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