pH sensitive N-succinyl chitosan grafted polyacrylamide hydrogel for oral insulin delivery

Mukhopadhyay, Piyasi; Sarkar, Kishor; Bhattacharya, Sourav; Bhattacharyya, Amitava; Mishra, Roshnara; Kundu, Patit Paban

doi:10.1016/j.carbpol.2014.06.045

Cited by 181 publications

(99 citation statements)

References 27 publications

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“…But, for succinated chitosan, the peak at 10 disappears and the reflection at 20 also significantly decreases [53]. This may occur due to the destruction of intermolecular hydrogen bonds between amine groups and hydroxyl groups of the native chitosan [54]. The Cs-g-PBA graft copolymer displayed a much weaker diffraction at 2q ¼ 21.44 and 24.4 which represent the (110) and (020) reflections, respectively.…”

Section: Determination Of Shell-crosslinked Structurementioning

confidence: 99%

Design, characterization and in vitro evaluation of novel shell crosslinked poly(butylene adipate)-co-N-succinyl chitosan nanogels containing loteprednol etabonate: A new system for therapeutic effect enhancement via controlled drug delivery

Nasr

Khoee

2015

European Journal of Medicinal Chemistry

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Section: Determination Of Shell-crosslinked Structurementioning

confidence: 99%

Design, characterization and in vitro evaluation of novel shell crosslinked poly(butylene adipate)-co-N-succinyl chitosan nanogels containing loteprednol etabonate: A new system for therapeutic effect enhancement via controlled drug delivery

Nasr

Khoee

2015

European Journal of Medicinal Chemistry

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“…These results could also be explained due to the highly porous nature of the lyomatrix, while the tablets possessed a more compact structure as confirmed by SEM. Thus porosity had a pertinent role in the hydration, swelling, and erosion of the lyomatrix to affect controlled drug release (5,7,8).…”

Section: Analysis Of the Physicomechanical Behavior Of The Lyomatrixmentioning

confidence: 99%

“…This necessitates frequent administration of GCV. Recently, increased attention has been provided to polymers that are able to alter their volume and properties in response to pH stimulation for application in the design of specialized gastroprotective oral drug delivery systems (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Intestinal Targeting of Ganciclovir Release Employing a Novel HEC-PAA Blended Lyomatrix

et al. 2015

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Abstract. A hydroxyethylcellulose-poly(acrylic acid) (HEC-PAA) lyomatrix was developed for ganciclovir (GCV) intestine targeting to overcome its undesirable degradation in the stomach. GCV was encapsulated within the HEC-PAA lyomatrix prepared by lyophilization. Conventional tablets were also prepared with identical GCV concentrations in order to compare the GCV release behavior from the lyomatrix and tablets. GCV incorporation (75.12%) was confirmed using FTIR, DSC, and TGA. The effect of GCV loading on the microstructure properties of the lyomatrix was evaluated by SEM, AFM, and BET surface area measurements. The in vitro drug release study showed steady and rapid release profiles from the GCV-loaded lyomatrix compared with the tablet formulation at identical pH values. Minimum GCV release was observed at acidic pH (≤40%) and maximum release occurred at intestinal pH values (≥90%) proving the intestinal targeting ability of the lyomatrix. Kinetic modeling revealed that the GCV-loaded lyomatrix exhibited zero-order release kinetics (n=1), while the tablets were best described via the Peppas model. Textural analysis highlighted enhanced matrix resilience and rigidity gradient (12.5%, 20 Pa) for the GCV-loaded lyomatrix compared to the pure (7%, 9.5 Pa) HEC-PAA lyomatrix. Bench-top MRI imaging was used to confirm the mechanism of GCV release behavior by monitoring the swelling and erosion rates. The swelling and erosion rate of the tablets was not sufficient to achieve rapid zero-order GCV release as with the lyomatrix. These combined results suggest that the HEC-PAA lyomatrix may be suitable for GCV intestinal targeting after oral administration.

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“…In addition, the peaks at 1,649 and 1,560 cm −1 were identified as deformation vibrations of primary amine and secondary amine in chitosan. 33 These characteristic peaks were also observed in the IR spectra of PLGA-chitosan.…”

Section: Resultsmentioning

confidence: 71%

Controlled-release of tetracycline and lovastatin by poly(D,L-lactide-co-glycolide acid)-chitosan nanoparticles enhances periodontal regeneration in dogs

Lee

Wang

et al. 2016

IJN

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Chronic periodontitis is characterized by inflammation of periodontal tissues, leading to bone resorption and tooth loss. The goal of treatment is to regenerate periodontal tissues including bone and cementum lost as a consequence of disease. The local delivery of tetracycline was proven to be effective in controlling localized periodontal infection without apparent side effects. Previous studies suggested that lovastatin has a significant role in new bone formation; however, the local delivery of lovastatin might enhance its therapeutic effects. A number of local delivery devices have been developed recently, including poly( d , l -lactide-co-glycolide acid) (PLGA) nanoparticles. The aim of this study was to develop a local delivery device, PLGA-lovastatin-chitosan-tetracycline nanoparticles, which allows the sequential release of tetracycline and lovastatin to effectively control local infection and promote bone regeneration in periodontitis. The size and microstructure of nanoparticles were examined by transmission electron microscopy, Nanoparticle Size Analyzer, and Fourier transform infrared spectroscopy. The release of tetracycline and lovastatin was quantified using a UV-Vis spectrophotometer. Furthermore, the cytotoxic effect and alkaline phosphatase activity of the nanoparticles in osteoblast cell cultures as well as antibacterial activity against periodontal pathogens were investigated. Finally, the bone regeneration potential of PLGA nanoparticles in three-walled defects in beagle dogs was investigated. The results indicated that PLGA-lovastatin-chitosan-tetracycline nanoparticles showed good biocompatibility, antibacterial activity, and increased alkaline phosphatase activity. The volumetric analysis from micro-CT revealed significantly increased new bone formation in defects filled with nanoparticles in dogs. This novel local delivery device might be useful as an adjunctive treatment in periodontal regenerative therapy.

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pH sensitive N-succinyl chitosan grafted polyacrylamide hydrogel for oral insulin delivery

Cited by 181 publications

References 27 publications

Design, characterization and in vitro evaluation of novel shell crosslinked poly(butylene adipate)-co-N-succinyl chitosan nanogels containing loteprednol etabonate: A new system for therapeutic effect enhancement via controlled drug delivery

Design, characterization and in vitro evaluation of novel shell crosslinked poly(butylene adipate)-co-N-succinyl chitosan nanogels containing loteprednol etabonate: A new system for therapeutic effect enhancement via controlled drug delivery

Intestinal Targeting of Ganciclovir Release Employing a Novel HEC-PAA Blended Lyomatrix

Controlled-release of tetracycline and lovastatin by poly(D,L-lactide-co-glycolide acid)-chitosan nanoparticles enhances periodontal regeneration in dogs

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