Controlled-release of tetracycline and lovastatin by poly(D,L-lactide-co-glycolide acid)-chitosan nanoparticles enhances periodontal regeneration in dogs

Lee, Bor-Shiunn; Lee, Chien-Chen; Wang, Yi Ping; Chen, Hsiao-Jan; Lai, Chung-Sheng; Hsieh, Wan-Ling; Chen, Yi‐Wen

doi:10.2147/ijn.s94270

Cited by 38 publications

(12 citation statements)

References 44 publications

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“…The biomaterial scaffold as the cell carrier and exogenous graft should have a positive effect or no palpable side effect on cell growth and differentiation, and it should be accompanied by good biocompatibility and easy degradation in vivo after implantation [ 11 , 12 ]. PLGA has been served as a drug carrier because of its biocompatibility and biodegradation [ 13 , 14 ]. Seed cells derived from autologous tissue used to construct engineered tissue are the preferable choice.…”

Section: Discussionmentioning

confidence: 99%

Combining PLGA Scaffold and MSCs for Brain Tissue Engineering: A Potential Tool for Treatment of Brain Injury

Zhou

Fang

et al. 2018

Stem Cells International

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Nerve tissue engineering is an important strategy for the treatment of brain injuries. Mesenchymal stem cell (MSC) transplantation has been proven to be able to promote repair and functional recovery of brain damage, and poly (lactic-co-glycolic acid) (PLGA) has also been found to have the capability of bearing cells. In the present study, to observe the ability of PLGA scaffold in supporting the adherent growth of MSCs and neurons in vivo and vitro and to assess the effects of PLGA scaffold on proliferation and neural differentiation of MSCs, this study undertakes the following steps. First, MSCs and neurons were cultured and labeled with green fluorescent protein (GFP) or otherwise identified and the PLGA scaffold was synthesized. Next, MSCs and neurons were inoculated on PLGA scaffolds and their adhesion rates were investigated and the proliferation of MSCs was evaluated by using MTT assay. After MSCs were induced by a neural induction medium, the morphological change and neural differentiation of MSCs were detected using scanning electron microscopy (SEM) and immunocytochemistry, respectively. Finally, cell migration and adhesion in the PLGA scaffold in vivo were examined by immunohistochemistry, nuclear staining, and SEM. The experimental results demonstrated that PLGA did not interfere with the proliferation and neural differentiation of MSCs and that MSCs and neuron could grow and migrate in PLGA scaffold. These data suggest that the MSC-PLGA complex may be used as tissue engineering material for brain injuries.

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Section: Discussionmentioning

confidence: 99%

Combining PLGA Scaffold and MSCs for Brain Tissue Engineering: A Potential Tool for Treatment of Brain Injury

Zhou

Fang

et al. 2018

Stem Cells International

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“…The resulting nanofibres have the potential to be incorporated into PMMA based resin to produce denture materials. Another biopolymer chitosan, has also been reported as a nanocarrier for antibacterial compounds for application in dental diseases (B. S. Lee et al, 2016).…”

Section: Polymeric Nanomaterialsmentioning

confidence: 99%

Strategies toward development of antimicrobial biomaterials for dental healthcare applications

Parhi

Pal

Das

et al. 2021

Biotech & Bioengineering

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Several approaches for elimination of oral pathogens are being explored at the present time since oral diseases remain prevalent affecting approximately 3.5 billion people worldwide. Need for antimicrobial biomaterials in dental healthcare include but is not restricted to designing resin composites and adhesives for prevention of dental caries. Constant efforts are also being made to develop antimicrobial strategies for clearance of endodontic space prior root canal treatment and for treatment of periimplantitis and periodontitis. This article discusses various conventional | © 2021 Wiley Periodicals LLC Microorganisms Type of disease References Lactobacilli Dental caries Caufield et al. (2015) (Mutans streptococci) Streptococcus mutans, Streptococcus sorbinus Dianawati et al. (2020) Aggregatibacter actinomycetemcomitans Periodontitis Oscarsson et al. (2019) Porphyromonas gingivalis Z. He et al. (2020) Fusobacterium nucleatum Endodontic infection Martinho et al. (2016); Matsui et al. (2014) Enterococcus faecalis Alghamdi and Shakir (2020)

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“…Despite pioneering studies, the possibility of using MPDA nanoparticles loaded with tetracycline hydrochloride (TH) and wrapped with GO as a drug carrier has not yet been demonstrated to the best of our knowledge. TH is used as the model drug in this work because it is a well-known broad-spectrum antibiotic with low toxicity and its local delivery is known to be effective in the control of bacterial infections …”

Section: Introductionmentioning

confidence: 99%

“…TH is used as the model drug in this work because it is a well-known broad-spectrum antibiotic with low toxicity and its local delivery is known to be effective in the control of bacterial infections. 16 GO, the two-dimensional layer of sp 2 -bonded carbon, with rich functional groups on its surface, including epoxy, hydroxyl, and carboxyl groups, has received tremendous attention in the field of materials. 17,18 In 2008, Dai et al first reported that GO can be used as an efficient nanocarrier for drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Construction of a Mesoporous Polydopamine@GO/Cellulose Nanofibril Composite Hydrogel with an Encapsulation Structure for Controllable Drug Release and Toxicity Shielding

Liu

Fan

Huo

et al. 2020

ACS Appl. Mater. Interfaces

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The development of intelligent and multifunctional hydrogels having photothermal properties, good mechanical properties, sustained drug release abilities with low burst release, antibacterial properties, and biocompatibility is highly desirable in the biomaterial field. Herein, mesoporous polydopamine (MPDA) nanoparticles wrapped with graphene oxide (GO) were physically cross-linked in cellulose nanofibril (CNF) hydrogel to obtain a novel MPDA@GO/CNF composite hydrogel for controllable drug release. MPDA nanoparticles exhibited a high drug loading ratio (up to 35 wt %) for tetracycline hydrochloride (TH). GO was used to encapsulate MPDA nanoparticles for extending the drug release time and reinforcing the physical strength of the obtained hydrogel. The mechanical strength of the as-fabricated MPDA@GO/CNF composite hydrogel was five times greater compared to that of the pure CNF hydrogel. Drug release experiments demonstrated that burst release behavior was significantly reduced by adding MPDA@GO. The drug release time of the MPDA@GO/CNF composite hydrogel was 3 times and 7.2 times longer than that of the polydopamine/CNF hydrogel and pure CNF hydrogel, respectively. The sustained and controlled drug release behaviors of the composite hydrogel were highly dependent on the proportion of MPDA and GO. Moreover, the rate of drug release could be accelerated by near-infrared (NIR) light irradiation and pH value change. The drug release kinetics of the as-prepared composite hydrogel was well described by the Korsmeyer−Peppas model, and the drug release mechanism of TH from the composite hydrogel was anomalous transport. Importantly, this carefully designed MPDA@GO/CNF composite hydrogel showed good biocompatibility through an in vitro cytotoxicity test. In particular, the toxicity of GO was well shielded by the CNF hydrogel. Therefore, this novel MPDA@GO/CNF composite hydrogel with an encapsulation structure for controllable drug release and toxicity shielding of GO could be used as a very promising controlled drug delivery carrier, which may have potential applications for chemical and physical therapies.

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Controlled-release of tetracycline and lovastatin by poly(D,L-lactide-co-glycolide acid)-chitosan nanoparticles enhances periodontal regeneration in dogs

Cited by 38 publications

References 44 publications

Combining PLGA Scaffold and MSCs for Brain Tissue Engineering: A Potential Tool for Treatment of Brain Injury

Combining PLGA Scaffold and MSCs for Brain Tissue Engineering: A Potential Tool for Treatment of Brain Injury

Strategies toward development of antimicrobial biomaterials for dental healthcare applications

Construction of a Mesoporous Polydopamine@GO/Cellulose Nanofibril Composite Hydrogel with an Encapsulation Structure for Controllable Drug Release and Toxicity Shielding

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