pH-sensitive interpenetrating network hydrogels based on pachyman and its carboxymethylated derivatives for oral drug delivery

Abstract

pH-sensitive, interpenetrating polymer network hydrogels were synthesized based on pachyman and its carboxymethylated derivatives (CMP) by the confunctional crosslinker agent epichlorohydrin. The structure and morphology of pachyman/CMP (CPCS) hydrogels were characterized. In the swelling assays, the composite hydrogels maintained remarkable swelling capacity and significant good pH sensitivity. The swelling behavior was much improved by the incorporation of CMP than the pure pachyman hydrogels. While increasing the content of CMP in the hydrogels, the equilibrium swelling time was more reduced and the swelling ratio increased obviously due to the better water solubility of CMP. In the drug release study, the results indicated that CPCS hydrogels demonstrate better pH-resistant sustained drug release for bovine serum albumin, and the adjustment of the proportion of pachyman to CMP results in improved drug release behavior, which suggests that the CPCS hydrogels are promising candidates for sustained drug delivery system.

Carboxymethylpachymaran-Coated Zein Nanoparticles for Oral Delivery of Curcumin: Formation, Characterization, Physicochemical Stability, and Controlled Release Properties

“…Meanwhile, as shown in Figure C, the spherical ZMNPs with different sizes connected with each other to form a network structure. Because the CMP is rich in hydroxyl and charged groups, it is easy to form ordered structures such as multi-helix and network. , In Figure D, the microstructure of ZMCNPs is similar to that of ZNPs, and their shape distribution is relatively uniform compared with ZMNPs, which may be caused by the interaction between Cur, zein, and CMP. In addition, the particle size of its nanoparticles is smaller than that of DLS data, which may be due to partial aggregation during the formation of nanoparticles.…”

Design and optimization of thermosensitive injectable alginate-based hydrogels: potential for loading therapeutic compounds

“…The LCST causes the polymers to be injected into the body in a liquid state that is followed by gelation at physiological temperature to create a cross-linked hydrogel (45,46). However, hydrogels based on natural polymers have some limitations including explosive release of drug and the unavoidable leakage phenomenon due to the extremely hydrophilic properties and low mechanical strength of the hydrogel network (47,48). To control these obstacles, HPMC was used together with SA to prepare the hydrogels in this study.…”

Preparation, Characterization, and Release Behavior of Doxorubicin hydrochloride from Dual Cross-Linked Chitosan/Alginate Hydrogel Beads

“…The dried CS/SALG hydrogel beads (0.5 g) were immersed in 30 mL of swelling media (SGF, SIF, or SCF). At specific intervals (checkpoints), the hydrogel beads were removed, their surface moisture was absorbed with tissue paper, and then weighed before reimmersing into the swelling media, − until the weights of the swollen microbeads were constant. All of the experimental procedures were carried out at 37.2 °C.…”